Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study

Heinrichs‐Graham, Elizabeth; McDermott, Timothy J.; Mills, Mackenzie S.; Coolidge, Nathan M.; Wilson, Tony W.

doi:10.1016/j.cortex.2016.11.016

Cited by 26 publications

(22 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While we did not find a significant change in spontaneous alpha for the cathodal tDCS group in the present study, this previous work supports the notion that tDCS can lead to changes in spontaneous activity. Our two previous MEG studies using tDCS, which involved roughly 50% of the same participants, also showed the same net effect in that spontaneous alpha power was significantly elevated in the anodal tDCS group (Heinrichs‐Graham, McDermott, Mills, Coolidge, & Wilson, ; Wilson, McDermott, Mills, Coolidge, & Heinrichs‐Graham, ). It is possible that anodal tDCS of the occipital cortices results in an increase in spontaneous alpha activity, which ultimately broadly impairs visual attention processes and thereby performance on the flanker and similar tasks.…”

Section: Discussionsupporting

confidence: 59%

tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention

McDermott

Wiesman

Mills

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Transcranial direct‐current stimulation (tDCS) is a noninvasive method for modulating human brain activity. Although there are several hypotheses about the net effects of tDCS on brain function, the field's understanding remains incomplete and this is especially true for neural oscillatory activity during cognitive task performance. In this study, we examined whether different polarities of occipital tDCS differentially alter flanker task performance and the underlying neural dynamics. To this end, 48 healthy adults underwent 20 min of anodal, cathodal, or sham occipital tDCS, and then completed a visual flanker task during high‐density magnetoencephalography (MEG). The resulting oscillatory responses were imaged in the time‐frequency domain using beamforming, and the effects of tDCS on task‐related oscillations and spontaneous neural activity were assessed. The results indicated that anodal tDCS of the occipital cortices inhibited flanker task performance as measured by reaction time, elevated spontaneous activity in the theta (4–7 Hz) and alpha (9–14 Hz) bands in prefrontal and occipital cortices, respectively, and reduced task‐related theta oscillatory activity in prefrontal cortices during task performance. Cathodal tDCS of the occipital cortices did not significantly affect behavior or any of these neuronal parameters in any brain region. Lastly, the power of theta oscillations in the prefrontal cortices was inversely correlated with reaction time. In conclusion, anodal tDCS modulated task‐related oscillations and spontaneous activity across multiple cortical areas, both near the electrode and in distant sites that were putatively connected to the targeted regions.

show abstract

Section: Discussionsupporting

confidence: 59%

tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention

McDermott

Wiesman

Mills

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…To control for Type 1 error, the two‐stage procedure described above (Section 2.5) was employed, with the criteria of at least 10,000 permutations and a threshold of p < .05. Of note, a similar analytical approach has been adopted in previous MEG studies of oscillatory activity (Grent‐'t‐Jong, Oostenveld, Jensen, Medendorp, & Praamstra, ; Heinrichs‐Graham, Hoburg, & Wilson, ; Heinrichs‐Graham, Kurz, Gehringer, & Wilson, ; Heinrichs‐Graham, McDermott, Mills, Coolidge, & Wilson, ; McDermott, Wiesman, Proskovec, Heinrichs‐Graham, & Wilson, ; Muthukumaraswamy et al, ). Additionally, to ensure that transient evoked responses did not contribute to conditional differences, we conducted the same virtual sensor time series analyses while subtracting out evoked activity.…”

Section: Methodsmentioning

confidence: 99%

“…activity(Grent-'t-Jong, Oostenveld, Jensen, Medendorp, & Praamstra, 2013Heinrichs-Graham, Hoburg, & Wilson, 2018;Heinrichs- Graham, Kurz, Gehringer, & Wilson, 2017a;Heinrichs-Graham, McDermott, Mills, Coolidge, & Wilson, 2017b;McDermott, Wiesman, Proskovec, Heinrichs-Graham, & Wilson, 2017; …”

mentioning

confidence: 99%

Oscillatory dynamics in the dorsal and ventral attention networks during the reorienting of attention

