Virus‐Like Particles as Theranostic Platforms

Sun, Xiao; Cui, Zongqiang

doi:10.1002/adtp.201900194

Cited by 20 publications

(12 citation statements)

References 156 publications

(201 reference statements)

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“…Most importantly, one of the ELP‐CCMV variants could be isolated from E. coli in a self‐assembled state, indicating that the ELP domain stabilizes empty CCMV capsids to such an extent that self‐assembly in vivo could be possible. In addition, although CCMV nanoreactors have not yet been used as artificial organelles in vivo , promising developments towards therapeutic use of these capsids [201] indicate that in vivo use is feasible. Hence, combining the discussed enzyme loading and cargo‐independent capsid stabilization strategies could lead to CCMV‐based artificial organelles in the future.…”

Section: Artificial Organelles Produced In Vivomentioning

confidence: 99%

Artificial Organelles: Towards Adding or Restoring Intracellular Activity

2021

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Compartmentalization is one of the main characteristics that define living systems. Creating a physically separated microenvironment allows nature a better control over biological processes, as is clearly specified by the role of organelles in living cells. Inspired by this phenomenon, researchers have developed a range of different approaches to create artificial organelles: compartments with catalytic activity that add new function to living cells. In this review we will discuss three complementary lines of investigation. First, orthogonal chemistry approaches are discussed, which are based on the incorporation of catalytically active transition metal‐containing nanoparticles in living cells. The second approach involves the use of premade hybrid nanoreactors, which show transient function when taken up by living cells. The third approach utilizes mostly genetic engineering methods to create bio‐based structures that can be ultimately integrated with the cell's genome to make them constitutively active. The current state of the art and the scope and limitations of the field will be highlighted with selected examples from the three approaches.

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Section: Artificial Organelles Produced In Vivomentioning

confidence: 99%

Artificial Organelles: Towards Adding or Restoring Intracellular Activity

2021

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“…The first category describes a method for harvesting the empty capsids being fabricated as by‐products of the infected cells. [ 159 ] One interesting VLP, hepatitis B VLP (HBV VLP), is used for the development of vaccine and drug delivery platforms. The exterior shell of HBV VLP can be easily modified with targeted moieties, such as site‐specific protein conjugation with SpyCatcher, while surface spikes are four‐helix bundles of the hepatitis dimer.…”

Section: Nanocarriersmentioning

confidence: 99%

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

et al. 2021

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In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA‐based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists’ enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology‐assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in‐depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology‐mediated RNA therapies are discussed.

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“…Direct injection of replication-competent virus will destroy the host cells. − Therefore, VLPs serving as alternatives for construction of drug delivery systems have been developed. Virus assembly such as TMV assembly is induced by the origin of assembly (OAS).…”

Section: Applications Of Virus or Viruslike Structuresmentioning

confidence: 99%

Virus-Based Supramolecular Structure and Materials: Concept and Prospects

Hou

Jiang

et al. 2021

ACS Appl. Bio Mater.

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Rodlike and spherelike viruses are various monodisperse nanoparticles that can display small molecules or polymers with unique distribution following chemical modifications. Because of the monodisperse property, aggregates in synthetic protein−polymer nanoparticles could be eliminated, thus improving the probability for application in protein−polymer drug. In addition, the monodisperse virus could direct the growth of metal materials or inorganic materials, finding applications in hydrogel, drug delivery, and optoelectronic and catalysis materials. Benefiting from the advantages, the virus or viruslike particles have been widely explored in the field of supramolecular chemistry. In this review, we describe the modification and application of virus and viruslike particles in surpramolecular structures and biomedical research.

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Virus‐Like Particles as Theranostic Platforms

Cited by 20 publications

References 156 publications

Artificial Organelles: Towards Adding or Restoring Intracellular Activity

Artificial Organelles: Towards Adding or Restoring Intracellular Activity

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

Virus-Based Supramolecular Structure and Materials: Concept and Prospects

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