Inhibition of CFU&lt;sub&gt;E&lt;/sub&gt; and BFU&lt;sub&gt;E&lt;/sub&gt; by Mononuclear Peripheral Blood Cells during Chronic Benzene Treatment in Rabbits

Haak, H. L.; Speck, B

doi:10.1159/000207021

Cited by 7 publications

(1 citation statement)

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“…It is known that immunologically competent cells play a role in erythroblast differentiation and proliferation [20]. Immunologically competent cells have also been reported to effect secondary anemia, for instance, in the suppression of marrow cell maturation with development of adjuvant arthritis in rats [21] and in the inhibition of CFU-e-derived colony formation by peripheral blood lymphocytes of rabbits treated with benzene [22,23]. We also investigated the effects of immunologically competent cells of these patients on the formation of colonies from the bone marrow CFU-e of human control subjects.…”

Section: Ra Patients Harvey Et A1mentioning

confidence: 99%

Immunological aspects of the anemia of rheumatoid arthritis

et al. 1987

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In order to investigate the cause of the anemia concomitant with rheumatoid arthritis (RA), we examined, using the erythroid colony assay of human bone marrow colony-forming units-erythroid (CFU-e) and burst-forming units-erythroid (BFU-e), the effects of the patients' serum and peripheral blood T lymphocytes on the CFU-e-derived colonies. The counts of erythroid colonies of RA patients were markedly lower than those of human control subjects [CFU-e: control 152.9 +/- 30.6 (n = 19), RA 51.1 +/- 13.6 (n = 7), t = 7.66567, p less than 0.01; BFU-e: control 25.2 +/- 5.9 (n = 5), RA 12.6 +/- 2.6 (n = 7), t = 4.574, p less than 0.01]. The serum from two out of seven RA patients slightly inhibited the formation of CFU-e-derived colonies of human control subjects (t = 2.31, 0.05 less than p less than 0.1); however, the serum from the other five RA patients did not significantly inhibit human control erythroid colony formation as compared with human control serum (t = 0.981, 0.3 less than p less than 0.4). On the other hand, peripheral blood T lymphocytes of the patients markedly inhibited the formation of CFU-e-derived colonies of the control subjects as compared with peripheral blood T lymphocytes from human control subjects (t = 4.24, p less than 0.01). The above-mentioned results suggest that the peripheral blood T lymphocytes of RA patients might play a role as one of the causes of the concomitant anemia of RA patients.

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Section: Ra Patients Harvey Et A1mentioning

confidence: 99%

Immunological aspects of the anemia of rheumatoid arthritis

et al. 1987

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The effects of benzene inhalation on murine hematopoietic precursor cells (CFU‐e, BFU‐e and CFU‐gm)

Hilderbrand

Murphy

1983

The International Journal of Cell Cloning

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Male B6D2F1 mice were exposed by inhalation to 4000 ppm of benzene for 8 h/day for 1, 2, 3, 5, 7 or 14 days and then sacrificed at 18 h following the last exposure. The cellularities of both femur and spleen were depressed for the duration of benzene exposure. BFU-e/femur declined for 3 days, rebounded to control levels by day 5, and were again depressed by day 7. CFU-e/femur were initially depressed, but by day 7, the concentrations of CFU-e were so elevated that the total number had actually rebounded to slightly higher than control values. CFU-gm/femur remained depressed for the duration of the exposure periods. CFU-e, BFU-e and CFU-gm/spleen were depressed following all exposures. The toxic effects of benzene on hematopoiesis that are immediate are not ascribable to migration of stem cells between femur and spleen. The depressive effects of benzene inhalation on erythropoiesis may be compensated by the rapid proliferation of CFU-e.

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