On the Flavonoid Constituents from the Roots of Scutellaria baicalensis GEORGI. I

Tomimori, Tsuyoshi; Miyaichi, Yukinori; Kizu, Haruhisa

doi:10.1248/yakushi1947.102.4_388

Cited by 66 publications

(32 citation statements)

References 2 publications

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“…2). The presence of compounds identified in this study was determined previously by other authors [32][33][34][35][36][37][38]. The domination of baicalin followed by high amounts of wogonoside were shown earlier, as well [36,37].…”

Section: Resultssupporting

confidence: 79%

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Kosakowska

2017

Herba Polonica

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SummaryIntroduction: Baikal skullcap (Scutellaria baicalensis Georgi) is an important medicinal plant, indigenous to Asia. Due to a wide range of pharmacological activities, its roots has been used for ages in Traditional Chinese Medicine. Recently, the species has become an object of interest of Western medicine, as well. Objective: The aim of the study was to determine the variability of Baikal skullcap population originated from Mongolia and cultivated in Poland, in terms of content and composition of flavonoids in the roots. Methods: The objects of the study were 15 individual plants, selected within examined population and cloned in order to obtain a sufficient amount of raw material. The total content of flavonoids in roots was determined according to Polish Pharmacopeia 6th. The qualitative analysis of flavonoids was carried out using HPLC, Shimadzu chromatograph. Results: The dry mass of roots ranged from 25.88 to 56.14 g × plant-1. The total content of flavonoids (expressed as a quercetin equivalent) varied between 0.17 and 0.52% dry matter (DM). Nine compounds were detected within the group, with oroxylin A 7-Oglucuronide (346.90-1063.00 mg × 100 g-1DM) as a dominant, which differentiated investigated clones at the highest degree (CV=0.27). Baicalin (391.40-942.00 mg × 100 g-1DM), wogonoside (324.00-641.10 mg × 100 g-1DM) and hesperetine 7-O-glucoside (163.00-346.32 mg × 100 g-1DM) were also present in a considerable amounts. Clone 7 was distinguished by the highest content of all investigated compounds, except wogonin and oroxylin A 7-O-glucuronide. Conclusions: Results obtained in present study show a high variability within Baical skullcap investigated population in respect of flavonoid compounds detected in roots. Thus, the results may be used in future investigations concerning the selection and breeding of this species.

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Section: Resultssupporting

confidence: 79%

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Kosakowska

2017

Herba Polonica

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“…The EtOAc fraction of wogonoside gave the metabolite M1 (12 mg, wogonin). The metabolite was verified by comparison of its NMR data with those of the reported in literatures (Takido et al, 1975;Tomimori et al, 1982).…”

Section: Metabolism Of Wogonoside By Human Fecal Microfloramentioning

confidence: 80%

“…The precipitate was filtered through a glass filter and washed with cold H2O to yield purified wogonoside (1.5 g). These compounds were identified by comparison of their NMR data with those of the reported in literature (Takido et al, 1975;Tomimori et al, 1982;Lee et al, 2003).…”

Section: Isolation Of Wogonoside From the Rhizome Of Sbmentioning

confidence: 99%

Metabolism of Wogonoside by Human Fecal Microflora and Its Anti-pruritic Effect

Trinh¹,

Jang²,

Han³

et al. 2009

Biomolecules and Therapeutics

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-To understand the relationship between the metabolism of wogonoside from the rhizome of Scutellaria baicalensis, and its anti-pruritic effect, we anaerobically incubated it with human fecal microflora, identified its metabolite identified, and investigated its anti-pruritic effect in compound 48/80 or histamineinduced pruritic mice. Wogonoside was metabolized to wogonin, with metabolic activity of 6.9 ± 5.1 nmol/h/ mg wet weight of fecal microflora. Orally administered wogonoside had more potent anti-scratching behavioral effect in compound 48/80 or histamine-treated mice than intraperitoneally treated one, apart from orally administered its metabolite, wogonin, which was more potent than the orally administered one. Wogonoside showed more potent anti-pruritic effects when administered at 5 h prior to the pruritic agent treatment than when administered at 1 h before. However, wogonin orally administered 1 h before the treatment with pruritic agents showed a more potent anti-pruritic effect than when treated at 5 h before. Orally administered wogonoside may be metabolized to wogonin in the intestine and its anti-scratching behavioral effect may be dependent on its metabolism by intestinal microflora.

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“…The mixture of ethanol and water was the most efficient one for extracting the active components of S. baicalensis G. among the three kinds of mixtures, but in the case of M. japonicus M. A., the extract by the mixture of methanol and water was the most active. Because S. baicalensis G. contains many kinds offlavonoids, which can be extracted efficiently with 50% ethanol/water, 13) and M. japonicus M. A. contains some tannins, which can be extracted efficiently with 50% methanol/water or 60% acetone/water, this results may indicate that these flavonoids and tannins contribute to the superoxide-scavenging activities greatly in these two kinds of plants. The IC so of 10.57 ,ug/ml of 50% methanol/water extract of M. japonicus M. A. was comparable to some other Chinese medicines that have been reported to be superoxide-scavenging active.…”

mentioning

confidence: 92%

Superoxide-scavenging and Tyrosinase-inhibitory Activities of the Extracts of Some Chinese Medicines

Miao

Kayahara

Tadasa

1997

Bioscience, Biotechnology, and Biochemistry

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On the Flavonoid Constituents from the Roots of Scutellaria baicalensis GEORGI. I

Cited by 66 publications

References 2 publications

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Metabolism of Wogonoside by Human Fecal Microflora and Its Anti-pruritic Effect

Superoxide-scavenging and Tyrosinase-inhibitory Activities of the Extracts of Some Chinese Medicines

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