Immunological aspects of the anemia of rheumatoid arthritis

Sugimoto, Masakuni; Wakabayashi, Y; Hirose, Shunichi; Takaku, Fumimaro

doi:10.1002/ajh.2830250102

Cited by 16 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To establish this one could add serum from anemic RA patients with and without anti-TNFcr to bone marrow cultures. However, in our experience which is shared by others [42] the results of serum addition to marrow cultures are variable and inconsistent probably due to the presence of other undefined endotoxines and lipopolysaccharides, whereas, as discussed previously, serum TNFcr concentrations may be lower than necessary for in uitro suppression.…”

Section: Values Indicate Numbers Of Bfue Per Lo5 Cells (Median; Rangementioning

confidence: 44%

Tumor necrosis factor alpha is associated with disease activity and the degree of anemia in patients with rheumatoid arthritis

Vreugdenhil

Löwenberg

Eijk

et al. 1992

Eur J Clin Investigation

View full text Add to dashboard Cite

To elucidate the role of tumor necrosis factor alpha (TNF) in determining anemia of chronic disease (ACD) in rheumatoid arthritis (RA), 24 patients were studied for disease parameters, TNF serum levels and bone marrow for erythroid colony growth and compared with six controls. Serum TNF alpha was highest in ACD and correlated well with RA disease parameters. Both TNF and other RA disease parameters correlated inversely with degree of anemia. BFUe counts were lower in ACD, correlated positively with Hb and negatively with erythrocyte sedimentation rate (ESR). TNF reduced whereas anti-TNF upregulated in vitro erythroid colony counts. TNF production occurred in similar amounts in bone marrow cultures in the three groups. From these preliminary findings we conclude that ACD in RA correlates with by RA disease activity and that TNF may serve not only as an RA disease marker but also could be one of the factors mediating impaired erythropoiesis in ACD in active RA.

show abstract

Section: Values Indicate Numbers Of Bfue Per Lo5 Cells (Median; Rangementioning

confidence: 44%

Tumor necrosis factor alpha is associated with disease activity and the degree of anemia in patients with rheumatoid arthritis

Vreugdenhil

Löwenberg

Eijk

et al. 1992

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Other studies have also implicated T-lymphocytes as inhibitors of erythropoiesis in chronic inflammatory disorders. Sugimoto et al (1989) reported that T-lymphocytes from anemic patients with rheumatoid arthritis inhibited the growth in vitro of normal CFU-E relative to T-lymphocytes from normal subjects.…”

Section: Discuss I 0 Nmentioning

confidence: 91%

“…Sugimoto et al (1989) reported that T-lymphocytes from anemic patients with rheumatoid arthritis inhibited the growth in vitro of normal CFU-E relative to T-lymphocytes from normal subjects.…”

Section: Discuss I 0 Nmentioning

confidence: 98%

Inhibition of human erythroid colony‐forming units by interleukin‐1 is mediated by gamma interferon

Means

Dessypris

Krantz

1992

Journal Cellular Physiology

135

View full text Add to dashboard Cite

IL-1 inhibits erythropoiesis in vivo and in vitro. This inhibition was studied by comparing the effect of recombinant human IL-1 (rhIL-1) on highly purified CFU-erythroid (E) generated from peripheral blood burst-forming units-erythroid (BFU-E) (mean purity 44.4%) with its effect on unpurified marrow CFU-E (mean purity 0.36%). Colony formation by marrow CFU-E was significantly inhibited by rhIL-1, while colony formation by highly purified CFU-E was not inhibited. However, purified CFU-E colonies were inhibited by rhIL-1 in the presence of autologous T-lymphocytes, and also by cell-free conditioned medium prepared from T-lymphocytes stimulated by rhIL-1. This inhibitory effect was ablated by neutralizing antibodies to gamma interferon (IFN), but not by antibodies to human IL-1, tumor necrosis factor, or beta IFN. Colony formation by highly purified CFU-E was also inhibited by recombinant human gamma IFN (rh gamma IFN). IL-1 and gamma IFN play significant roles in the pathogenesis of the anemia of chronic disease. These studies indicate that rhIL-1 inhibits CFU-E colony formation by an indirect mechanism involving T-lymphocytes and requiring gamma IFN and that gamma IFN itself is most probably the direct mediator of this effect.

show abstract

“…Cells derived from the bone marrow of RA patients showed less effective colony formation potency when compared to HC-derived bone marrow cells [191-193]. Further studies confirmed the reduced proliferative capacity of CD34+ HSC from RA patients [194-198].…”

Section: The Nine Hallmarks Of Aging and Ramentioning

confidence: 99%

Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging

Chalan¹,

Berg²,

Kroesen

et al. 2015

CAS

View full text Add to dashboard Cite

Age is the most important risk factor for the development of infectious diseases, cancer and chronic inflammatory diseases including rheumatoid arthritis (RA). The very act of living causes damage to cells. A network of molecular, cellular and physiological maintenance and repair systems creates a buffering capacity against these damages. Aging leads to progressive shrinkage of the buffering capacity and increases vulnerability. In order to better understand the complex mammalian aging processes, nine hallmarks of aging and their interrelatedness were recently put forward.RA is a chronic autoimmune disease affecting the joints. Although RA may develop at a young age, the incidence of RA increases with age. It has been suggested that RA may develop as a consequence of premature aging (immunosenescence) of the immune system. Alternatively, premature aging may be the consequence of the inflammatory state in RA. In an effort to answer this chicken and egg conundrum, we here outline and discuss the nine hallmarks of aging, their contribution to the pre-aged phenotype and the effects of treatment on the reversibility of immunosenescence in RA.

show abstract

Immunological aspects of the anemia of rheumatoid arthritis

Cited by 16 publications

References 20 publications

Tumor necrosis factor alpha is associated with disease activity and the degree of anemia in patients with rheumatoid arthritis

Tumor necrosis factor alpha is associated with disease activity and the degree of anemia in patients with rheumatoid arthritis

Inhibition of human erythroid colony‐forming units by interleukin‐1 is mediated by gamma interferon

Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging

Contact Info

Product

Resources

About