On the use of the push-pull cannula as a means of measuring biochemical changes during ongoing behavior

Tilson, Hugh A.; Sparber, Sheldon B.

doi:10.3758/bf03211022

Cited by 15 publications

(2 citation statements)

References 12 publications

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“…Push-pull perfusion of brain has been useful in showing effects of psychotropic drugs on release or efflux of transmitters in vivo (Gaddurn, 1961; McKenzie and Szerb, 1968; Portig and Vogt, 1969;Tilson and Sparber, 1970). The availability of newer analytical methods has made it possible to analyze easily small quantities of endogenous morioamines and their metabolites in brain perfusion samples (Van Der Gugten and Slangen, 1977;Loullis et id., 1980;Philips et al, 1982).…”

mentioning

confidence: 99%

Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Kleven

Dwoskin

Sparber

1983

Journal of Neurochemistry

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The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5-hydroxyindoleacetic acid (5-HIAA) in brain perfusate of rats implanted with push-pull cannulas. This occurred in conjunction with its suppressant effect upon fixed-ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5-HIAA only after 5-HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5-hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.

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mentioning

confidence: 99%

Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Kleven

Dwoskin

Sparber

1983

Journal of Neurochemistry

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“…The use of push-pull perfusion techniques to measure neurochemical changes correlated with ongoing behavior was pioneered by Sparber and his colleagues in the early 1970s [Tilson and Sparber, 1970;review by Sparber, 19751. This was approximately the same time that Seiden's laboratory was initiating the study of neurochemical correlates of behavior using techniques to study metabolism.…”

Section: Push-pull Perfusion Studiesmentioning

confidence: 99%

Neurochemical correlates of behavioral processes

Barrett

Nader

1990

Drug Development Research

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Cumulative developments in the experimental analysis of behavior and behavioral pharmacology, together with relatively recent technical advances in the field of neuroscience, have provided a strong impetus to build on previous research and combine these disciplines into an integrated approach focusing on behavioral neurochemistry. Neither behavioral nor neurochemical changes are static independent processes but interact in dynamic and complex ways. Neurotransmitter activity can be conditioned using both classical Pavlovian and operant conditioning procedures. Neurochemical changes also occur when behavior is brought under the control of its environmental consequences. Behavioral variables such as the schedule-controlled rate of responding, prior history, and environmental context have been shown repeatedly to determine the effects of drugs and appear to have definable and distinctive neurochemical correlates. These variables may modify neurochemical substrates involved in drug action. Ongoing changes in behavior and neurochemistry are now concurrently accessible for experimental analysis. The synthesis of these two fields permits the exploration of behavioral and neurochemical interactions that were not easily accessible only a short time ago and promises to yield considerable information about both behavioral and neurochemical processes. This article summarizes the development of research in behavioral neurochemistry and attempts to show how a continuation of these endeavors can provide a better understanding of the interrelationships between behavior and neurochemistry as determinants of drug action.

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Neurochemical changes associated with schedule-controlled behavior

Sparber

1975

Behavioral Pharmacology

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On the use of the push-pull cannula as a means of measuring biochemical changes during ongoing behavior

Cited by 15 publications

References 12 publications

Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Neurochemical correlates of behavioral processes

Neurochemical changes associated with schedule-controlled behavior

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