Population genetics and molecular biology of the childhood chronic arthropathies

Maksymowych, Walter P.; Glass, David N.

doi:10.1016/s0950-3579(88)80033-5

Cited by 9 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of pairs of affected siblings has demonstrated linkage of this form of JRA with the HLA complex, although there are many HLA specifi cities associated with the disease, including HLA-DR5, DR6, DR8, and DPw2 (62)(63)(64). Molecular genotyping analyses have refi ned these studies but seem to point to a fairly heterogeneous set of contributing alleles.…”

Section: Juvenile Ramentioning

confidence: 99%

MHC Class-II Molecules and Autoimmunity

Nepom

Erlich

1991

Annu. Rev. Immunol.

486

197

View full text Add to dashboard Cite

Molecular and genetic studies of HLA class-II genes provide new insights into the basis for MHC associations with autoimmunity. Polymorphisms among class-II genes identify specific haplotypes associated with autoimmune diseases such as type-I diabetes, rheumatoid arthritis, celiac disease, and pemphigus vulgaris. In some cases, single genes within those haplotypes are themselves implicated in disease susceptibility. Interactions, both cis and trans, between candidate susceptibility genes suggest a number of possible mechanisms critical for autoimmune triggering events involving class-II molecules. Amino acid sequence comparisons between products of candidate susceptibility genes and other class-II genes pinpoint a limited number of critical sites within HLA molecules which appear to be responsible for pathogenic events.

show abstract

Section: Juvenile Ramentioning

confidence: 99%

MHC Class-II Molecules and Autoimmunity

Nepom

Erlich

1991

Annu. Rev. Immunol.

486

197

View full text Add to dashboard Cite

show abstract

“…Relatively little is known of risk factors for JRA, other than the age and sex patterns noted above. Heritability is suspected in the occurrence of JRA, as the disease shows higher concordance rates among monozygotic (44%) compared to dizygotic (4%) twins (93,94). Genetic predisposition is further supported by familial aggregation and several reports of HLA associations with different clinical subsets of JRA (3,911.…”

Section: Prevalence and Incidence Sle Is A Relatively Un-mentioning

confidence: 99%

Epidemiologic perspectives on women and arthritis: An overview

Hannan

1996

Arthritis & Rheumatism

View full text Add to dashboard Cite

Being a woman is the primary risk factor for the rheumatic diseases, yet many researchers and clinicians seldom focus on the link between women and arthritis. This paper reviews the extent and impact of rheumatic disease on women, incidence and prevalence rates of selected rheumatic diseases with sex differences, the major findings of musculoskeletal epidemiologic studies including well-known risk factors, and current theories of the basis and rationale for sex differences. This basic foundation should indicate why it is important to consider women and rheumatic disease.Women are more susceptible than men to some rheumatic diseases. Also, there are rheumatic diseases in mates for a population, or information on the scope of the problem. These estimates are often difficult to provide in the rheumatic diseases, because the prevalence or incidence rates are not always population-based. Secondly, and perhaps more commonly, epidemiologic studies examine risk factors, leading to inferences on causality and perhaps allowing insight into disease biology, or encouraging preventive action through modification of risk factors. Third, rheumatic disease epidemiology allows one to look at social and functional consequences of disease. Overall pattern of rheumatic diseasewhich women are more likely to develop more severe matic diseases vary between women and men, often differing with respect to susceptibility, underlying pathogenic mechanisms, or extent of disability. Bench sciences as well as rheumatic disease epidemiology provide additional insight to the explanation of these sex differences.Rheumatic disease epidemiology provides several vantage points to examine rheumatic diseases. First, epidemiologic studies may provide prevalence estiRheumatic disorders are extremely common, affectdifferent conditions (1,Z). Nearly one-third of United States adults are affected by arthritis signs or s~p -toms, such as swelling, pain, or limited range of motion (I), and arthritis is cited as the leading health problem for US adults over age 50 (3). More than two-thirds of those affected by rheumatic disease are women. Rheumatic diseases destroy joints, weaken bones and internal organs, adversely affect strength and independence, and can shorten life exuectancv. The symptoms* The extent and impact Of rheuing Over 37 million Americans, and include over 100

show abstract

HLA and T Cell Receptor Polymorphisms in Pauciarticular‐Onset Juvenile Rheumatoid Arthritis

Nepom

Malhotra

Schwarz

et al. 1991

Arthritis & Rheumatism

View full text Add to dashboard Cite

The immunogenetic basis of pauciarticular-onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well-defined group of patients. We found that the DR8 haplotype contributes most of the HLAassociated risk, although alleles at other loci contribute independently. A candidate disease-associated T cell receptor polymorphism, in contrast, was not identified in this population. Mechanistic implications of these findings are discussed.Pauciarticular-onset juvenile rheumatoid arthritis (JRA) is the most common form of JRA, characterized by clinically important articular and ophthalmologic manifestations. It typically affects females, beginning during the first few years of life, with

show abstract

Population genetics and molecular biology of the childhood chronic arthropathies

Cited by 9 publications

References 74 publications

MHC Class-II Molecules and Autoimmunity

MHC Class-II Molecules and Autoimmunity

Epidemiologic perspectives on women and arthritis: An overview

HLA and T Cell Receptor Polymorphisms in Pauciarticular‐Onset Juvenile Rheumatoid Arthritis

Contact Info

Product

Resources

About