On the thermal noise limit of cellular membranes

Vincze, Gyula; Szász, Nóra; Szász, András

doi:10.1002/bem.20051

Cited by 30 publications

(37 citation statements)

References 24 publications

(33 reference statements)

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“…It is pertinent to infer that exposure to magnetic fields induces quite a variety of biological effects. Different waveform magnetic field sources results in varied biological effects on living systems, as their frequency spectrums are diverse [39,58,59]. …”

Section: Discussionmentioning

confidence: 99%

Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity

Rajendra¹,

Sujatha²,

Sashidhar³

et al. 2012

Biodiscovery

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The cell viability and DNA damage in unstimulated sheep primary lymphocytes subjected to different extremely low electromagnetic field intensities (5, 50 and 100 µT; 50 Hz) were studied with special emphasis on apoptosis. Sheep primary lymphocytes cultured in RPMI, supplemented with 10% FBS in the absence of mitogens, were exposed till 16 h. The cell viability assessment by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay showed a dose dependent enhancement of viability at 16 h. Further, quantitative DNA laddering and flow cytometric analysis showed a significant decrease in apoptosis of the cells subjected to 100 (p<0.01) and 50 µT (p<0.05) for 16 h as compared to control group. There was a statistically significant decrease (p<0.01) in the specific activity of caspase 9 at 100 µT in cells exposed for 16 h. However, no enhancement of DNA damage was observed at 5, 50 and 100 µT as evidenced by comet assay. Comet assay also confirmed the decreased cell death of exposed cells (100 µT). Experimental data suggests decreased apoptosis at 100 µT (50 Hz), possibly by the suppression of caspase 9 activity leading to the enhanced cell viability. Effect of ELF-EMF on primary lymphocytesBioDiscovery | www.biodiscoveryjournal.co.uk

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Section: Discussionmentioning

confidence: 99%

Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity

Rajendra¹,

Sujatha²,

Sashidhar³

et al. 2012

Biodiscovery

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“…In the ELF regime his noiseband vanished and thus allowed for the ''detection'' of typical power frequency fields by the cell membrane. Very recently, however, Vincze et al [2005] suggested revisions to Kaune's model. With these revisions the thermal noise power becomes larger and effectively white, that is, noise strength is independent of frequency.…”

Section: Introductionmentioning

confidence: 94%

“…With these revisions the thermal noise power becomes larger and effectively white, that is, noise strength is independent of frequency. In the model of Vincze et al [2005], ELF fields would once again be drowned out by thermal noise.…”

Section: Introductionmentioning

confidence: 98%

Gauging the strength of power frequency fields against membrane electrical noise

Bier

2005

Bioelectromagnetics

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The possible physiological effect of power frequency fields (60 Hz in the US, 50 Hz in most other countries) is still a hotly debated issue. These relatively slow fields distribute themselves across cell membranes and a common approach has been to compare the strength of these fields to the strength of the electric noise that the membrane generates itself through Brownian motion. However, there has been disagreement among researchers on how to evaluate the membrane electric noise. In the first part of this article three major models are discussed. In the second part an ab initio modeling of membrane electric fields finds that different manifestations of Brownian noise lead to an electric noise intensity that is many times larger than what conventional estimates have yielded. Finally, the legitimacy of gauging a nonequilibrium external signal against internal equilibrium noise is questioned.

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“…The proper selection uses the dipole relaxation of beta-dispersion connected to membrane-bound water [24]. This allows the zero-order electric-field action, which has no noise-induced thermal limit of the field [25]. The huge local dielectric permittivity of the transmembrane proteins and their clusters (rafts), are active in the electro-orientation of cells [26].…”

Section: Introductionmentioning

confidence: 99%

Nanoheating without Artificial Nanoparticles

Vincze

Andócs

et al. 2015

Biol Med (Aligarh)

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Our aim is to describe the physical and physiological effects of local modulated electro-hyperthermia (mEHT). The method concentrates on the energy absorption of cluster rafts of the plasma membrane. The targeted cluster contains transmembrane proteins, which can form coherent working voltage-gated ion channels and/or TRP receptors in one domain. This targeting is analogous to nanoparticle heating, except this uses readily available nanoparticles on the cell membrane instead of the artificially placed nano-object to induce selective energy absorption from the outside field. In the discussed non-artificial nanoparticle heating, selectivity is the consequence of the synergy of various interactions embedded into each other in their effective volume in macro-, micro-and nano-ranges.

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On the thermal noise limit of cellular membranes

Cited by 30 publications

References 24 publications

Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity

Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity

Gauging the strength of power frequency fields against membrane electrical noise

Nanoheating without Artificial Nanoparticles

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