On the complex forming tendency of phenolic hydroxyl with UO22+

Bartüšek, M.; Sommer, L.

doi:10.1016/0022-1902(65)80132-4

Cited by 34 publications

(20 citation statements)

References 18 publications

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“…Uranium(VI) has great affinity for phenolic oxygen at physiological pH (Bartušek and Sommer 1965;Grenthe et al 2006). The stabilities of U(VI)-tiron and U(VI)-tiron 2 are log K 110 ϭ 14 and 1og ␤ 120 ϭ 26, respectively (Singh and Saxena 1990).…”

Section: Structures and Stabilities Of U(vi) Complexesmentioning

confidence: 98%

Lauriston S. Taylor Lecture: The Quest for Therapeutic Actinide Chelators

Durbin¹

2008

Health Physics

106

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All of the actinides are radioactive. Taken into the body, they damage and induce cancer in bone and liver, and in the lungs if inhaled, and U(VI) is a chemical kidney poison. Containment of radionuclides is fundamental to radiation protection, but if it is breached accidentally or deliberately, decontamination of exposed persons is needed to reduce the consequences of radionuclide intake. The only known way to reduce the health risks of internally deposited actinides is to accelerate their excretion with chelating agents. Ethylendiaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) were introduced in the 1950's. DTPA is now clinically accepted, but its oral activity is low, it must be injected as a Ca(II) or Zn(II) chelate to avoid toxicity, and it is structurally unsuitable for chelating U(VI) or Np(V). Actinide penetration into the mammalian iron transport and storage systems suggested that actinide ions would form stable complexes with the Fe(III)-binding units found in potent selective natural iron chelators (siderophores). Testing of that biomimetic approach began in the late 1970's with the design, production, and assessment for in vivo Pu(IV) chelation of synthetic multidentate ligands based on the backbone structures and Fe(III)-binding groups of siderophores. New efficacious actinide chelators have emerged from that program, in particular, octadentate 3,4,3-LI(1,2-HOPO) and tetradentate 5-LIO(Me-3,2-HOPO) have potential for clinical acceptance. Both are much more effective than CaNa3-DTPA for decorporation of Pu(IV), Am(III), U(VI), and Np(IV,V), they are orally active, and toxicity is acceptably low at effective dosage.

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Section: Structures and Stabilities Of U(vi) Complexesmentioning

confidence: 98%

Lauriston S. Taylor Lecture: The Quest for Therapeutic Actinide Chelators

Durbin¹

2008

Health Physics

106

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Section: Introductionmentioning

confidence: 99%

“…Several authors were interested in the polymerization and hydrolysis of -and Th(IV)-Tiron chelates [14][15][16][17]. Sommer et al [14] were interested in the equilibria of -Tiron complex-MLH type protonated complexwhich hydrolyze to dimeric hydrolytic species M 2 L 2 ( OH ) . On the other hand, Martell and coworkers [15][16][17] indicated the formation of a unique complex of Th 3+ ion with Tiron that had the empirical formula (ThA 1.5 .…”

Section: Introductionmentioning

confidence: 99%

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Stabilities of Scandium(III)- and Yttrium(III)-Tiron Chelates and their hydrolytic behavior

2005

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The interactions of Sc 3+ and Y 3+ ions with disodium 1,2-dihydroxybenzene-3,5-disulfonate (Na 2 H 2 L, where H 2 L 2-= Tiron) were investigated in aqueous solution by means of potentiometric and spectroscopic methods. The coordination of Tiron to Sc 3+ and Y 3+ takes place through two phenolic oxygen atoms of catecholate ion in different stoichiometries. Thus, the binding of Tiron to Sc 3+ occurs either in 1 : 1 or 1 : 2 molar ratios; they have resulted by the formation of [ ScL ] -and [ScL 2 ] 5-type complexes, respectively. On the other hand, Y 3+ ion behaves like Th 4+ and Ln 3+ ions toward Tiron. It forms [YL] -type complex in 1 : 1 molar ratio; but in 1 : 2 or in higher molar ratios, only unique [ Y 2 L 3 ] 6-type complex formation takes place. The formation constants of [ ScL ] -, [ ScL 2 ] 5-, [ YL ] -, and [ Y 2 L 3 ] 6-complexes were determined by analysis of the potentiometric data in ionic medium of 0.1 M KNO 3 or NaClO 4 at 25° C. The hydrolytic reactions of Sc(III) and Y(III) complexes with Tiron were determined from potentiometric data and the formation constants of [ ScL ( OH )] 2-and [ YL ( OH )] 2-were also calculated.g°

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“…Seawater contains about 0.55 M NaCl and 2.5 mM bicarbonate ion; its pH is 7.8 to 8.2. 6 Examples of well-studied ligands of uranyl ion are carboxylates 3,7,8 such as EDTA analogues, 9,10 phenols, 3,11 amidoximes, 12 and ␤-ketones. 2,13 In particular, efforts have been directed toward selective molecular recognition of uranyl ion with macrocyclic host molecules including crown ethers and calixarenes.…”

Section: Introductionmentioning

confidence: 99%