On the potential of Tephrosia purpurea as anti-Helicobacter pylori agent

Chinniah, Annalakshmi; Mohapatra, Satyabrata; Goswami, Suchandra; Mahapatra, Anita; Kar, Sudip K.; Mallavadhani, Uppuluri Venkata; Das, Priya

doi:10.1016/j.jep.2009.05.016

Cited by 21 publications

(11 citation statements)

References 13 publications

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“…In another study, Terminalia macroptera root hydroethanol extract showed inhibitory effects on 92% of tested H. pylori strains (three reference strains and 62 clinical isolates) with the inhibitory concentration range of 25 to 200 μg/mL, and 20% of the clinical strains were found resistant to at least two of three antibiotics (clarithromycin, ciprofloxacin, and metronidazole) in multitherapy of H. pylori infections (Silva et al, 2012). Moreover, methanol extract and less polar fractions (n-hexane and chloroform fractions) of Tephrosia purpurea remained active in an acidic condition like the stomach environment, and showed notable inhibitory effects on H. pylori in vitro, even on metronidazole-resistant strains (Chinniah et al, 2009).…”

Section: Anti-h Pylori Activitymentioning

confidence: 99%

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Liu

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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Helicobacter pylori is the main pathogen that induces chronic gastritis, peptic ulcers, atrophic gastritis, and other gastric disorders, and it is classified as a group I carcinogen. To eradicate H. pylori infection, triple therapy consisting of two antibiotics and a proton pump inhibitor is the most widely recommended first-line therapeutic strategy. Antimicrobial resistance to antibiotics contained in triple therapy could lead to therapeutic regimen failures. Recent studies showed that many natural products, including fruits, vegetables, spices, and medicinal plants, possess inhibitory effects on H. pylori, indicating their potential to be alternatives to prevent and manage H. pylori infection. This review summarizes the effects of natural products on H. pylori infection and highlights the mechanisms of action.

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Section: Anti-h Pylori Activitymentioning

confidence: 99%

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Liu

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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“…The taxon T. purpurea is among the most widely used Tephrosia species in traditional medicine (Damre et al, 2003). Various biological activities including antibacterial (Hegazy et al, 2009;Chinniah et al, 2009), antidiabetic and antioxidant (Pavana et al, 2009), immunomodulatory (Damre et al, 2003), anti-inflammatory (Damre et al, 2003) and cancer chemopreventive activities (Chang et al, 2000) have been reported for extracts and pure compounds from this plant. T. purpurea.…”

Section: Introductionmentioning

confidence: 99%

Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea

Juma

Akala

Eyase

et al. 2011

Phytochemistry Letters

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“…There is evidence of pharmacological activity of extracts obtained from plants of Tephosia genus including toxic and lavicidal effects (Arriaga et al, 2009a;Lapointe et al, 2003), antifungal (Vijayan et al, 2008), anti-Helicobacter pylori (Chinniah et al, 2009), wound healing potential (Lodhi et al, 2006), hepatoprotective against thioacetamide-induced hepatotoxicity (Khatri et al, 2009), antihyperglycemic and antihyperlipidemic in streptozotocin induced diabetic rats (Pavana et al, 2007), alleviates phorbol ester-induced tumor promotion response in murine skin , ameliorates N-diethylnitrosamine and potassium bromate-mediated renal oxidative stress and toxicity in rats (Khan et al, 2001), reduction in the severity of lithium-pilocarpine induced status epilepticus (Asuntha et al, 2010) and a flavonoidal fraction of T. purpurea inhibits sheep red blood cells-induced delayed-type hypersensitivity reactions (Damre et al, 2003). Thus, there are some pharmacological studies on the Tephosia genus activities.…”

Section: Discussionmentioning

confidence: 99%

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

Martínez

Zarpelon

Zimermann

et al. 2012

Rev. bras. farmacogn.

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Abstract:Tephrosia toxicaria (Sw.) Pers., which is currently known as T. sinapou (Buc'hoz) A. Chev., Fabaceae, is a source of compounds such as fl avonoids, however, few studies addressed the anti-infl ammatory and antioxidant effects of T. sinapou. Therefore, we evaluated the antioxidant mechanisms of the T. sinapou ethyl acetate extract in vitro, and whether the extract affects leukocyte recruitment in four models of infl ammation and the involvement of nitric oxide and cytokines in its mechanism. In vitro, it was observed that the extract presented hydrogen donating ability to 2,2-diphenyl-1-picryl-hydrazyl radical (DPPH • ), 2,2'-azino-di-(3-ethylbenzthiazoline-6-sulphonic acid) radical (ABTS + ), and also effi ciently inhibited iron-dependent and independent lipid peroxidation and iron chelation assays. In vivo, it inhibited the recruitment of total leukocytes and neutrophil induced by carrageenin, zymosan, glycogen and lipopolysaccharide in the peritoneal cavity of mice. Two mechanisms were detected: 1) T. sinapou effect on leukocyte recruitment depends on nitric oxide since was dose-dependently inhibited by treatment with L-NAME (nitric oxide synthase inhibitor), and 2) the extract also inhibited the production of crucial cytokines for the leukocyte recruitment; tumor necrosis factor α and interleukin-1β. Concluding, T. sinapou ethyl acetate extract reduces oxidative stress in vitro, and infl ammatory leukocyte recruitment by a mechanism related to inhibition of cytokine production, and in a nitric oxide dependent manner in vivo.

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On the potential of Tephrosia purpurea as anti-Helicobacter pylori agent

Cited by 21 publications

References 13 publications

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

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