On the structures of garcinol, isogarcinol and camboginol

Krishnamurthy, N.; Lewis, Y. S.; Ravindranath, B.

doi:10.1016/0040-4039(81)80154-2

Cited by 96 publications

(64 citation statements)

References 5 publications

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“…1A) is a polyprenylated acylphloroglucinole contained in the rind of Guttiferae (Garcinia indica, G. huillkensis and G. cambogia), named Kokum, which is used as culinary spice and garnish for curry. In India, Kokum is used in ayurvedic medicine for the treatment of inflammatory and infectious diseases [1]. In rats, garcinol protects against 4-nitroquinoline-1-oxide-induced tongue carcinogenesis [2] and azoxymethane-induced colon carcinogenesis [3].…”

Section: Introductionmentioning

confidence: 99%

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

Koeberle

Northoff

Werz

2009

Biochemical Pharmacology

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To cite this version:Andreas Koeberle, Hinnak Northoff, Oliver Werz. Identification of 5-lipoxygenase and microsomal prostaglandin E synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochemical Pharmacology, Elsevier, 2009, 77 (9) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 Ca 2+ -ionophore (A23187)-induced arachidonic acid release in neutrophils nor COX-2 activity in A549 cells or whole blood, measured as formation of 6-keto PGF 1α , or isolated human recombinant COX-2 were significantly affected by garcinol (≤ 30 µM). Together, the high potency of garcinol to selectively suppress PGE 2 synthesis and 5-lipoxygenase product formation provides a molecular basis for the anti-inflammatory and anti-carcinogenic effects of garcinol and rationalizes its therapeutic use.

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Section: Introductionmentioning

confidence: 99%

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

Koeberle

Northoff

Werz

2009

Biochemical Pharmacology

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“…Down-regulation was associated with enhanced apoptosis by cytokine and chemotherapeutic agents. [55] Garcinia indica (Thouars) Choisy: Garcinia indica extracts, especially from the rind, are rich in polyisoprenylated benzophenone derivatives such as garcinol [56] . Garcinol shows strong antioxidant activity which has been credited to both phenolic hydroxyl groups as well as a β-diketone moiety [57,58] .…”

Section: Synonym -Woodfordia Floribundamentioning

confidence: 99%

Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

Sekhar¹,

Ruma²,

Kini³

et al. 2012

Phcog Commn

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“…To our knowledge, no chemical investigation of G. bancana has been reported. This investigation led to the isolation and structural elucidation of one new biphenyl derivative (1) and seven known compounds from the twigs; two prenylated benzophenones [garcinol and isogarcinol], [2][3][4][5] …”

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confidence: 99%