On the heterogeneity of HLA association in juvenile rheumatoid arthritis

Schiavetti, L; Galeazzi, Mauro; Tuzi, T

doi:10.1002/art.1780240923

Cited by 3 publications

(3 citation statements)

References 2 publications

(1 reference statement)

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“…Positive HLA-B27 values were found in 32%) of the present patients, which lies at the upper limit of the range 16-32% reported earlier (11,12,14,23,28,31,40). The figure of 47% of boys agrees well with GERSCHWIN et al (11), but the present number of girls, 29%, is larger.…”

Section: Discussionsupporting

confidence: 59%

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Mandibular condyle lesions related to age at onset and subtypes of juvenile rheumatoid arthritis in 15‐year‐old children

Karhulahti

Ylijoki

Rönning

1993

European J Oral Sciences

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The severity of lesions in the temporomandibular joint (TMJ) area and their association with age at onset, the various forms of juvenile rheumatoid arthritis (JRA), and certain serologic tests for rheumatoid factor (RF), antinuclear antibodies (ANA), and human leukocyte antigen (HLA)‐B27 were determined in 15‐yr‐old children. The series comprised 121 JRA children, 78 girls and 43 boys, in whom an analysis had recently been made of the relation of TMJ lesions to jaw movement and occlusal status. The mean age at onset was 7.3 yr, the girls contracting JRA earlier than the boys. Also, the girls with lesions in the TMJ area were significantly younger than those with no lesions. TMJ abnormalities were found in 50% of cases with a pauciarticular or systemic onset, but in 72% of those representing the polyarticular subtype. Flattened condyles and grave lesions were equally represented in all subgroups and in both sexes. A crossover from onset type to present diagnosis was found in 30% of the cases, mostly from pauciarticular to polyarthritis, which also increased the risk of TMJ lesions from 50 to 60%. RF, ANA, or HLA‐B27 alone did not seem to be associated with a risk of TMJ abnormalities. Maximal opening capacity is more restricted in patients with early onset or a polyarticular mode of JRA. Since the TMJ is affected in more than half of JRA children, regular measurements of maximal movements of the mandible or roentgenologic examinations of the TMJ are essential for their optimal treatment.

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Section: Discussionsupporting

confidence: 59%

“…It has been concluded on a number of occasions (2,8,(10)(11)(12)(13)(14)(15) that the pauciarticular disease type together with later childhood onset, male preponderance, and seronegativity are features typical of HLA-B27 association, whereas HLA-B27 is not so often positive in the other subgroups.…”

mentioning

confidence: 99%

Mandibular condyle lesions related to age at onset and subtypes of juvenile rheumatoid arthritis in 15‐year‐old children

Karhulahti

Ylijoki

Rönning

1993

European J Oral Sciences

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“…In an earlier study (3), we reported an increased frequency of HLA-Bw35 in patients with systemic onset disease, but HLA-DR alleles were not examined. An association with HLABw35 has been found in patients with the adult onset form of the disease (adult Still's disease) (4) and in some (5,6), but not all series of patients with onset during childhood (7-11). Most subsets of JRA have stronger associations with HLA-DR, or HLA haplotypes including HLA-DR (2,12), than with HLA-A or B alleles.…”

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confidence: 99%

HLA gene frequencies in children and adults with systemic onset juvenile rheumatoid arthritis

Miller

Aaron

Jackson

et al. 1985

Arthritis & Rheumatism

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The HLA genetic region was studied in 51 patients with systemic onset juvenile rheumatoid arthritis: 35 with childhood onset and 16 with adult onset (adult Still's disease). HLA genotypes were established by including family members, 261 of whom were also typed in the study. The most marked difference between patients and controls involved the HLA-DR4 gene, which occurred with a frequency of 0.348 in the childhood onset patients and 0.170 in the controls (x2 = 8.97, P = 0.0028, adjusted P = 0.017). In contrast, the adult onset patients showed a marginal increase in HLA-DR7, but were similar to controls with respect to HLA-DR4. HLA-Bw35 was increased in children with systemic onset disease, in accordance with earlier findings. The results suggest that patients with systemic onset juvenile rheumatoid arthritis have complex HLA associations which are different in childhood onset and adult onset disease.

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Population genetics and molecular biology of the childhood chronic arthropathies

Maksymowych¹,

Glass²

1988

Baillière's Clinical Rheumatology

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On the heterogeneity of HLA association in juvenile rheumatoid arthritis

Cited by 3 publications

References 2 publications

Mandibular condyle lesions related to age at onset and subtypes of juvenile rheumatoid arthritis in 15‐year‐old children

Mandibular condyle lesions related to age at onset and subtypes of juvenile rheumatoid arthritis in 15‐year‐old children

HLA gene frequencies in children and adults with systemic onset juvenile rheumatoid arthritis

Population genetics and molecular biology of the childhood chronic arthropathies

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