On the use of substandard medicines in hematology: An emerging concern in the Middle East and North Africa region

Mattar, Mervat; Safety,

doi:10.1016/j.ejim.2017.08.003

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…This community may opt for labor outside appropriate health settings and even may encourage the use of non-conventional medications given by non-health professionals. A significant factor during the study period was the travel restriction and fear of infection associated with the COVID-19 pandemic, which occurred during the study period ( 18 , 19 , 20 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal and neonatal outcomes in adolescent pregnant women with one prior Cesarean section in Baghdad

Jasim¹,

Al-Momen²,

Wahbi³

et al. 2023

J Turkish German Gynecol Assoc

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Objective: Repeat adolescent pregnancy is a hot topic worldwide and imposes a challenge on the health system, especially when faced with limited resources. We aimed to assess maternal and neonatal outcomes in adolescent pregnant women with one prior cesarean section (CS). Material and Methods: Singleton adolescent pregnant women with one prior CS scar were recruited and divided into two groups based on the obstetric decision for delivery and/or mother’s wish, either trial of labor (TL) or elective cesarean section (ECS). If TL failed, an emergency CS was performed. Results: Out of the total 109 involved women, TL and ECS groups included 78 (71.6%) and 31 (28.4%) women, respectively. Emergency CS was done for 57 (52.3%) women from the TL group, leaving only 21 (19.3%) women with successful TL who had statistically significant (non-recurrent) indications of the prior CS [12 (57.1%)]. Malpresentation (n=24; 77.4%) was the major indication in the ECS group, while fetal distress (n=29; 50.9%) was the main cause of failed TL. Total maternal morbidities in the TL group were significantly higher for adjusted [1.5 (1.1-4.2)] and non-adjusted odds ratios (OR) [2.4 (1.6-5.6)]. Neonatal complications, such as admission to neonatal intensive care unit, were higher in the TL group without reaching significance. However, the adjusted OR [1.9 (1.1-3.3)] for perinatal asphyxia was significantly increased in TL group. Conclusion: Maternal morbidities and perinatal asphyxia were significantly higher in the TL group of adolescent women compared with the ECS group in this study.

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Section: Discussionmentioning

confidence: 99%

Maternal and neonatal outcomes in adolescent pregnant women with one prior Cesarean section in Baghdad

Jasim¹,

Al-Momen²,

Wahbi³

et al. 2023

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

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“…Our sample of patient had even higher iron content, which is in line with other reports from Middle East 3 , 14 . This might be due to compliance deterioration, background cultural beliefs, possible side effects of iron chelating drugs, and the frequent use of mimic medications in this part of the world 22 .…”

Section: Discussionmentioning

confidence: 99%

Green tea influence on iron overload in thalassemia intermedia patients: a randomized controlled trial

et al. 2020

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Background: Although iron chelation therapies have been available for many years for thalassemia intermedia patients, iron accumulation remains the major cause of death. Therefore, the need for additional chelation options is in demand. This randomized controlled study aimed to understand the effects of green tea on iron balance in thalassemia intermedia patients. Methods: Using a random selection method, 141 thalassemia intermedia patients were initially screened for inclusion in this trial; only 68 patients included after applying exclusion criteria. Two equal groups were generated (n=34/group): green tea (three cups/day after meals) + usual treatment (deferasirox iron chelator and on demand blood transfusion); and control (only usual treatment). The study lasted for a period of 12 months. Patients failing to comply to the trial methodology were excluded, leaving a final total of 29 patients in the green tea group and 28 patients in the control group. Liver iron concentration, and serum ferritin were assessed at baseline and 12 months, while hemoglobin levels were assessed monthly. Results: At baseline, both groups were matched regarding general demographics. At 12 months, the net drop of liver iron concentration in the green tea group (7.3 mg Fe/g dry weight) was significantly higher than the control group (4.6 mg Fe/g dry weight) (p<0.05). This was also seen with serum ferritin; net reduction in green tea and control groups were 1289 ng/ml and 871 ng/ml, respectively (p<0.05). Hemoglobin levels were slightly higher in the green tea group compared with the control group, but this was not significant. Conclusions: Regular green tea consumption had a significant capability to improve iron deposition in thalassemia intermedia patients who already undergo deferesirox iron chelation therapy. Trial registration: UMIN-CTR Clinical Trials Registry, UMIN000040841 (retrospectively registered June 21, 2020).

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On the use of substandard medicines in hematology: An emerging concern in the Middle East and North Africa region

Cited by 2 publications

References 8 publications

Maternal and neonatal outcomes in adolescent pregnant women with one prior Cesarean section in Baghdad

Maternal and neonatal outcomes in adolescent pregnant women with one prior Cesarean section in Baghdad

Green tea influence on iron overload in thalassemia intermedia patients: a randomized controlled trial

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