On the Chemical Constituents of Dipsacus asper

Tian, Xiaofeng; Wang, Yinghong; Liu, Hongyue; Yu, Shi‐Shan; Fang, Wei‐Shuo

doi:10.1248/cpb.55.1677

Cited by 41 publications

(36 citation statements)

References 11 publications

(4 reference statements)

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“…While there is no experimental research investigating teasel root's anticancer effects, a recent study has suggested that its antioxidant properties may contribute to a potential treatment for Alzheimer's disease (Zhang et al , 2003). Ethanol extracts of Dipsacus asper are known to contain phenolic acids including caffeic acid, 2,6-dihydroxycinnamic acid, vanillic acid, 2′-O-caffeoyl- D -glucopyranoside ester, and caffeoylquinic acid, iridoid glucosides, triterpenoids oleanic acid and akebiasaponin D (Tian et al , 2007). Teasel root is commonly sold with a suggested product dose of 6-21 g/day and categorized as an AHPA-BSH `Class 1 herb`; therefore this herb holds considerable promise as a holistic anticancer CAM (McGuffin, 1997).…”

Section: Discussionmentioning

confidence: 99%

In vitroscreening for the tumoricidal properties of international medicinal herbs

Mazzio

Soliman

2008

Phytotherapy Research

139

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There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC 50 = 31-490 μg/mL) in order of the lowest LC 50 Dioscorea villosa (Dioscoreaceae) > Sanguinaria canadensis (Papaveraceae) > Dipsacus asper (Dipsacaceae) > Populus balsamifera (Salicaceae) > Boswellia carteri (Burseraceae) > Cyamopsis psoralioides (Fabaceae) > Rhamnus cathartica (Rhamnaceae) > Larrea tridentate (Zygophyllaceae) > Dichroa febrifuga (Hydrangeaceae) > Batschia canescens (Boraginaceae) > Kochia scoparia (Chenopodiaceae) > Solanum xanthocarpum (Solanaceae) > Opoponax chironium (Umbelliferae) > Caulophyllum thalictroides (Berberidaceae) > Dryopteris crassirhizoma (Dryopteridaceae) > Garcinia cambogia (Clusiaceae) > Vitex agnus-castus (Verbenaceae) > Calamus draco (Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum.

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Section: Discussionmentioning

confidence: 99%

In vitroscreening for the tumoricidal properties of international medicinal herbs

Mazzio

Soliman

2008

Phytotherapy Research

139

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“…In our preliminary study, the water extract of the aerial parts of L. japonicum was found to exhibit significant antioxidative activity in the oxygen radical absorbance capacity (ORAC) assay. In order to find new and bioactive components, a further chemical investigation on the aerial parts of this plant was carried out, which resulted in the isolation of a new phenylpropanoid glucoside, 4-O-caffeoyl-D-glucopyranose (1), and a new natural product, 3-O-caffeoyl-D-glucopyranose (2) [8], together with six known compounds, 2-O-caffeoyl-D-glucopyranose (3) [9], 6-Ocaffeoyl-D-glucopyranose (4) [10], 4-O-pcoumaroyl-D-glucopyranose (5) [11], 6-Op-coumaroyl-D-glucopyranose (6) [10], caffeic acid (7) [12], and p-coumaric acid (8) [13] (Figure 1). Here, we report the isolation and structural elucidation of the new compounds and their antioxidative activities.…”

Section: Introductionmentioning

confidence: 99%

A new phenylpropanoid glucoside from the aerial parts ofLygodium japonicum

Duan

Dai

et al. 2012

Journal of Asian Natural Products Research

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A new compound, 4-O-caffeoyl-D-glucopyranose (1), and a new natural product, 3-O-caffeoyl-D-glucopyranose (2), together with six known compounds (3-8) were isolated from the aerial parts of Lygodium japonicum. Their structures were elucidated on the basis of extensive spectroscopic data analyses. The oxygen radical absorbance capacity assay was applied to evaluate their antioxidative capacities in vitro, which revealed that 1-8 showed strong antioxidative properties.

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“…The previous methods of obtaining ASD from medicinal plants were column chromatography with silica gel (Kolno et al, 1990;Zhang and Xue, 1991) and preparative reversed phase HPLC (Tian et al, 2007). However, these methods had defects on industrial-scale process, such as the high cost, long production cycle and low diversion rate.…”

Section: Introductionmentioning

confidence: 99%

Microcrystalline Preparation of Akebia Saponin D for its Bioavailability Enhancement in Rats

et al. 2015

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Akebia Saponin D (ASD) or asperosaponin VI is the most abundant constituent of the rhizome of Dipsacus asper, which has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. In recent years, it was reported that ASD was a potential treatment strategy for Alzheimer's disease (AD). However, the low bioavailability of ASD limited its clinical utility. Microcrystalline preparation is one of the effective methods to improve drug absorption. The drugs prepared by different methods can present different solid forms (polymorphs), and different polymorphs have significantly different bioavailabilities. The objective of this study was to prepare ASD polymorphs using the different preparation processes and to evaluate their physicochemical properties and oral absorption. ASD-2 obtained by the antisolvent process was simpler and had higher recovery (78.5%) than that of ASD-1 by a two-step macroporous resin column separation (56.5%). The ASD polymorphs were characterized using differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). The results revealed that ASD-2 existed in microcrystalline form, while ASD-1 was amorphous. Furthermore, the equilibrium solubility, dissolution in aqueous solution and pharmacokinetic parameters of the samples were determined. ASD-2 showed lower aqueous solubility than that of ASD-1 (p < 0.01). In addition, ASD-2 showed lower dissolution with only 65% of the drug released while ASD-1 had a higher dissolution with 99% of drug released at the end of the 180 min testing period. Although ASD-1 significantly increased solubility and dissolution, the AUC 0-20h of ASD-2 was 4.3 times that of the amorphous ASD-1 in vivo. Data suggest that the microcrystalline preparation of ASD-2 is not only reasonable in economy and suitable for large-scale preparation, but also a promising method to enhance bioavailability of ASD.

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On the Chemical Constituents of Dipsacus asper

Cited by 41 publications

References 11 publications

In vitroscreening for the tumoricidal properties of international medicinal herbs

In vitroscreening for the tumoricidal properties of international medicinal herbs

A new phenylpropanoid glucoside from the aerial parts ofLygodium japonicum

Microcrystalline Preparation of Akebia Saponin D for its Bioavailability Enhancement in Rats

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