On the design and properties of scaffolds based on vertically aligned carbon nanotubes transferred onto electrospun poly (lactic acid) fibers

Rodrigues, Bruno V. M.; Razzino, Claudia A.; Oliveira, Francílio de Carvalho; Marciano, Fernanda Roberta; Lobo, Anderson Oliveira

doi:10.1016/j.matdes.2017.04.074

Cited by 15 publications

(4 citation statements)

References 63 publications

(68 reference statements)

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“…Many biocompatible polyesters have found a prominent place in biomedical applications due to their easy processability. Among numerous examples, we can highlight the poly(lactic acid) (PLA), ,, poly(butylene adipate- co -terephthalate) (PBAT), , and polycaprolactone (PCL) due to a unique combination of their properties, including renewability, biocompatibility,, and relatively low cost. However, one can say that special attention has been directed to PLA over the usual polymers/polyesters for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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The ability of mimicking the extracellular matrix architecture has gained electrospun scaffolds a prominent space into the tissue engineering field. The high surface-to-volume aspect ratio of nanofibers increases their bioactivity while enhancing the bonding strength with the host tissue. Over the years, numerous polyesters, such as poly(lactic acid) (PLA), have been consolidated as excellent matrices for biomedical applications. However, this class of polymers usually has a high hydrophobic character, which limits cell attachment and proliferation, and therefore decreases biological interactions. In this way, functionalization of polyester-based materials is often performed in order to modify their interfacial free energy and achieve more hydrophilic surfaces. Herein, we report the preparation, characterization, and in vitro assessment of electrospun PLA fibers with low contents (0.1 wt %) of different curcuminoids featuring π-conjugated systems, and a central β-diketone unit, including curcumin itself. We evaluated the potential of these materials for photochemical and biomedical purposes. For this, we investigated their optical properties, water contact angle, and surface features while assessing their in vitro behavior using SH-SY5Y cells. Our results demonstrate the successful generation of homogeneous and defect-free fluorescent fibers, which are noncytotoxic, exhibit enhanced hydrophilicity, and as such greater cell adhesion and proliferation toward neuroblastoma cells. The unexpected tailoring of the scaffolds’ interfacial free energy has been associated with the strong interactions between the PLA hydrophobic sites and the nonpolar groups from curcuminoids, which indicate its role for releasing hydrophilic sites from both parts. This investigation reveals a straightforward approach to produce photoluminescent 3D-scaffolds with enhanced biological properties by using a polymer that is essentially hydrophobic combined with the low contents of photoactive and multifunctional curcuminoids

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Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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“…Conductive bone-repair materials have been constructed using CNTs because they improve electrochemical and electron conduction connections between associated biomolecules and proteins, thus accelerating osteoblast proliferation and bone formation [56]. Osteoblast function is enhanced by electrical signals [57]. Adding CNTs to traditional scaffold materials can significantly improve their mechanical properties and endow biomaterials with electrical conductivity, which are regarded as bone-repair implant materials with clinical application potential [58].…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

et al. 2023

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Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone injury repair. First, an overview of the hierarchical architecture from the macroscale to the nanoscale of natural bone is presented, as these bone tissue microstructures and compositions are the basis for constructing bone substitutes. Next, urgent clinical issues associated with bone injury that require resolution and the potential of nanomaterials to overcome them are discussed. Finally, nanomaterials are classified as inorganic or organic based on their chemical properties. Their basic characteristics and the results of related bone engineering studies are described. This review describes theoretical and technical bases for the development of innovative methods for repairing damaged bone and should inspire therapeutic strategies with potential for clinical applications.

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“…Here, the superhydrophilic functionalization of CNT is mandatory for the deposition of nHAp. This work was furthered by Rodrigues et al and Stocco et al, who transferred the scaffold to electrospun poly(lactic acid) and polycaprolactone fibers, respectively, for osteochondral and meniscus tissue engineering. , Other therapeutic applications also came about, including the use of oxygen plasma treated VACNT scaffolds for photodynamic therapy to cultivate and then eradicate Tritrichomona foetus parasite . This technique shows potential for the usage of VACNT in tumor treatment.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Vertically Aligned Carbon Nanotubes as a Unique Material for Biomedical Applications

Kohls

Ditty

Dehghandehnavi

et al. 2022

ACS Appl. Mater. Interfaces

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Vertically aligned carbon nanotubes (VACNTs), a unique classification of CNT, highly oriented and normal to the respective substrate, have been heavily researched over the last two decades. Unlike randomly oriented CNT, VACNTs have demonstrated numerous advantages making it an extremely desirable nanomaterial for many biomedical applications. These advantages include better spatial uniformity, increased surface area, greater susceptibility to functionalization, improved electrocatalytic activity, faster electron transfer, higher resolution in sensing, and more. This Review discusses VACNT and its utilization in biomedical applications particularly for sensing, biomolecule filtration systems, cell stimulation, regenerative medicine, drug delivery, and bacteria inhibition. Furthermore, comparisons are made between VACNT and its traditionally nonaligned, randomly oriented counterpart. Thus, we aim to provide a better understanding of VACNT and its potential applications within the community and encourage its utilization in the future.

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On the design and properties of scaffolds based on vertically aligned carbon nanotubes transferred onto electrospun poly (lactic acid) fibers

Cited by 15 publications

References 63 publications

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Vertically Aligned Carbon Nanotubes as a Unique Material for Biomedical Applications

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