On-the-spot quenching for effective implementation of cooling crystallization in a continuous-flow microfluidic device

Abstract

Illustrated is a microfludic cooling crystallization device that can effectively screen polymorphs, growth rates, and morphology of crystalline materials.

Primary and Secondary Nucleation Threshold of Succinic Acid: From the Perspective of Dimensionless Solid–Liquid Interfacial Tension

“…Modified Sangwal's Theory. Sangwal 64 uses the theory of regular solutions and the classical theory of threedimensional nucleation to predict a linear dependence of (T 0 / ΔT max ) 2 on lnR, which can be extended to explain the value of MSZW by the isothermal method and to explain the effect of saturation temperature and impurities on MSZW. The detailed derivation process can be found in ref 64.…”

“…Continuous intelligent manufacturing, − especially continuous crystallization, has been receiving increasing attention in the field of chemical engineering, which plays an important role in realizing green, continuous, and efficient production processes in industrialization. , Crystallization is an important separation and purification technology, which is widely used in the fields of pharmaceutical, , chemical industry, food, semiconductor, ceramic, metal, and other materials. , Therefore, crystallization is a common operation in chemical processes and often used to purify and separate organic − and inorganic − compounds.…”

Nucleation control and separation of ethyl maltol polymorphs under different growth conditions through solution crystallization process in selected solvent environments

“…Therefore, it is essential to identify elegant methods for the nucleation and isolation of the ethyl maltol polymorphs from solutions with different solvent environments. 11,12 The present investigation adopted different crystallization methodologies such as fast evaporation, slow evaporation, and quench cooling methods at different solvent environments to induce the nucleation of all three polymorphic forms of ethyl maltol (Form-I, Form-II & Form-III) at appropriate supersaturation conditions and their separation. Morphologies of the nucleated polymorphs were confirmed through in situ optical microscopic analysis and by theoretical predictions using shape software and the Bravais-Friedel-Donnay-Harker (BFDH) model.…”

In-line measurement of liquid–liquid phase separation boundaries using a turbidity-sensor-integrated continuous-flow microfluidic device

“…In this study, an easy-to-adapt and affordable photosensitive turbidity sensor was developed and integrated into a novel continuous-flow microfluidic device for detecting the LLPS boundaries. [20][21][22][23][24] The continuous-flow microfluidic device provides uniform mixing by inducing cyclonic flow inside the micromixer. The turbidity sensor consists of a photodiode as the detector and an infrared light-emitting diode (LED) light that provides the light source.…”