On the protection by ketorolac of reperfusion-induced heart damage

Chávez, Edmundo; Tellez, Francisco Alejandro Felix; Pichardo, Julieta; Milán, Rebeca; Cuéllar, Adela; Carbajal, Karla; Cruz, David

doi:10.1016/s0742-8413(96)00058-8

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…The ischemic period lasted 5 min. This time was selected in agreement with previous reports [15,27,38]. Nevertheless, to get a better insight about the myocardial damage, experiments with 20 min of reperfusion were also performed.…”

Section: Heart Reperfusionmentioning

confidence: 98%

In hyperthyroid rats octylguanidine protects the heart from reperfusion damage

Pavón

Aranda

Garcı́a

et al. 2009

Endocr

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Hyperthyroidism sensitizes the heart for reperfusion injury. As known, mitochondrial permeability transition underlies reperfusion heart damage. This study was undertaken to explore the protective effect of octylguanidine (OG), an inhibitor of permeability transition, on hearts from hyperthyroid rats subjected to ischemia/reperfusion. Hyperthyroidism was induced by a daily injection of 2 mg T3/kg body weight for 5 days. OG was injected at a dose of 5 mg/kg body weight. It was found that the amine protects against reperfusion-induced permeability transition, i.e., mitochondria from hyperthyroid rats, treated with OG, retained accumulated Ca(2+), similarly to control mitochondria. OG maintained post reperfusion cardiac frequency in hyperthyroid rats at 429 +/- 16 in comparison to control and T3 treated rats (70 +/- 12 and 71 +/- 2, respectively). We also found that OG diminished the post reperfusion accumulation of IFNgamma from 34.3 +/- 2.5 to 18.7 +/- 1.35, IL-6 from 38.5 +/- 4.5 to 15.1 +/- 0.12, IL-1 from 16.78 +/- 0.73 to 12.19 +/- 1.54, and TNFalpha from 45.05 +/- 3.14 to 29.85 +/- 4.3 (pg/50 microg myocardial tissue). It is concluded that OG inhibits the hypersensitivity of the hyperthyroid myocardium to undergo reperfusion damage due to its inhibitory action on the permeability transition pore.

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Section: Heart Reperfusionmentioning

confidence: 98%

In hyperthyroid rats octylguanidine protects the heart from reperfusion damage

Pavón

Aranda

Garcı́a

et al. 2009

Endocr

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“…The methodology described by Manning and Hearse [17] Chávez et al [18], and Parra et al [19] was used in these experiments as follows: ( n ) = 20 male Wistar rats, weighing between 280 and 300 g, were anesthetized with sodium pentobarbital (60 mg/kg, i. p), and maintained under assisted respiration, by means of tracheotomy. Respiratory frequency was maintained at 72 ventilations per minute.…”

Section: Methodsmentioning

confidence: 99%

“…The occlusion of the artery was attained by passing a short tube over the vessel and clamping it firmly with the thread. The ischemic stage lasted 5 min, as established by Manning and Hearse [17], Chávez et al [18], and Parra et al [19]. Removing the clamp started reperfusion.…”

Section: Methodsmentioning

confidence: 99%

Lasalocid immediately and completely prevents the myocardial damage caused by coronary ischemia reperfusion in rat heart

Estrada-Orihuela¹,

Ibarra-Pérez²

2018

Mol Cell Biochem

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Lasalocid, a specific mobile membrane ionophore for calcium, dopamine and norepinephrine was assayed in its capacity to reduce or maintain unaltered the cardiovascular function in conditions of imminent myocardial injury. In experiments of coronary blockade and reperfusion carried out in rat heart, it was found that when administered from 5 to 30 minutes prior to the induction of coronary blockade, at a concentration of 2 mg/kg of body weight, the ionophore immediately, simultaneously, and completely interrupts the blood pressure decay, cardiac frequency increase, electrical ventricular tachycardia and fibrillation, as well as the fall of mitochondrial oxidative phosphorylation and decay of mitochondrial oxygen uptake provoked by the induced myocardial injury. It appears that the molecular mode of action of the lasalocid is associated with its unique ability to transport both calcium and the catecholamines, dopamine and norepinephrine, across mitochondrial and bimolecular lipid membranes, as well as through synaptic cell membrane terminals from rat heart, myocardial fibers of the heart and heart chromaffin membrane vesicles. It is suggested that for the potential medical use of lasalocid to detain incoming ischemic myocardial damage, there exists a need to develop a personal electronic device able to simultaneously monitor, detect, and inform on the very early and simultaneous signs of cardiac alterations of electrical, mechano-chemical, metabolic and hydraulic nature, all which precede heart failure and to administer the lasalocid.

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“…The Coxibs may be a safer alternative, but avoidance of hypersensitivity in those allergic to NSAIDs is not guaranteed. 21 NSAIDs increase the risk for heart failure and are therefore contraindicated in this condition and should be used with caution in patients taking angiotensin-converting enzyme inhibitors due to a potential risk for interaction. NSAIDs affect platelet function negatively and may therefore cause impaired hemostasis.…”

Section: Side Effects and Contraindicationsmentioning

confidence: 99%

Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Cyclooxygenase-2 Selective Inhibitors

Gupta

Jakobsson

2014

Plastic and Reconstructive Surgery

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Plastic and cosmetic surgery is often performed as an ambulatory procedure, and pain is often mild to moderate. Good pain relief is central to patient comfort and satisfaction. Analgesics used should ensure rapid onset and adequate pain relief lasting a sufficiently long duration with minimal or no side effects. Acetaminophen is well tolerated by patients, efficacious, and associated with only minor side effects, when used in the minimal effective doses. Nonsteroidal anti-inflammatory drugs (NSAIDs) are more efficacious, having lower numbers needed to treat compared with acetaminophen, but have several side effects and contraindications. However, when used in the correct doses in healthy patients, NSAIDs are excellent for pain management with one caveat that there is an increased risk for oozing or bleeding. In contrast, cyclooxygenase inhibitors (Coxibs) are equally efficacious as NSAIDs but have the added advantage that they have minimal or no effect on platelet function, and therefore, the risk for bleeding complications is minimal. However, there has been some concern about the risk of vascular events in patients with ischemic heart disease, specifically when using Coxibs, but even some NSAIDs, for example, diclofenac. In conclusion, acetaminophen should be given postoperatively to all patients undergoing plastic surgical procedures. For patients undergoing moderately invasive surgery, the addition of Coxibs to acetaminophen would be an advantage except in the patient with ischemic heart disease where NSAIDs could have a place in management of pain. Side effects and contraindications of NSAIDs, however, restrict their use to the healthy patient with mild comorbidities.

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On the protection by ketorolac of reperfusion-induced heart damage

Cited by 5 publications

References 28 publications

In hyperthyroid rats octylguanidine protects the heart from reperfusion damage

In hyperthyroid rats octylguanidine protects the heart from reperfusion damage

Lasalocid immediately and completely prevents the myocardial damage caused by coronary ischemia reperfusion in rat heart

Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Cyclooxygenase-2 Selective Inhibitors

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