On the application of molecularly imprinted poly(HEMA) as a template responsive release system

Abstract

2-Hydroxy-ethyl-methacrylate-based molecularly imprinted polymer imprinted for hydrocortisone was found to absorb a considerable amount of testosterone. The release of testosterone to water was found to be very slow. Its release was, however, rapid in the presence of the print molecule (hydrocortisone). This opens up the possibility of developing drug release systems capable of modulating the release with respect to the presence of specific molecules. Such systems could be used in the release of steroids and peptides.

Molecularly imprinted polymers for drug delivery

“…If the concentration of the imprint substance decreases, the release stops. A system of these characteristics able to release testosterone at a rate depending on the concentration of hydrocortisone in the medium was described by Sreenivasan [56]. HEMA (1 g) cross-linked with EGDMA (4 g) and imprinted for hydrocortisone (100 mg) in chloroform (6-8 ml) absorbed, after removing the imprint, a considerable amount of testosterone (175 g/100 mg MIP versus 36 g/100 mg control polymer).…”

Impressão molecular: uma estratégia promissora na elaboração de matrizes para a liberação controlada de fármacos

“…Por outro lado, também pode ocorrer um inchaço do polímero decorrente de transição de volume de fase e, conseqüentemente, o enfraquecimento das ligações que estabilizam o complexo. Sreenivasan (1999) sintetizou um polímero capaz de liberar testosterona, em função da concentração de hidrocortisona do meio. A síntese foi feita empregando-se 2-hidroxi-etil-metacrilato como MF e radiação gama (Sreenivasan, 1997) para início e manutenção da polimerização.…”

Molecular imprinting: A new tool for drug innovation

“…1). Sreenivasan was the first to describe this concept by showing the release of testosteron induced by hydrocortison from a hydrocortison-imprinted polymer [22].…”