On the positional reactivity order in the sulfonation of phenyl‐and naphthyl‐substituted naphthalenes with SO₃

Abstract

Abstract. The sulfonation of 1-and 2-phenylnaphthalene,

Sulfonated naphthyl porphyrins as agents against HIV-1

“…Work of Cerfontain and colleagues [40] has shown that the model compound 1,1 0 -binaphthalene sulfonates initially at the 4-position, followed by sulfonation at the 4 0 -position, and then with almost equal facility at the 6-or 7-position. Six equivalents of SO 3 (in CH 2 Cl 2 at 22°C, 40 min) gives only about 10% of the species with one sulfonic acid on each ring; all the rest of the material has two sulfonic acids on at least one ring.…”

“…Six equivalents of SO 3 (in CH 2 Cl 2 at 22°C, 40 min) gives only about 10% of the species with one sulfonic acid on each ring; all the rest of the material has two sulfonic acids on at least one ring. 2,2 0 -Binaphthalene sulfonates initially at the 8-position, followed by sulfonation at the 8 0 -position [40]. The subsequent sulfonic acids are added at the 6-or 4-positions.…”

A simple and efficient synthesis protocol for sulfonation of nitrobenzene under solvent-free conditions via a microreactor

“…Other literature results in the batch mode were also summarized in Table 3 (entries 1-3). [32][33][34] Entry 1 shows that only 50% yield was achieved in a long reaction time of 72 h. In addition, 2.l mol trifluoroacetic anhydride (TFFA) should be used as a catalyst per mol NB. Entry 2 demonstrates that an excellent yield of 98% was obtained at room temperature, but much more dichloroethane was used as a solvent, and the total ratio of (SO 3 + H 2 SO 4 ) to NB was as high as two.…”