On the Effect of Estrogen Receptor Agonists and Antagonists on the Mouse Hair Follicle Cycle

Smart, Robert C.; Oh, Hye Sun

doi:10.1046/j.1523-1747.1998.00257.x

Cited by 10 publications

(9 citation statements)

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“…Several studies have demonstrated the influence of oestrogen on the murine and other mammalian hair cycle; however, it is clear that the distribution, expression and biological activity of oestrogen receptors in murine models may be quite different than in humans 7–13 . In a recent study, a topical anti‐oestrogen that caused hair growth in a murine model was ineffective in humans 14 .…”

Section: Oestrogens and The Hair Folliclementioning

confidence: 99%

“…[5][6][7] Several studies have demonstrated the influence of oestrogen on the murine and other mammalian hair cycle; however, it is clear that the distribution, expression and biological activity of oestrogen receptors in murine models may be quite different than in humans. [7][8][9][10][11][12][13] In a recent study, a topical antioestrogen that caused hair growth in a murine model was ineffective in humans. 14 In vitro studies have shown that organ culture of human scalp hair follicles exposed to estradiol results in decreased growth whereas cells of the dermal papilla responded with proliferation.…”

Section: Oestrogens and The Hair Folliclementioning

confidence: 99%

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Hormonal changes in menopause: do they contribute to a ‘midlife hair crisis’ in women?

Mirmirani

2011

British Journal of Dermatology

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Female pattern hair loss is a common problem affecting a large number of women worldwide but beset by a paucity of research. The study of androgens has hitherto dominated the field of hair biology but there is increasing scientific and clinical data to suggest that nonandrogen signals can also affect the folliculosebaceous unit, especially in women. The discovery of oestrogen receptor beta has renewed and redefined prior concepts of oestrogen activity and signalling in hair biology. It is postulated that oestrogens modulate hair growth by their influence on a number of other hormones, growth factors, transcription factors and cytokines. The menopause is a period in which significant changes in oestrogen levels are recorded, and this review discusses studies that help to clarify the link between menopause and the perception of thinning hair. In a study of pre- and postmenopausal women without alopecia, menopausal status significantly influenced hair parameters, specifically hair growth rate, percentage anagen and hair diameter distributions, most notably in the frontal scalp. Hair density decreased with age, but was not correlated with menopausal status. Analyses of hair amount using a model of hair density and hair diameters suggest that the impact of changing hair parameters is most notable in the mid-forties for women.

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Section: Oestrogens and The Hair Folliclementioning

confidence: 99%

Section: Oestrogens and The Hair Folliclementioning

confidence: 99%

Hormonal changes in menopause: do they contribute to a ‘midlife hair crisis’ in women?

Mirmirani

2011

British Journal of Dermatology

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“…This inhibition slows the conversion of androstenedione to testosterone and increases the conversion of testosterone to 17β-estradiol and the conversion of androstendione to estrone, thus improving hair growth. However, 17α-estradiol does not exhibit estrogen activity or exhibit only very weak activity181920. Kim et al21 reported that the hair count and thickness steadily increased after application of topical 17α estradiol when compared with the baseline.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

et al. 2017

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BackgroundA variety of agents have been used to treat female pattern hair loss (FPHL), including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, and mineral supplements. Compared with these single agent regimens, combination therapies could be a better therapeutic option in expectation of superior treatment outcome.ObjectiveThis study was designed to determine the efficacy of a combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil in Korean patients with FPHL.MethodsTherapeutic efficacy was evaluated in 34 women who applied topical 0.025% 17α-estradiol and 3% minoxidil once daily for more than 6 months. Phototrichogram analysis was performed before and after therapy. The efficacy was evaluated with respect to total hair count, hair caliber (as assessed by phototrichogram analysis), and photographic assessment.Results Total hair count and hair caliber both increased from baseline to 6 months in patients treated with the combination therapy of topical 0.025% 17α-estradiol and 3% minoxidil (p<0.001). Photographic assessment also revealed significant disease improvement, thus supporting the therapeutic efficacy.ConclusionA combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil can be tried as an effective treatment for FPHL.

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“…Topical application of ER agonist on shaved mouse skin has been reported to arrest follicles in telogen, whereas topical application of ER antagonist causes telogen follicles to enter anagen. This result has been debated [68, 69], so the role of estrogen action on hair cycling is unclear.…”

Section: Sex Steroids: Androgens and Estrogenmentioning

confidence: 99%

Molecular Genetic and Endocrine Mechanisms of Hair Growth

Alonso

Rosenfield²

2003

Horm Res Paediatr

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The prenatal morphogenesis of hair follicles depends upon a precisely regulated series of molecular genetic processes. Hormones and their receptors play prominent roles in modulating postnatal hair cycling, which recapitulates some aspects of morphogenesis. The responses to androgen are the most obvious of these. The postnatal androgen sensitivity of pilosebaceous units in different skin areas is programmed during prenatal development to permit clinical outcomes such as hirsutism and pattern baldness. Thyroid hormone, glucocorticoids, insulin-like growth factor-I, and prolactin have clinically significant effects on specific aspects of hair growth. The nuclear receptors vitamin D receptor and retinoid X receptor are essential for postnatal hair cycling. Other hormones have less clear effects on hair growth. Advances in research on the interaction of hormone target genes with the biological processes involved in hair morphogenesis and cycling can be expected to improve management of hirsutism and alopecia.

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On the Effect of Estrogen Receptor Agonists and Antagonists on the Mouse Hair Follicle Cycle

Cited by 10 publications

References 1 publication

Hormonal changes in menopause: do they contribute to a ‘midlife hair crisis’ in women?

Hormonal changes in menopause: do they contribute to a ‘midlife hair crisis’ in women?

Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

Molecular Genetic and Endocrine Mechanisms of Hair Growth

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