2018
DOI: 10.1016/j.actbio.2018.04.040
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On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

Abstract: The ability of iron-doped hydroxyapatite nanoaprticles (FeHA) to work in vivo as imaging agents for magnetic resonance (MR) and nuclear imaging is demonstrated. FeHA applied an higher MR contrast in the liver, spleen and kidneys of mice with respect to Endorem®. The successful radiolabeling of FeHA allowed for scintigraphy/X-ray and ex vivo biodistribution studies, confirming MR results and envisioning FeHA application for dual-imaging.

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Cited by 55 publications
(39 citation statements)
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References 61 publications
(82 reference statements)
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“…FeHAs have essentially been characterized in a previous work [ 16 ]. According to the earlier reported magnetic characterizations, FeHAs display typical behaviour of superparamagnetic NPs without a residual magnetization at room temperature and with mass magnetization at saturation of 8.7 emu g −1 after subtraction of the paramagnetic contribution [ 16 , 36 ]. Details of the mechanisms occurring at the nano/atomic scale in determining the unusual magnetic features of FeHAs which exhibit a very high net magnetic moment per iron atom equal to 130 emu g −1 of Fe have been described elsewhere [ 16 ].…”
Section: Resultsmentioning
confidence: 98%
See 1 more Smart Citation
“…FeHAs have essentially been characterized in a previous work [ 16 ]. According to the earlier reported magnetic characterizations, FeHAs display typical behaviour of superparamagnetic NPs without a residual magnetization at room temperature and with mass magnetization at saturation of 8.7 emu g −1 after subtraction of the paramagnetic contribution [ 16 , 36 ]. Details of the mechanisms occurring at the nano/atomic scale in determining the unusual magnetic features of FeHAs which exhibit a very high net magnetic moment per iron atom equal to 130 emu g −1 of Fe have been described elsewhere [ 16 ].…”
Section: Resultsmentioning
confidence: 98%
“…The results obtained pave the way for the possible use of FeHAs and MEBD for the treatment of CVDs, where external magnetic stimuli might be applied to selectively trigger the release of drugs from the nano-carriers at the heart level and without altering the physiological function of the myocardium. FeHAs were selected among the existing MNPs because they have a lower content of iron compared to SPIONs (about 10 wt% versus 71 wt%) [ 36 ] and for their potential cardio-compatibility, as recently shown by our group for the undoped non-magnetic CaPs [ 4 , 6 ]. In fact, without promoting toxicity or interfering with any functional properties of cardiomyocytes, CaPs were shown in vitro and in vivo to safely and successfully cross the cardiomyocyte cellular membrane and release bioactive molecules (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…[ 156 ] Both CPMV and CCMV were tested in a wide variety of tissues, including the liver, spleen, bladder, and salivary glands, but showed no toxicity despite their broad biodistributions. [ 157 ] Unlike some synthetic NPs that remain in the body for weeks or even longer, [ 158,159 ] VLPs are subject to proteolytic degradation and are thus removed safely from the body within days. [ 115,129,160 ]…”
Section: Toxicity Biodistribution and Immunogenicity Of Vlpsmentioning
confidence: 99%
“…To deliver IO nanoparticles into the body, nano-and submicron-sized calcium phosphates (CaP) particles loaded with IO nanoparticles have been developed [7][8][9]. These CaP particles are able to carry a large number of IO nanoparticles; hence are expected to deliver IO nanoparticles to the target site efficiently when having a suitable surface and geometry.…”
Section: Introductionmentioning
confidence: 99%