On the Transmission of Immunity from Mother to Offspring. A Study Upon Serum Hemolysins in Goats

Famulener, L. W.

doi:10.1093/infdis/10.3.332

Cited by 50 publications

(10 citation statements)

References 2 publications

(1 reference statement)

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“…Although Famulener (1912), working with goats, had concluded that the placenta was not permeable to maternal antibody, Ten broeck and Bauer (1923) in a study of women ( n = 6) known to be carriers of Clostridium tetani , showed that tetanus antitoxin was present in the mothers’ serum, placental cord blood, and children's serum. Despite the fact that they failed to account for the colostral contribution to serum antibody in the children, they concluded that ‘ Since the antitoxin level in the mother's and child's blood is at approximately the same level it seems probably that the placenta is permeable to this antibody.…”

Section: The Recognition Of Maternal Immunitymentioning

confidence: 99%

Historical and contemporary aspects of maternal immunity in swine

Poonsuk

Zimmerman

2017

Anim. Health. Res. Rev.

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Maternal immunity plays a pivotal role in swine health and production because piglets are born agammaglobulinemic and with limited cell-mediated immunity, i.e. few peripheral lymphoid cells, immature lymphoid tissues, and no effector and memory T-lymphocytes. Swine do not become fully immunologically competent until about 4 weeks of age, which means that their compromised ability to respond to infectious agents during the first month of life must be supplemented by maternal immune components: (1) circulating antibodies derived from colostrum; (2) mucosal antibodies from colostrum and milk; and (3) immune cells provided in mammary secretions. Because maternal immunity is highly effective at protecting piglets against specific pathogens, strengthening sow herd immunity against certain diseases through exposure or vaccination is a useful management tool for ameliorating clinical effects in piglets and delaying infection until the piglets' immune system is better prepared to respond. In this review, we discuss the anatomy and physiology of lactation, the immune functions of components provided to neonatal swine in mammary secretion, the importance of maternal immunity in the prevention and control of significant pathogens.

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Section: The Recognition Of Maternal Immunitymentioning

confidence: 99%

Historical and contemporary aspects of maternal immunity in swine

Poonsuk

Zimmerman

2017

Anim. Health. Res. Rev.

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“…TO THE CALF For many years, the importance of colostrum to the calf was thought to rest with its costive action (85), although Ehrlich (40), as early as 1892, demonstrated that immunity could be passed from the mother to the young via the milk. Ehrlich's observations and subsequent ones were summarized up to 1912 by Famulener (47) in an extensive review. Famulener, drawing upon the results of these previous experiments and his own, postulated that the young acquired their maternal passive immunity from the ingestion of antibodies contained in the colostrum.…”

Section: Transference Of Immunity From the Dammentioning

confidence: 99%

Escherichia coli and Neonatal Disease of Calves

Gay¹

1965

Bacteriological Reviews

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“…While their own adaptive immune system is maturing, neonates may get protection from the products of the adaptive immune system of the mother, which was first reported in 1892 [155]. One primary protective product is a protein family, called immunoglobulins or antibodies, which come from several sources and they are transported into milk by receptor-mediated processes, reflecting the antigenic stimulation of immunity of the mother [156].…”

Section: Functionalitymentioning

confidence: 99%

The Functional Power of the Human Milk Proteome

Zhu

Dingess

2019

Nutrients

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Human milk is the most complete and ideal form of nutrition for the developing infant. The composition of human milk consistently changes throughout lactation to meet the changing functional needs of the infant. The human milk proteome is an essential milk component consisting of proteins, including enzymes/proteases, glycoproteins, and endogenous peptides. These compounds may contribute to the healthy development in a synergistic way by affecting growth, maturation of the immune system, from innate to adaptive immunity, and the gut. A comprehensive overview of the human milk proteome, covering all of its components, is lacking, even though numerous analyses of human milk proteins have been reported. Such data could substantially aid in our understanding of the functionality of each constituent of the proteome. This review will highlight each of the aforementioned components of human milk and emphasize the functionality of the proteome throughout lactation, including nutrient delivery and enhanced bioavailability of nutrients for growth, cognitive development, immune defense, and gut maturation.

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On the Transmission of Immunity from Mother to Offspring. A Study Upon Serum Hemolysins in Goats

Cited by 50 publications

References 2 publications

Historical and contemporary aspects of maternal immunity in swine

Historical and contemporary aspects of maternal immunity in swine

Escherichia coli and Neonatal Disease of Calves

The Functional Power of the Human Milk Proteome

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