On the Limits of High-Speed Microthermal Focusing Field-Flow Fractionation

The behavior of microparticles exposed to gravitational and lift forces and to the velocity gradient in flow velocity profile formed in microfluidic conduits is studied from the viewpoint of the transient period (the relaxation) between the moment at which a particle starts to be transported by the hydrodynamic flow and the time at which it reaches an equilibrium position, characterized by a balance of all active forces. The theoretical model allowing the calculation of the relaxation time is proposed. The numerical calculus based on the proposed model is compared with the experimental data obtained under different experimental conditions, namely, for different lengths of microfluidic channels, different average linear velocities of the carrier liquid, and different sizes and densities of the particles used in the study. The results are important for the optimization of microfluidic separation units such as microthermal field-flow fractionation channels in which the separation or manipulation of the microparticles of various origin, synthetic, natural, biological, etc., is performed under similar experimental conditions but by applying an additional thermodynamic force.

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Relaxation of microparticles exposed to hydrodynamic forces in microfluidic conduits

Janča

Halabalová

Polášek

et al. 2010

Anal Bioanal Chem

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Fractionation and characterization of nano- and microparticles in liquid media

et al. 2011

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Submicron and micron particles present in liquid environmental, biological, and technological samples differ in their dimensions, shape, mass, chemical composition, and charge. Their properties cannot be reliably studied unless the particles are fractionated. Synthetic particles applied as components of analytical systems may also need preliminary fractionation and investigation. The review is focused on the methods for fractionation and characterization of nanoparticles and microparticles in liquid media, the most representative examples of their application, and the trends in developing novel approaches to the separation and investigation of particles. Among the separation techniques, the main attention is devoted to membrane filtration, field-flow fractionation, chromatographic, and capillary electrokinetic methods. Microfluidic systems employing the above-mentioned and other separation principles and providing a basis for the fabrication of lab-on-chip devices are also examined. Laser light scattering methods and other physical techniques for the characterization of particles are considered. Special attention is given to "hyphenated" techniques which enable the separation and characterization of particles to be performed in online modes.

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On the Focusing Mechanism in Thermal Field-Flow Fractionation of Macromolecules

Janča

2024

Chromatographia

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On the Limits of High-Speed Microthermal Focusing Field-Flow Fractionation

Cited by 4 publications

References 12 publications

Relaxation of microparticles exposed to hydrodynamic forces in microfluidic conduits

Relaxation of microparticles exposed to hydrodynamic forces in microfluidic conduits

Fractionation and characterization of nano- and microparticles in liquid media

On the Focusing Mechanism in Thermal Field-Flow Fractionation of Macromolecules

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