On the relationship between cortical excitability and visual oscillatory responses — A concurrent tDCS–MEG study

Marshall, Tom R.; Esterer, Sophie; Herring, Jim; Bergmann, Til Ole; Jensen, Ole

doi:10.1016/j.neuroimage.2015.09.069

Cited by 40 publications

(64 citation statements)

References 65 publications

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“…Investigators have attempted to quantify the nature of tDCS effects on physiology using EEG (e.g., (Gall et al, 2015; Reinhart & Woodman, 2015; Reinhart, Zhu, Park, & Woodman, 2015)), fMRI (e.g., (Alekseichuk, Diers, Paulus, & Antal, 2015; Amadi, Ilie, Johansen-Berg, & Stagg, 2013; Antal, Polania, Schmidt-Samoa, Dechent, & Paulus, 2011; Hilgenstock, Weiss, Huonker, & Witte, 2016; Hunter et al, 2015; Spiegel et al, 2013)), and MEG (Garcia-Cossio et al, 2015; Hanley, Singh, & McGonigle, 2015; Marshall, Esterer, Herring, Bergmann, & Jensen, 2015; Soekadar et al, 2013). However, there has been little consensus across studies, especially those with similar task parameters.…”

Section: Introductionmentioning

confidence: 99%

“…Of particular relevance to the current study, research shows that anodal tDCS over the occipital cortices increases offline visual evoked potentials (Antal, Kincses, Nitsche, Bartfai, & Paulus, 2004; Strigaro, Mayer, Chen, Cantello, & Rothwell, 2015), as well as online BOLD activation during visual perception (Alekseichuk et al, 2015). However, two recent MEG-tDCS studies attempted to identify online oscillatory alterations in the visual cortex during occipital tDCS, and both reported largely null results (Hanley et al, 2015; Marshall et al, 2015). In fact, the eloquent study by Hanley and colleagues showed that occipital gamma oscillations were only modulated during tDCS when the stimulation was applied using an electrode configuration distant from the occipital cortex (i.e., involving the motor and frontal cortices, (Hanley et al, 2015)), whereas the study by Marshall et al reported no differences in induced oscillatory during anodal or cathodal occipital stimulation (Marshall et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…However, two recent MEG-tDCS studies attempted to identify online oscillatory alterations in the visual cortex during occipital tDCS, and both reported largely null results (Hanley et al, 2015; Marshall et al, 2015). In fact, the eloquent study by Hanley and colleagues showed that occipital gamma oscillations were only modulated during tDCS when the stimulation was applied using an electrode configuration distant from the occipital cortex (i.e., involving the motor and frontal cortices, (Hanley et al, 2015)), whereas the study by Marshall et al reported no differences in induced oscillatory during anodal or cathodal occipital stimulation (Marshall et al, 2015). Only two other studies have utilized tDCS and MEG, but the goal of these studies was to evaluate whether online tDCS artifacts precluded accurate MEG source reconstruction (Garcia-Cossio et al, 2015; Soekadar et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study

Heinrichs‐Graham

McDermott²,

Mills³

et al. 2017

Cortex

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Transcranial direct-current stimulation (tDCS) is a noninvasive neuromodulatory method that involves delivering low amplitude, direct current to specific regions of the brain. While a wealth of literature shows changes in behavior and cognition following tDCS administration, the underlying neuronal mechanisms remain largely unknown. Neuroimaging studies have generally used fMRI and shown only limited consensus to date, while the few electrophysiological studies have reported mostly null or counterintuitive findings. The goal of the current investigation was to quantify tDCS-induced alterations in the oscillatory dynamics of visual processing. To this end, we performed either active or sham tDCS using an occipital-frontal electrode configuration, and then recorded magnetoencephalography (MEG) offline during a visual entrainment task. Significant oscillatory responses were imaged in the time-frequency domain using beamforming, and the effects of tDCS on absolute and relative power were assessed. The results indicated significantly increased basal alpha levels in the occipital cortex following anodal tDCS, as well as reduced occipital synchronization at the second harmonic of the stimulus-flicker frequency relative to sham stimulation. In addition, we found reduced power in brain regions near the cathode (e.g., right inferior frontal gyrus) following active tDCS, which was absent in the sham group. Taken together, these results suggest that anodal tDCS of the occipital cortices differentially modulates spontaneous and induced activity, and may interfere with the entrainment of neuronal populations by a visual-flicker stimulus. These findings also demonstrate the importance of electrode configuration on whole-brain dynamics, and highlight the deceptively complicated nature of tDCS in the context of neurophysiology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study

