1982
DOI: 10.1159/000207021
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Inhibition of CFU<sub>E</sub> and BFU<sub>E</sub> by Mononuclear Peripheral Blood Cells during Chronic Benzene Treatment in Rabbits

Abstract: Peripheral blood cells from untransfused rabbits that were treated with a moderate dose of benzene during 2 months were cocultivated with autologous and normal bone marrow. In a significant number of experiments, CFUE and BFUE growth of both autologous and normal bone marrow was suppressed. Further experiments showed that this inhibition was associated with adherent mononuclear peripheral blood cells. It is concluded that benzene, an established myelotoxic agent, also induces CFUE Show more

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Cited by 7 publications
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“…It is known that immunologically competent cells play a role in erythroblast differentiation and proliferation [20]. Immunologically competent cells have also been reported to effect secondary anemia, for instance, in the suppression of marrow cell maturation with development of adjuvant arthritis in rats [21] and in the inhibition of CFU-e-derived colony formation by peripheral blood lymphocytes of rabbits treated with benzene [22,23]. We also investigated the effects of immunologically competent cells of these patients on the formation of colonies from the bone marrow CFU-e of human control subjects.…”
Section: Ra Patients Harvey Et A1mentioning
confidence: 99%
“…It is known that immunologically competent cells play a role in erythroblast differentiation and proliferation [20]. Immunologically competent cells have also been reported to effect secondary anemia, for instance, in the suppression of marrow cell maturation with development of adjuvant arthritis in rats [21] and in the inhibition of CFU-e-derived colony formation by peripheral blood lymphocytes of rabbits treated with benzene [22,23]. We also investigated the effects of immunologically competent cells of these patients on the formation of colonies from the bone marrow CFU-e of human control subjects.…”
Section: Ra Patients Harvey Et A1mentioning
confidence: 99%