Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

Choe, Sung Jay; Lee, Solam; Choi, Jinseok; Lee, Won‐Soo

doi:10.5021/ad.2017.29.3.276

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Minoxidil for FPHL has been proven to be effective in many studies [5] [6] [10] [11] [12]. Minoxidil induces cutaneous blood flow due to vasodilatory properties [13], and up-regulates vascular endothelial growth factor (VEGF), which helps in maintaining dermal papilla vasculature and hair growth [14].…”

Section: Discussionmentioning

confidence: 99%

“…Various medical therapies have been used to treat FPHL, including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, mineral supplements, growth factors, surgery, and light treatment have been used [5] [6]. Combination therapies are often preferred, because combining medications with different mechanisms of action enhances the efficacy [5] [6] [7].…”

Section: Introductionmentioning

confidence: 99%

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Combination Therapy to Treat Asian Female Pattern Hair Loss

Tanaka¹,

Aso²,

Ono³

2019

JCDSA

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Background: Hair loss in women has a various psychosocial impact and effective treatments have been required. Camouflaging products which cover exposed areas on the scalp and hide visible hair loss are common, but medical therapies for female pattern hair loss (FPHL) are not so common. We have treated patients with FPHL using our combination therapy that consists of oral spironolactone, oral and topical minoxidil, and an injectable treatment for six years. Methods: 4568 female patients were treated between the years 2013 and 2018. Our combination therapy consists of 25 mg oral spironolactone once daily, 2.5 mg oral and 5% solution topical minoxidil twice daily, and an injectable treatment once monthly for 6 -12 months. Digital photographs were taken pre-and post-treatment, and patient assessments were recorded after 6 and 12 months post-treatment. Results: Significant improvement was observed compared to the pre-treatment for all patients in the digital photographs. 95% and 96% of patients reported satisfaction with the results of the treatment after 6 and 12 months post-treatment, respectively. Minor complications were observed in a total of 223 (4.9%) patients, characterized by slight pain and bleeding due to injection, slight palpitation, swelling, hair growth in undesirable areas, headache, dizziness, itching. The seminor complications resolved spontaneously. No treatment-related adverse events were observed. Conclusion: A combination of these therapeutic options offers rapid and highly efficacious treatment for FPHL with minimal complications, and is recommended as an effective treatment for FPHL.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination Therapy to Treat Asian Female Pattern Hair Loss

Tanaka¹,

Aso²,

Ono³

2019

JCDSA

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“…Inclusion criteria and exclusion criteria for the study are summarized in Table 1. All patients were instructed to apply 1 mL of the assigned topical solution every night, on the vertex and frontal mineral supplements, and prostaglandin analogs, as well as surgical therapy and light therapy [10]. The weak estrogen 17α-estradiol has been used for many years as a 0.25-mg/mL topical alternative for the treatment of both male androgenetic alopecia and FPHL given the absence of feminizing estrogenic activity [11] and its ability to weakly inhibit 5α-reductase.…”

mentioning

confidence: 99%

Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients

Rossi

Magri

D’Arino

et al. 2020

Dermatol Pract Concept

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Background and Objectives: Female pattern hair loss (FPHL) is a common form of scalp hair loss that occurs in 38% of females. Currently, minoxidil solution is the only therapy approved by the US Food and Drug Administration, but many other treatments are used, including cyproterone acetate, spironolactone, topical 17α-estradiol, and prostaglandin analogs. Systemic finasteride has been considered a treatment option in women even though its teratogenic effects tend to limit its prescription. Recently, topical finasteride has been evaluated to limit the side effect profile of the drug. The objective of the present study is to compare retrospectively the efficacy of topical 0.05% 17α-estradiol solution and a 0.5% finasteride lotion in the treatment of FPHL. Patients and Methods: We enrolled 119 postmenopausal female patients. The first group comprised 69 women treated with finasteride 0.5% and minoxidil 2%. The second group included 50 women treated with 17α-estradiol 0.05% and minoxidil 2%. At baseline and at 6- and 12- to 18-month follow-up, global photographs were systematically taken. Three operators blind to the prescribed treatment evaluated photographs using a 7-point scale. One-way analysis of variance and unpaired Student t tests were performed to analyze 7-point scale scores. Results: The improvement was statistically significant from 6 months to 12-18 months, both for finasteride (P < 0.005) and 17α-estradiol (P < 0.05). The efficacy of topical finasteride was significantly greater than that of 17α-estradiol solution, both at the 6-month (P < 0.05) and at the 12- to 18-month follow-up (P < 0.005). In general, the highest improvement was observed after 12-18 months of treatment with topical finasteride therapy. Conclusions: Topical finasteride 0.5% in combination with minoxidil 2% could represent a valid therapeutic option for the treatment of postmenopausal FPHL, showing higher efficacy than topical 17α-estradiol with minoxidil 2% both at 6-month and 12- to 18-month follow-up.

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Estrogens

Anastassakis¹

2022

Androgenetic Alopecia From a to Z

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Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

Cited by 7 publications

References 23 publications

Combination Therapy to Treat Asian Female Pattern Hair Loss

Combination Therapy to Treat Asian Female Pattern Hair Loss

Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients

Estrogens

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