Nanoheating without Artificial Nanoparticles

Vincze, Gyula; Gy, Szigeti; Andócs, Gábor; Szász, András

doi:10.4172/0974-8369.1000249

Cited by 6 publications

(4 citation statements)

References 73 publications

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“…Many researchers have investigated the effects of mEHT on various in vitro cell cultures and in vivo allografts and xenografts. Comparisons have shown significant differences between cells treated with the same temperature through mEHT and conventional hyperthermia [ 9 , 57 ], even in comparison to other capacitive techniques [ 58 ]. These studies highlight the differences between cancer cells and normal cells and the advantage of being able to destroy cancer cells selectively.…”

Section: Introductionmentioning

confidence: 99%

Modulated Electrohyperthermia: A New Hope for Cancer Patients

Alshaibi

Alshehri

Hassan

et al. 2020

BioMed Research International

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According to the World Health Organization, the prevalence of cancer has increased worldwide. Oncological hyperthermia is a group of methods that overheat the malignant tissues locally or systematically. Nevertheless, hyperthermia is not widely accepted, primarily because of the lack of selectivity for cancer cells and because the temperature-triggered higher blood flow increases the nutrient supply to the tumor, raising the risk of metastases. These problems with classical hyperthermia led to the development of modulated electrohyperthermia (mEHT). The biophysical differences of the cancer cells and their healthy hosts allow for selective energy absorption on the membrane rafts of the plasma membrane of the tumor cells, triggering immunogenic cell death. Currently, this method is used in only 34 countries. The effectiveness of conventional oncotherapies increases when it is applied in combination with mEHT. In silico, in vitro, and in vivo preclinical research studies have all shown the extraordinary ability of mEHT to kill malignant cells. Clinical applications have improved the quality of life and the survival of patients. For these reasons, many other research studies are presently in progress worldwide. Thus, the objective of this review is to highlight the capabilities and advantages of mEHT and provide new hopes for cancer patients worldwide.

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Section: Introductionmentioning

confidence: 99%

Modulated Electrohyperthermia: A New Hope for Cancer Patients

Alshaibi

Alshehri

Hassan

et al. 2020

BioMed Research International

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“…The thermal dose with temperature mapping is also shown in vivo, as well as the radiation equivalent of mEHT is estimated [45,46]. mEHT causes massive apoptosis by exciting the death-toll receptors and transient reaction-potential channels of the membrane [47,48]. The observed apoptotic cell-distraction is significantly more intensive with mEHT than with water-bath or other conventional capacitive coupling hyperthermia methods [49].…”

Section: Discussionmentioning

confidence: 99%

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Szász¹

2020

COR

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Hyperthermia treatment for solid tumors is a long-used, but poorly accepted method in clinical use. Modulated electro-hyperthermia (mEHT, trade name: oncothermia®) changes the paradigm, introduces a novel, cellularly selective and immunogenic cell-ruination. The mEHT method produces tumor-vaccination, presenting the unharmed genetic information of cancer cells to immune cells [1]. The mEHT method is approved in more than 30 countries. Its phase II/III clinical applications indicate a broad perspective.

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“…After the selection of the malignant tissue over the healthy tissue by mEHT (397), the energy absorption is focused in the malignant tissue. In a simulation on the nanoscopic effects on the cell membranes, Papp et al demonstrated regions of focused energy absorption (398) which are believed to be the clusters of transmembrane proteins (rafts) on the membranes of cancer cells (399,400). The malignant cells have relatively high raft density compared to the non-malignant neighbors (401), which appears to aid the selection further.…”

Section: Proposal For the Change Of Paradigmmentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

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Heating as a medical intervention in cancer treatment is an ancient approach, but effective deep heating techniques are lacking in modern practice. The use of electromagnetic interactions has enabled the development of more reliable localregional hyperthermia (LRHT) techniques whole-body hyperthermia (WBH) techniques. Contrary to the relatively simple physical-physiological concepts behind hyperthermia, its development was not steady, and it has gone through periods of failures and renewals with mixed views on the benefits of heating seen in the medical community over the decades. In this review we study in detail the various techniques currently available and describe challenges and trends of oncological hyperthermia from a new perspective. Our aim is to describe what we believe to be a new and effective approach to oncologic hyperthermia, and a change in the paradigm of dosing. Physiological limits restrict the application of WBH which has moved toward the mild temperature range, targeting immune support. LRHT does not have a temperature limit in the tumor (which can be burned out in extreme conditions) but a trend has started toward milder temperatures with immune-oriented goals, developing toward immune modulation, and especially toward tumor-specific immune reactions by which LRHT seeks to target the malignancy systemically. The emerging research of bystander and abscopal effects, in both laboratory investigations and clinical applications, has been intensified. Our present review summarizes the methods and results, and discusses the trends of hyperthermia in oncology.

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Nanoheating without Artificial Nanoparticles

Cited by 6 publications

References 73 publications

Modulated Electrohyperthermia: A New Hope for Cancer Patients

Modulated Electrohyperthermia: A New Hope for Cancer Patients

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Quo Vadis Oncological Hyperthermia (2020)?

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