2005
DOI: 10.1007/s11084-005-1078-4
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On the Structural Regularity in Nucleobases and Amino Acids and Relationship to the Origin and Evolution of the Genetic Code

Abstract: To explore how chemical structures of both nucleobases and amino acids may have played a role in shaping the genetic code, numbers of sp2 hybrid nitrogen atoms in nucleobases were taken as a determinative measure for empirical stereo-electronic property to analyze the genetic code. Results revealed that amino acid hydropathy correlates strongly with the sp2 nitrogen atom numbers in nucleobases rather than with the overall electronic property such as redox potentials of the bases, reflecting that stereo-electro… Show more

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Cited by 9 publications
(3 citation statements)
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“…Such strict correspondence could be easily understood if some kind of fit existed between nucleic acid pockets and amino acids. This stereo-chemical hypothesis might be responsible for some of the correspondences (Yang 2005;Legiewicz and Yarus 2005). In fact, the correspondences are mediated by adaptor RNA molecules, the transfer RNAs (tRNA), each one carrying a specific amino acid and bearing a code, a triplet of nucleotides (an anticodon) that matches by base-pairing a triplet in the template mRNA (the codon; Ibba et al 2000;Barbieri 2003).…”
Section: The Coded Biotic Worldmentioning
confidence: 99%
“…Such strict correspondence could be easily understood if some kind of fit existed between nucleic acid pockets and amino acids. This stereo-chemical hypothesis might be responsible for some of the correspondences (Yang 2005;Legiewicz and Yarus 2005). In fact, the correspondences are mediated by adaptor RNA molecules, the transfer RNAs (tRNA), each one carrying a specific amino acid and bearing a code, a triplet of nucleotides (an anticodon) that matches by base-pairing a triplet in the template mRNA (the codon; Ibba et al 2000;Barbieri 2003).…”
Section: The Coded Biotic Worldmentioning
confidence: 99%
“…The association between codons and amino acids could have been affected by the element composition and M (Rosen 1999), by the number of carbon atoms in amino acid side chains (β-carbons), and by the number of C=N bonds in heterocyclic bases: three in A, two in G, one in C, and zero in U (Yang 2005). These stereoelectronic factors might have contributed significantly to the development of symmetry in the genetic code.…”
Section: Early Stages Of Genetic Code Developmentmentioning
confidence: 99%
“…Such strict correspondence could be easily understood if some kind of fit existed between nucleic acid surfaces or pockets and the amino acids. This stereochemical hypothesis is not presently in favor for the generation of the whole code but it could have been responsible for some of the correspondences (Yang 2005;Yarus et al 2005). In fact, the correspondences are mediated by adaptor RNA molecules, the transfer RNAs (tRNA), each one carrying a specific amino acid and bearing a code, a triplet of nucleotides (an anticodon) that matches by base-pairing a triplet in the template mRNA (the codon) (Ibba et al 2000;Barbieri 2003).…”
mentioning
confidence: 99%