On the functional significance of the circuit of papez

Parmeggiani, Pier Luigi; Azzaroni, A; Lenzi, P

doi:10.1016/0006-8993(71)90086-2

Cited by 76 publications

(9 citation statements)

References 48 publications

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“…An important projection to the retrosplenial cortex originates from the hippocampal formation, possibly through a hippocampo-mammilo-thalamo-cortical pathway (Parmeggiani et al, 1971(Parmeggiani et al, , 1974Gabriel and Sparenborg, 1986;Gabriel et al, 1987, Wyss andVan Groen, 1992). Cortical afferents from the subiculum, presubiculum, and postsubiculum also relay hippocampal afferent activity to the retrosplenial cortex (Wyss and Van Groen, 1992).…”

Section: Functional Considerationsmentioning

confidence: 99%

Morphology and topographical organization of the retrospleniocollicular connection: A pathway to relay contextual information from the environment to the superior colliculus

2000

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The retrospleniocollicular connection is of interest because it constitutes one link between the limbic system, which is considered the anatomical substrate of emotional experience, and the superior colliculus (SC), which mediates approach and avoidance behavior. The morphology, topography, and origin of the retrospleniocollicular connections were studied by using anterograde [biotinylated dextranamine 10,000 (BDA)] and retrograde [Fluoro-Gold (FG)] tracers. After BDA injections involving retrosplenial granular and agranular cortices, terminal fibers innervating all collicular layers except stratum griseum superficiale were found throughout nearly the entire colliculi. Axons branched within restricted portions of the dorsoventral collicular axis with variable morphologies, suggesting functional heterogeneity. Terminal fields originating in anterior and posterior regions of the retrosplenial cortex were preferentially distributed in laterodorsal and medioventral collicular regions, respectively, but there were also large, densely innervated regions in which the terminal fields overlapped. FG injections in the SC confirmed the retrospleniocollicular topography and demonstrated that this connection originated from layer V pyramidal cells of all retrosplenial areas. The distribution of retrospleniocollicular boutons was related to that of the AChE modules, which are associated with connections in the intermediate layers of the SC. In lateral portions of the SC intermediate layers, most retrospleniocollicular boutons were found in medium AChE stained regions, whereas in medial portions, they terminated in AChE-poor domains. The present results demonstrate that the retrosplenial cortex is the origin of a broad and dense network of axonal branches that may modulate SC-mediated motor and physiological responses involved in emotional behavior.

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Section: Functional Considerationsmentioning

confidence: 99%

Morphology and topographical organization of the retrospleniocollicular connection: A pathway to relay contextual information from the environment to the superior colliculus

2000

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“…Few physiological studies of the function of the anterior thalamic nuclei projections to the limbic cortex have been conducted. Studies by Parmeggiani et al (1971Parmeggiani et al ( , 1974 suggest that AV is involved in the control of hippocampal output, and they imply a functional role for AV in the Papez's circuit. An interaction between the hippocampus and AV has been confirmed by the studies of Gabriel and colleagues (Gabriel and Sparenborg, 1986;Gabriel et al, 1987), and the electrophysiological study of Finch and colleagues (198433) indicates that layer V pyramidal cells of the retrosplenial granular cortex receive inputs both from the anterior thalamic nuclei and the hippocampal formation.…”

Section: Ad and Av Projectionsmentioning

confidence: 99%

Projections from the anterodorsal and anteroveniral nucleus of the thalamus to the limbic cortex in the rat

Groen

Wyss

1995

J of Comparative Neurology

191

129

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The present study characterized the projections of the anterodorsal (AD) and the anteroventral (AV) thalamic nuclei to the limbic cortex. Both AD and AV project to the full extent of the retrosplenial granular cortex in a topographic pattern. Neurons in caudal parts of both nuclei project to rostral retrosplenial cortex, and neurons in rostral parts of both nuclei project to caudal retrosplenial cortex. Within AV, the magnocellular neurons project primarily to the retrosplenial granular a cortex, whereas the parvicellular neurons project mainly to the retrosplenial granular b cortex. AD projections to retrosplenial cortex terminate in very different patterns than do AV projections: The AD projection terminates with equal density in layers I, III, and IV of the retrosplenial granular cortex, whereas, in contrast, the AV projections terminate very densely in layer Ia and less densely in layer IV. Further, both AD and AV project densely to the postsubicular, presubicular, and parasubicular cortices and lightly to the entorhinal (only the most caudal part) cortex and to the subiculum proper (only the most septal part). Rostral parts of AD project equally to all three subicular cortices, whereas neurons in caudal AD project primarily to the postsubicular cortex. Compared to AD, neurons in AV have a less extensive projection to the subicular cortex, and this projection terminates primarily in the postsubicular and presubicular cortices. Further, the AD projection terminates in layers I, II/III, and V of postsubiculum, whereas the AV projection terminates only in layers I and V.

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“…Since he believed that the cingulate cortex was the cortical receptive area for the emotions, the circuit he proposed was as follows: cingulate cortex-cingulum-hippocampus-fornix-mammillary bodies-mammillothalamic tract-anterior thalamus-cingulate cortex. Parmeggiani, Azzaroni, and Lenzi (1971) have recently studied the transformation of repetitive activity through various parts of this circuit and suggested that it does, in fact, serve as a feedback circuit for the hippocampus. Some of the recent anatomical work cited in this chapter casts doubt on the existence of the circuit, at least in the form envisaged by Papez.…”

Section: Anatomy 139mentioning

confidence: 99%