On the incorporation of Rhodamine B and 2′,7′-dichlorofluorescein dyes in silica: Synthesis of fluorescent nanoparticles

Gomes, Eymeric; Carvalho, Idalina M.M. de; Diógenes, Izaura C.N.; Sousa, Eduardo Henrique Silva; Longhinotti, Elisane

doi:10.1016/j.optmat.2014.02.028

Cited by 13 publications

(6 citation statements)

References 41 publications

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“…Nanoparticles based on many diverse materials have been synthesized and employed as host matrixes for drug releasers, among which we can mention metallic and magnetic nanoparticles, − metal–organic structures (MOFs), Prussian blue-based nanoparticles, , including others. Additionally, surface functionalization with specific molecules such as folic acid, , proteins, antibodies, and others, can provide some interesting advantage to these nanomaterials by delivering drugs to a specific target. This process can increase drug efficiency, while it should reduce toxic responses.…”

Section: Nanoparticles In Drug Deliverymentioning

confidence: 99%

Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles

et al. 2022

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For more than 70 years, sodium nitroprusside (SNP) has been used to treat severe hypertension in hospital emergency settings. During this time, a few other clinical uses have also emerged such as in the treatment of acute heart failure as well as improving mitral incompetence and in the intra-and perioperative management during heart surgery. This drug functions by releasing nitric oxide (NO), which modulates several biological processes with many potential therapeutic applications. However, this small molecule has a short lifetime, and it has been administered through the use of NO donor molecules such as SNP. On the other hand, SNP also has some setbacks such as the release of cyanide ions, high water solubility, and very fast NO release kinetics. Currently, there are many drug delivery strategies that can be applied to overcome many of these limitations, providing novel opportunities for the use of old drugs, including SNP. This Perspective describes some nitroprusside properties and highlights new potential therapeutic uses arising from the use of drug delivery systems, mainly silica-based nanoparticles. There is a series of great opportunities to further explore SNP in many medical issues as reviewed, which deserves a closer look by the scientific community.

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Section: Nanoparticles In Drug Deliverymentioning

confidence: 99%

Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles

et al. 2022

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“…To date, dye-doped SiNPs are mainly prepared by three methods: the covalent coupling method, the electrostatic adsorption method based on the Stöber system [ 21 , 22 , 23 , 24 ], and the reverse microemulsion method [ 25 , 26 , 27 ]. The reverse microemulsion system is a water/oil type microemulsion, which is composed of an oil-continuous phase, a water-dispersed phase, a surfactant and a cosurfactant.…”

Section: Introductionmentioning

confidence: 99%

Preparation of 1, 3, 6, 8-Pyrenesulfonic Acid Tetrasodium Salt Dye-Doped Silica Nanoparticles and Their Application in Water-Based Anti-Counterfeit Ink

Jiao

Zhang

2020

Materials

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In order to improve the luminescent stability of water-based anti-counterfeit ink, a new fluorescent material is prepared by doping dye into silica nanoparticles. Water soluble anionic dye 1, 3, 6, 8-pyrenesulfonic acid sodium salt (PTSA) is selected as the dopant. In this work, PTSA is successfully trapped into silica nanoparticles (SiNPs) by the reverse microemulsion method using cationic polyelectrolyte poly (dimethyl diallyl ammonium chloride; PDADMAC) as a bridge. The UV absorption spectra, fluorescence emission spectra and fluorescent decay curves are used to describe the luminescent properties of the PTSA-doped silica nanoparticles (PTSA-SiNPs). In addition, the as-prepared PTSA-SiNPs and polyurethane waterborne emulsion are used to prepare water-based anti-counterfeit ink, and fluorescent patterns are successfully printed through screen-printing. The samples printed by the ink exhibit desirable fluorescence properties, heat stability, robust photostability, and a fluorescent anti-counterfeit effect, which makes the PTSA-SiNPs promising luminescent materials for anti-counterfeit applications.

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“…There are several reports on FRET in dye-silica nanoconjugates using various FRET pairs [40], but not many of these discuss the excited state dynamics in any detail [41,42]. The FRET pair used in the present study consists of Fluorescein as donor, D and Rhodamine B as acceptor, A (figure 1) [43,44]. This pair has a value of overlap integral, J = 4.5 × 10 15 M −1 cm −1 nm 4 and critical radius, R 0 = 61 Å in silica as we have determined.…”

Section: Introductionmentioning

confidence: 99%

Shape, size and composition dependence of efficiency and dynamics of Förster resonance energy transfer in dye-silica nanoconjugates

Dhir

Datta

2016

Methods Appl. Fluoresc.

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The role of relative concentrations of energy donors (fluorescein, D), acceptors (rhodamine, A) and silica on Förster resonance energy transfer (FRET) efficiency and dynamics in dye silica conjugates has been studied, as a part of our initial attempts to ascertain the potential of dye-silica nanoconjugates as light harvesting nanoantennae. Two types of dye-silica nanoconjugates, prepared by the co-condensation method, have been examined. The first is based on silica nanoshells (SNS-dye) while the second is based on silica nanoparticles (SNP-dye). Both these nanostructures have a diameter of approximately 25 nm. Efficient energy transfer (91% and 97%, respectively) has been observed in both, for total fluorophore concentration upto 5-6 mmol, irrespective of the D : A ratio. The lower efficiency at dye concentrations greater than these has been rationalized by the competitive self-quenching of D. A risetime of approximately 500 fs is observed in the A emission in SNS-dye, but there is no such feature in SNP-dye. The shape and size dependence of the FRET efficiency and dynamics has been rationalized as follows: the initial step of dye rich core formation in nanoparticles results in high proximity of dye molecules to each other, leading to highly efficient FRET than in nanoshells. In larger SNP-dye nanoconjugates of 65 nm in diameter, the FRET efficiency decreases to 85%, while a risetime in D emission emerges. This provides support to the proposed correlation between efficiency and packing. Hence, it is inferred that total fluorophore concentration, rather than D : A ratios, governs the FRET dynamics and efficiency in these systems.

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On the incorporation of Rhodamine B and 2′,7′-dichlorofluorescein dyes in silica: Synthesis of fluorescent nanoparticles

Cited by 13 publications

References 41 publications

Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles

Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles

Preparation of 1, 3, 6, 8-Pyrenesulfonic Acid Tetrasodium Salt Dye-Doped Silica Nanoparticles and Their Application in Water-Based Anti-Counterfeit Ink

Shape, size and composition dependence of efficiency and dynamics of Förster resonance energy transfer in dye-silica nanoconjugates

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