Heinrichs‐Graham

McDermott²,

Mills³

et al. 2017

Cortex

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“…These two studies are complemented by the paper from Tom Marshall and colleagues, which investigated the relationship between cortical excitability and visual oscillatory responses (Marshall et al, 2016). Like the two previous studies, Marshall and colleagues demonstrated that concurrent tDCS/MEG is a feasible tool for investigating e.g.…”

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confidence: 90%

Transcranial electric stimulation (tES) and NeuroImaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience

2016

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Transcranial electric stimulation (tES) of the brain has attracted an increased interest in recent years. Yet, despite remarkable research efforts to date, the underlying neurobiological mechanisms of tES' effects are still incompletely understood. This Special Issue aims to provide a comprehensive and up-to-date overview of the state-of-the-art in studies combining tES and neuroimaging, while introducing most recent insights and outlining future prospects related to this new and rapidly growing field. The findings reported here combine methodological advancements with insights into the underlying mechanisms of tES itself. At the same time, they also point to the many caveats and specific challenges associated with such studies, which can arise from both technical and biological sources. Besides promising to advance basic neuroscience, combined tES and neuroimaging studies may also substantially change previous conceptions about the methods of action of electric or magnetic stimulation on the brain.

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“…Although numerous studies have demonstrated that these electrical stimulation methods can effect perception (Antal et al, 2004b;Neuling et al, 2012a;Helfrich et al, 2014) and cognition (Marshall et al, 2006;Zaehle et al, 2011;Antonenko et al, 2016;Simonsmeier and Grabner, 2017), it seems that many other studies have found little to no evidence supporting the efficacy of these techniques (Brignani et al, 2013;Tremblay et al, 2014;Horvath et al, 2015;Marshall et al, 2016;Veniero et al, 2017). Therefore, here we used a well-studied paradigm of alpha oscillations affecting visual perception as a test of the feasibility of using tCS to manipulate oscillations and cognition.…”

Section: Introductionmentioning

confidence: 99%

Does 10-Hz cathodal oscillating current of the parieto-occipital lobe modulate target detection?

Sheldon

Mathewson

2017

Preprint

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The phase of alpha (8-12 Hz) brain oscillations have been associated with moment to moment changes in visual attention and awareness. Previous work has demonstrated that endogenous oscillations and subsequent behavior can be modulated by oscillating transcranial current stimulation (otCS). The purpose of the current study is to establish the efficacy of cathodal otCS for modulation of the ongoing alpha brain oscillations, allowing for modulation of individual's visual perception. Thirty-six participants performed a target detection with sham and 10-Hz cathodal otCS. Each participant had two practice and two experimental sets composed of three blocks of 128 trials per block. Stimulating electrodes were placed on the participant's head with the anode electrode at Cz and the cathode electrode at Oz. A 0.5 mA current was applied every 100 ms (10 Hz frequency) during the otCS condition. The same current and frequency was applied for the first 10-20 s of the sham condition, after which the current was turned off. Target detection rates were compared between the sham and otCS experimental conditions in order to test for effects of otCS phase on target detection. We found no significant difference in target detection rates between the sham and otCS conditions, and discuss potential reasons for the apparent inability of cathodal otCS to effectively modulate visual perception.

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On the relationship between cortical excitability and visual oscillatory responses — A concurrent tDCS–MEG study

Cited by 40 publications

References 65 publications

Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study

Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study

Transcranial electric stimulation (tES) and NeuroImaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience

Does 10-Hz cathodal oscillating current of the parieto-occipital lobe modulate target detection?

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