On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

Adamiano, Alessio; Iafisco, Michele; Sandri, Monica; Basini, Martina; Arosio, Paolo; Canu, Tamara; Sitia, Giovanni; Esposito, Antonio; Iannotti, V.; Ausanio, G.; Fragogeorgi, Eirini; Rouchota, Maritina; Loudos, George; Lascialfari, A.; Tampieri, Anna

doi:10.1016/j.actbio.2018.04.040

Cited by 51 publications

(37 citation statements)

References 61 publications

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“…FeHAs have essentially been characterized in a previous work [ 16 ]. According to the earlier reported magnetic characterizations, FeHAs display typical behaviour of superparamagnetic NPs without a residual magnetization at room temperature and with mass magnetization at saturation of 8.7 emu g −1 after subtraction of the paramagnetic contribution [ 16 , 36 ]. Details of the mechanisms occurring at the nano/atomic scale in determining the unusual magnetic features of FeHAs which exhibit a very high net magnetic moment per iron atom equal to 130 emu g −1 of Fe have been described elsewhere [ 16 ].…”

Section: Resultsmentioning

confidence: 98%

“…The results obtained pave the way for the possible use of FeHAs and MEBD for the treatment of CVDs, where external magnetic stimuli might be applied to selectively trigger the release of drugs from the nano-carriers at the heart level and without altering the physiological function of the myocardium. FeHAs were selected among the existing MNPs because they have a lower content of iron compared to SPIONs (about 10 wt% versus 71 wt%) [ 36 ] and for their potential cardio-compatibility, as recently shown by our group for the undoped non-magnetic CaPs [ 4 , 6 ]. In fact, without promoting toxicity or interfering with any functional properties of cardiomyocytes, CaPs were shown in vitro and in vivo to safely and successfully cross the cardiomyocyte cellular membrane and release bioactive molecules (i.e.…”

Section: Discussionmentioning

confidence: 99%

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A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

Marrella

Iafisco

Adamiano

et al. 2018

J. R. Soc. Interface.

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Alternative drug delivery approaches to treat cardiovascular diseases are currently under intense investigation. In this domain, the possibility to target the heart and tailor the amount of drug dose by using a combination of magnetic nanoparticles (NPs) and electromagnetic devices is a fascinating approach. Here, an electromagnetic device based on Helmholtz coils was generated for the application of low-frequency magnetic stimulations to manage drug release from biocompatible superparamagnetic Fe-hydroxyapatite NPs (FeHAs). Integrated with a fluidic circuit mimicking the flow of the cardiovascular environment, the device was efficient to trigger the release of a model drug (ibuprofen) from FeHAs as a function of the applied frequencies. Furthermore, the biological effects on the cardiac system of the identified electromagnetic exposure were assessed in vitro and in vivo by acute stimulation of isolated adult cardiomyocytes and in an animal model. The cardio-compatibility of FeHAs was also assessed in vitro and in an animal model. No alterations of cardiac electrophysiological properties were observed in both cases, providing the evidence that the combination of low-frequency magnetic stimulations and FeHAs might represent a promising strategy for controlled drug delivery to the failing heart.

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

Marrella

Iafisco

Adamiano

et al. 2018

J. R. Soc. Interface.

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“…[ 156 ] Both CPMV and CCMV were tested in a wide variety of tissues, including the liver, spleen, bladder, and salivary glands, but showed no toxicity despite their broad biodistributions. [ 157 ] Unlike some synthetic NPs that remain in the body for weeks or even longer, [ 158,159 ] VLPs are subject to proteolytic degradation and are thus removed safely from the body within days. [ 115,129,160 ]…”

Section: Toxicity Biodistribution and Immunogenicity Of Vlpsmentioning

confidence: 99%

Virus‐Like Particles as Theranostic Platforms

Sun

Cui

2020

Advanced Therapeutics

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In recent years, theranostics have received enormous attention for their use in individualized diagnosis and treatment. The ability of viral coat protein subunits to assemble hierarchically can be used to package various kinds of foreign compounds. Moreover, numerous chemistries and modification strategies allow the functionalization of these virus-like particles (VLPs) with imaging reagents, targeting ligands, or therapeutic molecules. VLP nanoplatforms have great potential utility in the design of sophisticated multifunctional theranostic platforms. Numerous studies have reported the construction of multifunctional nanoparticles using VLPs for targeted diagnoses and treatment. In this paper, the latest progress in molecular imaging, drug delivery, and multifunctional theranostic nanodevices based on VLPs is reviewed.

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“…To deliver IO nanoparticles into the body, nano-and submicron-sized calcium phosphates (CaP) particles loaded with IO nanoparticles have been developed [7][8][9]. These CaP particles are able to carry a large number of IO nanoparticles; hence are expected to deliver IO nanoparticles to the target site efficiently when having a suitable surface and geometry.…”

Section: Introductionmentioning

confidence: 99%

Structural Analysis of Calcium Phosphate-Based Submicrospheres with Internally-Crystallized Iron Oxide Nanoparticles Fabricated by a Laser-Assisted Precipitation Process

Nakamura

Oyane

2019

Materials

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Calcium phosphate (CaP)-based submicrospheres containing magnetic iron oxide (IO) nanoparticles (IO–CaP submicrospheres) have potential for various biomedical applications. We recently achieved facile one-pot fabrication of IO–CaP submicrospheres using a laser-assisted precipitation process in which weak pulsed laser irradiation was applied to a labile CaP reaction mixture supplemented with ferrous ions under adequate pH. In this study, we performed cross-sectional transmission electron microscopy (TEM) analysis of the resulting IO–CaP submicrospheres. The cross-sectional TEM analysis revealed that the IO–CaP submicrospheres were heterogeneous in their internal nanostructures and could be categorized into two types, namely types A and B. The type A submicrospheres contained single nano-sized IO nanoparticles homogeneously dispersed throughout the CaP-based matrix. The type B submicrospheres contained larger IO nanoparticles with an irregular or spherical shape, which were mostly a few tens of nanometers in size along with one or two submicron-sized domains. These findings provide new insight into the formation mechanism of IO–CaP submicrospheres in this fabrication technique as well as future applications of the resulting IO–CaP submicrospheres.

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On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

Cited by 51 publications

References 61 publications

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

Virus‐Like Particles as Theranostic Platforms

Structural Analysis of Calcium Phosphate-Based Submicrospheres with Internally-Crystallized Iron Oxide Nanoparticles Fabricated by a Laser-Assisted Precipitation Process

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