Experimental Hematology Today 1978 1978
DOI: 10.1007/978-1-4612-6304-3_16
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On the Pathogenesis and Treatment of Aplastic Anemia

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1978
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Cited by 10 publications
(10 citation statements)
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“…First, our re sults, both with bolus methylprednisolone [2] and with ALG, confirm Speck's conten tion [15] that SAA is not uniformly a defect of the earliest hemopoietic progenitor cell, and that, at least in some cases, it may be an autoimmune condition not so distant from pure red cell anemia (PRCA), depending on the cellular target (stem cell in SAA, an un identified erythroid precursor in PRCA) against which the immunologic reaction is mounted [7,8].…”
Section: Discussionsupporting
confidence: 74%
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“…First, our re sults, both with bolus methylprednisolone [2] and with ALG, confirm Speck's conten tion [15] that SAA is not uniformly a defect of the earliest hemopoietic progenitor cell, and that, at least in some cases, it may be an autoimmune condition not so distant from pure red cell anemia (PRCA), depending on the cellular target (stem cell in SAA, an un identified erythroid precursor in PRCA) against which the immunologic reaction is mounted [7,8].…”
Section: Discussionsupporting
confidence: 74%
“…In our patients mar row reconstitutions were clearly autologous as proved by means of chromosome studies and red cell phenotypes. The reversal to normal blood and marrow parameters in 3 cases, as in a recent much larger series [15] would suggest that engraftment is not a prerequisite to ensure long-term survival as previously reported [11].…”
Section: Discussionmentioning
confidence: 62%
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“…A possible in vivo correlate of our find ing is the demonstration that in mice the BM microenvironment is affected by ben zene poisoning [2], while the stem cells are spared [2,13]. They may also offer an ex planation of earlier data by Speck et al [14], who found that benzene-treated aplas tic rabbits can be cured by administration of a combination of antilymphocyte serum and allogeneic BM.…”
Section: Discussionsupporting
confidence: 56%
“…The results of marrow grafts between HLA-non-fully-identical siblings continue to be frustrating in SAA [59], In 1977 we reported the results of 29 patients with SAA without HLA-identical siblings treat ed with antilymphocyte globulin (ALG) with or without marrow infusion [60], The rationale and the experimental and clini cal bases for this therapeutic approach have been outlined [61][62][63]. In 1981 we published the results of 50 patients with SAA treated and evaluated in a prospec tive study according to one protocol com paring BMT with ALG treatment aiming at autologous hemopoietic reconstitution [64], This study showed that therapy with ALG is at least as good or better than BMT.…”
Section: Severe Aplastic Anemiamentioning
confidence: 99%