Proskovec

Heinrichs‐Graham

Wiesman

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

The ability to reorient attention within the visual field is central to daily functioning, and numerous fMRI studies have shown that the dorsal and ventral attention networks (DAN, VAN) are critical to such processes. However, despite the instantaneous nature of attentional shifts, the dynamics of oscillatory activity serving attentional reorientation remain poorly characterized. In this study, we utilized magnetoencephalography (MEG) and a Posner task to probe the dynamics of attentional reorienting in 29 healthy adults. MEG data were transformed into the time-frequency domain and significant oscillatory responses were imaged using a beamformer. Voxel time series were then extracted from peak voxels in the functional beamformer images. These time series were used to quantify the dynamics of attentional reorienting, and to compute dynamic functional connectivity. Our results indicated strong increases in theta and decreases in alpha and beta activity across many nodes in the DAN and VAN. Interestingly, theta responses were generally stronger during trials that required attentional reorienting relative to those that did not, while alpha and beta oscillations were more dynamic, with many regions exhibiting significantly stronger responses during non-reorienting trials initially, and the opposite pattern during later processing. Finally, stronger functional connectivity was found following target presentation (575-700 ms) between bilateral superior parietal lobules during attentional reorienting. In sum, these data show that visual attention is served by multiple cortical regions within the DAN and VAN, and that attentional reorienting processes are often associated with spectrally-specific oscillations that have largely distinct spatiotemporal dynamics.

show abstract

“…With regard to the degree of focality, studies have shown that HD-tDCS directly over the motor cortex at intensities derived from current density modelling elicits MEPs, while such predicted stimulation intensities at sites just anterior and posterior of the motor cortex do not elicit MEPs (Edwards et al 2013). Importantly, tDCS has been found to modulate behavioural performance across a variety of cognitive domains, depending on the location of stimulation, and further it differentially influences the neural oscillations essential to these processes (Hanley et al 2016;Marshall et al 2016;Heinrichs-Graham et al 2017;Wiesman et al 2018;Wilson et al 2018;McDermott et al 2019).…”

Section: Introductionmentioning

confidence: 99%

High‐definition transcranial direct current stimulation dissociates fronto‐visual theta lateralization during visual selective attention

Spooner

Eastman

Rezich

et al. 2020

The Journal of Physiology

Self Cite

View full text Add to dashboard Cite

Key points Visual attention involves discrete multispectral oscillatory responses in visual and ‘higher‐order’ prefrontal cortices. Prefrontal cortex laterality effects during visual selective attention are poorly characterized. High‐definition transcranial direct current stimulation dynamically modulated right‐lateralized fronto‐visual theta oscillations compared to those observed in left fronto‐visual pathways. Increased connectivity in right fronto‐visual networks after stimulation of the left dorsolateral prefrontal cortex resulted in faster task performance in the context of distractors. Our findings show clear laterality effects in theta oscillatory activity along prefrontal–visual cortical pathways during visual selective attention. Abstract Studies of visual attention have implicated oscillatory activity in the recognition, protection and temporal organization of attended representations in visual cortices. These studies have also shown that higher‐order regions such as the prefrontal cortex are critical to attentional processing, but far less is understood regarding prefrontal laterality differences in attention processing. To examine this, we selectively applied high‐definition transcranial direct current stimulation (HD‐tDCS) to the left or right dorsolateral prefrontal cortex (DLPFC). We predicted that HD‐tDCS of the left versus right prefrontal cortex would differentially modulate performance on a visual selective attention task, and alter the underlying oscillatory network dynamics. Our randomized crossover design included 27 healthy adults that underwent three separate sessions of HD‐tDCS (sham, left DLPFC and right DLPFC) for 20 min. Following stimulation, participants completed an attention protocol during magnetoencephalography. The resulting oscillatory dynamics were imaged using beamforming, and peak task‐related neural activity was subjected to dynamic functional connectivity analyses to evaluate the impact of stimulation site (i.e. left and right DLPFC) on neural interactions. Our results indicated that HD‐tDCS over the left DLPFC differentially modulated right fronto‐visual functional connectivity within the theta band compared to HD‐tDCS of the right DLPFC and further, specifically modulated the oscillatory response for detecting targets among an array of distractors. Importantly, these findings provide network‐specific insight into the complex oscillatory mechanisms serving visual selective attention.

show abstract

Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study

Cited by 26 publications

References 77 publications

tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention

tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention

Oscillatory dynamics in the dorsal and ventral attention networks during the reorienting of attention

High‐definition transcranial direct current stimulation dissociates fronto‐visual theta lateralization during visual selective attention

Contact Info

Product

Resources

About