In-line measurement of liquid–liquid phase separation boundaries using a turbidity-sensor-integrated continuous-flow microfluidic device

Coliaie, Paria; Prajapati, Aditya; Ali, Rabia; Boukerche, Moussa; Korde, Akshay; Kelkar, Manish S.; Nere, Nandkishor K.; Singh, Meenesh R.

doi:10.1039/d1lc01112j

Cited by 2 publications

(2 citation statements)

References 31 publications

(44 reference statements)

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“…The device employs uniform mixing using cyclonic flow in a micromixer and utilizes a turbidity sensor comprising an infrared LED light source and a photodiode. By adjusting the flow rates of the solvent, antisolvent, and solute streams, the device allows for precise detection of binodal points in the liquid–liquid phase diagram, presenting an efficient and high-throughput approach for liquid–liquid phase separation detection in drug development and biotechnology applications [ 133 ].…”

Section: Spectroscopy-based Detection Techniquesmentioning

confidence: 99%

“…Coliaie et al, developed a continuous-flow microfluidic device with an integrated turbidity sensor, facilitating the in-line measurements of liquid-liquid phase separation boundaries of two ternary systems: β-alanine-water-isopropyl alcohol at room temperature and β-alanine-water-ethanol at 50 • C. The device employs uniform mixing using cyclonic flow in a micromixer and utilizes a turbidity sensor comprising an infrared LED light source and a photodiode. By adjusting the flow rates of the solvent, antisolvent, and solute streams, the device allows for precise detection of binodal points in the liquid-liquid phase diagram, presenting an efficient and high-throughput approach for liquid-liquid phase separation detection in drug development and biotechnology applications [133].…”

Section: Light Extinction Spectrometry (Les)-turbidimetrymentioning

confidence: 99%

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On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

Kurdadze,

Lamadie,

Nehme

et al. 2024

Sensors

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Microfluidics has emerged as a robust technology for diverse applications, ranging from bio-medical diagnostics to chemical analysis. Among the different characterization techniques that can be used to analyze samples at the microfluidic scale, the coupling of photonic detection techniques and on-chip configurations is particularly advantageous due to its non-invasive nature, which permits sensitive, real-time, high throughput, and rapid analyses, taking advantage of the microfluidic special environments and reduced sample volumes. Putting a special emphasis on integrated detection schemes, this review article explores the most relevant advances in the on-chip implementation of UV–vis, near-infrared, terahertz, and X-ray-based techniques for different characterizations, ranging from punctual spectroscopic or scattering-based measurements to different types of mapping/imaging. The principles of the techniques and their interest are discussed through their application to different systems.

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Section: Spectroscopy-based Detection Techniquesmentioning

confidence: 99%

Section: Light Extinction Spectrometry (Les)-turbidimetrymentioning

confidence: 99%