On the Hydrodynamic Instability of Hemoglobin Solutions

Přistoupil, T.I.; Marík, T

doi:10.3109/10731199009117300

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Sterilization is usually achieved by filtration or pasteurization in the carbonmonoxyHb form. Denaturation was also observed when Hb solutions were agitated while exposed to an air−liquid interface …”

Section: Hemoglobin Purificationmentioning

confidence: 99%

“…Denaturation was also observed when Hb solutions were agitated while exposed to an air-liquid interface. 563 Long-term storage of Hb is made difficult due to autoxidation. MetHb formation has been slowed by reducing temperature, controlling pH (metHb forms less rapidly above pH 7.0), increasing concentration, and addition of ascorbic acid and deferoxamine.…”

Section: Hemoglobin Purificationmentioning

confidence: 99%

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Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

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Pharmaceutical Corporation in San Diego; however, the opinion expressed here are solely his and not necessarily those of the Corporation. Jean G. Riess received his chemical engineer and doctorat-e `s-sciences degrees (the latter with Professor Guy Ourisson in 1963) from the University of Strasbourg. He then spent two years with John Van Wazer at Monsanto in Saint-Louis, MO, learning some phosphorus and transitionmetal chemistry. In 1968 he became Professor at the University of Nice, France, where he founded, directed, and eventually became honorary director of the Unite ´de Chimie Mole ´culaire (associated with the Centre National de la Recherche Scientifique). His research successively involved phosphorus chemistry, transition-metal chemistry, organometallics, and eventually perfluorochemicals. His present interests are in fluorocarbons, fluorinated amphiphiles, and their colloid chemistry, including fluorocarbon emulsions for in vivo O 2 delivery, fluorinated self-assemblies, and drug delivery systems. Professor Riess has published about 360 papers and holds ca. 25 patents. He has served on numerous councils and committees and has chaired or co-chaired international conferences on phosphorus chemistry and blood substitutes. He has won awards from the French Academy of Sciences, French Chemical Society, Alexander von Humboldt Stifftung, City of Nice and Controlled Release Society, as well as Alliance's first Distinguished Contribution Award. He holds an honorary Research Associate position at the University of California at San Diego and sits on the Board of Directors of Alliance Pharmaceutical Corp.

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Section: Hemoglobin Purificationmentioning

confidence: 99%

Section: Hemoglobin Purificationmentioning

confidence: 99%

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

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“…The reductase system generates NADPH, an oxygen-linked cofactor (14), as a reaction product, and its concentration depends on the turnover of the reducing system, adding another variable to the reaction. In addition to being slow, gas-exchange experiments promote protein denaturation at the gas-liquid interface (15). In any case, when single-wavelength analysis is used, neither methemoglobin formation nor protein denaturation during the reaction can be quantified during the reaction process.…”

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confidence: 99%