On the study of the freeze–thaw thermal process of a biological system

Effects of freezing treatments on the fermentative activity and gluten network integrity of sweet dough

“…The external cellular solution increased, so a hyperosmotic environment was created and the extern ice crystals were formed. This loss of water had a direct influence on cell survival (Chua & Chou, 2009) and accelerated to relative increasing in vapor pressure of intracellular supercooled water (Mazur, 1970). Release of intracellular water provoked extreme conditions these cells could be dehydrated and plasmolysed.…”

Temperature distribution in multi-layer skin tissue in presence of a tumor

“…A significant amount of research in bioheat transfer over the past few decades has led to an understanding of the governing dynamics of thermal transport in a tissue [1][2][3]. A number of thermal based therapeutic measures have been developed and adopted in practice, including laser surgery, cryotherapy, magnetic nanoparticle based hyperthermia and radio frequency ablation [4][5][6][7][8][9]. The design and optimization of these procedures has been aided by advancements in the understanding of bioheat transfer.…”

“…The application of Pennes equation to magnetic fluid hyperthermia has been studied, where a theoretical solution is presented for a spherical tumor surrounded by a thin shell of magnetic nanoparticles [7]. An analytical model was proposed to investigate the rate of cell destruction during a freeze-thaw cryosurgical procedure, in order to minimize damage to healthy cells [5]. Steady state temperature distribution in a one dimensional cylindrical tissue has been developed for human limbs [18].…”

Simulation and evaluation of freeze-thaw cryoablation scenarios for the treatment of cardiac arrhythmias

“…Proper mathematical models allow for analyzing temperature distributions during cryoablation procedures without biases introduced by anatomical variations or the experimental setup. In a work of Chua and Chou, a computer model was created to study the thermal processes during cryoablation in porcine liver tissue [ 14 ]. In the simulations of this study, the impact of different thawing durations, thawing temperatures and number of freeze-thaw cycles on the ablated tissue was compared in terms of calculated ice volumes and cell survival signatures based on varying cooling and thawing rates.…”