On the significance of anaphylactic catecholamine release in guinea pigs

Bernauer, W.; Filipowski, P.

doi:10.1007/bf00500776

Cited by 7 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the combination of the a-receptor blocker dibenamine with adrenaline exerted a beneficial action. A marked increase in survival rate and times was obtained, con firming previous findings of Bernauer and Filipowski [1973], The dibenamine dose used (5 mg/kg) suppressed the pressure ef fect of the adrenaline infusion only partial ly. Higher dibenamine doses are per se dele terious for anaphylactic animals [Bernauer and Filipowski, 1973].…”

Section: Discussionsupporting

confidence: 65%

“…A marked increase in survival rate and times was obtained, con firming previous findings of Bernauer and Filipowski [1973], The dibenamine dose used (5 mg/kg) suppressed the pressure ef fect of the adrenaline infusion only partial ly. Higher dibenamine doses are per se dele terious for anaphylactic animals [Bernauer and Filipowski, 1973]. It is known that ex tensive blockade of the a-receptors makes the circulation highly vulnerable to hypovo lemia, and the latter indeed occurs in the protracted shock [Bernauer and Schanz, 1974], It seems likely that the beneficial ef fect of the combination of dibenamine/adrenaline was essentially caused by an im provement of the peripheral tissue perfusion due to the predominating /?-receptor stimu lation.…”

Section: Discussionsupporting

confidence: 65%

“…Since, according to previous findings [Bernauer and Schanz, 1974], the protract ed shock is accompanied by low arterial pressures, the exogenous supply of vaso pressor catecholamines appeared to be use ful. However, adrenaline did not decrease, but even increased, the death rate [Bernauer and Filipowski, 1973]. Therefore, the circu latory effects of adrenaline, which is re leased endogenously in considerable amounts during protracted anaphylactic shock [Bernauer et al, , 1975, have been elucidated by using «-receptor, as well as /3-receptor, blocking agents.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Catecholamines and Sympatholytics on Survival and Circulatory Parameters in Protracted Anaphylactic Shock of Guinea Pigs

Molls¹,

Bernauer²

1976

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

Protracted anaphylactic shock of guinea pigs led to death in over 90% of the animals, and good protection was obtained with an infusion of adrenaline after dibenamine pretreatment. Adrenaline alone, in doses which prevented the anaphylactic fall of arterial blood pressure, had no beneficial effect. Practolol abolished the therapeutic action of the combination of dibenamine/adrenaline. Stimulation of β-receptors by isoproterenol did not increase the survival rate. With dopamine, however, a significant prolongation of the survival times was obtained.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Catecholamines and Sympatholytics on Survival and Circulatory Parameters in Protracted Anaphylactic Shock of Guinea Pigs

Molls¹,

Bernauer²

1976

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The method of immunization described by Anderson [11] and that reported by Bernauer and Filipowskii [12] to develop protracted anaphylactic shock in guinea pigs was used. Animals of both sexes weighting 400 to 500 g were injected i.p.…”

Section: Protracted Anaphylactic Shock Mediated By Igg In Guinea Pigsmentioning

confidence: 99%

The effect of disodium 4-chloro-2-iminodibenzoate (CCA) on IgE levels and anaphylactic shock

1989

View full text Add to dashboard Cite

The effect of disodium 4-chloro-2,2-iminodibenzoate (CCA) on IgE antibody response was examined in C3H/A and (BALB/c x C57BL/6J) F1 hybrid mice immunized with low doses of ovalbumin (OA) adsorbed on aluminium hydroxide gel. CCA administered orally at the doses of 5 and 50 mg/kg/day reduced IgE antibody production in these mice as determined by PCA test. High doses of CCA (100 mg/kg/day) given from day 7 before immunization of C57BL mice and during 1 week after immunization of mice with OA and Bordetella Pertussis Vaccine reduced the mortality of these mice subjected to anaphylactic shock on day 7 of immunization. CCA treatment was ineffective in anaphylactic shock of C57BL mice immunized with very high dose of OA, known to elicit little or no IgE antibody production but high IgG antibody response. The treatment of OA-immunized Guinea pigs with one oral dose of CCA (100 mg/kg) did not reduce mortality in protracted anaphylactic shock. Our results demonstrate that CCA inhibits IgE production as well as IgE mediated hypersensitivity reactions in mice.

show abstract

“…Piper et al (1967) and Bernaucr et al (1971) have shown that during guinea pig anaphylaxis adrenaline is released in considerable amounts. In view of the findings of Collier and James (1967), Bernauer et al (1970), Hahn et al (1970), and Bernauer and Filipowski (1973) one can suppose that the adrenaline release represents a contraregulatory mechanism.…”

Section: Introductionmentioning

confidence: 96%

Plasma corticosteroid levels in anaphylactic shock of guinea pigs

Bernauer

Liebig

1973

Res. Exp. Med.

Self Cite

View full text Add to dashboard Cite

Summary. Plasma l l-hydroxycorticosteroid levels were measured fluorometrically during anaphylaetic shock of guinea pig s.Whereas in the acute anaphylaetic reaction elicited by i.v. injection of antigen, no increase was observed, a highly significant rise of plasma eorticosteroids was found in the so-called protracted shock.Pretreatment with the a-receptor blocking agent, phentolamine, reduced the plasma eorticosteroid levels in the protracted shock significantly. Antihistaminics, and propranolol, had no inhibitory effect.Key words: Cortieosteroids --Anaphylactic shock --Catecholamines.Zusammen/assung. Die ll-Hydroxycortieosteroid-Konzentrationen im Plasma anaphylaktischer Meerschweinchen wurden fluorometriseh gemessen.Im akuten anaphylaktischen Schock, der dureh i.v. Gabe yon Antigen ausgelSst wurde, waren die Plasmaspiegel nicht erhSht, w~hrend im sog. protrahierten Schock ein hochsignifikanter Anstieg gemessen wurde.Vorbehandlung mit dem a-Receptorenblocker Phentolamin verminderte die Corticosteroidspiegel im protrahierten Schock signifikant, w~hrend Propranolol sowie Antihistaminica keinen Hemmeffekt hatten.SchliisselwSrter: Corticosteroide --Anaphylaktischer Schoek --Katecholamine.

show abstract

On the significance of anaphylactic catecholamine release in guinea pigs

Cited by 7 publications

References 15 publications

Effect of Catecholamines and Sympatholytics on Survival and Circulatory Parameters in Protracted Anaphylactic Shock of Guinea Pigs

Effect of Catecholamines and Sympatholytics on Survival and Circulatory Parameters in Protracted Anaphylactic Shock of Guinea Pigs

The effect of disodium 4-chloro-2-iminodibenzoate (CCA) on IgE levels and anaphylactic shock

Plasma corticosteroid levels in anaphylactic shock of guinea pigs

Contact Info

Product

Resources

About