Molecularly imprinted polymers for drug delivery

Alvarez‐Lorenzo, Carmen

doi:10.1016/j.jchromb.2003.12.032

Cited by 363 publications

(241 citation statements)

References 96 publications

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“…This would prolong the duration of the drug's pharmacological activity, to reduce side-effects, and minimize administration frequency, thus enhancing patient compliance (Cunliffe et al 2005;Alvarez-Lorenzo et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers for α-Tocopherol Delivery

et al. 2008

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Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on α-tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for α-tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more α-tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids.

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Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers for α-Tocopherol Delivery

et al. 2008

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“…1 H NMR spectra were recorded at ambient temperature with the aid of UNITY/ INOVA 300 or 600 MHz spectrometers (Varian) using DMSO-d 6 as a solvent and TMS as an internal reference.…”

Section: Instrumentsmentioning

confidence: 99%

“…Equimolar solutions (0.04 M) of carboxylic acid and dopamine hydrochloride in DMSO-d 6 were prepared, respectively, dried over molecular sieves (4 Å ) and distributed among 11 NMR tubes in such a way that the ratios of monomer and templates varied between 0:1 and 1:0 (with a constant sample volume of 0.7 mL). NMR line width analyse were done simultaneously.…”

Section: Stoichiometry Of the Prepolymerization Complex Determinationmentioning

confidence: 99%

“…In this study, for recognizing from aqueous environment, concept of use of thermosensitive polymers was utilized, where effectiveness of binding molecules can be enhanced at phase transition temperature by decreasing the relative distance of the functional groups inside the imprinted cavities [6]. There were several reports recently focused on the development of temperature sensitive molecularly imprinted polymers.…”

Section: Introductionmentioning

confidence: 99%

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Molecularly imprinted hydrogels for application in aqueous environment

Korytkowska‐Wałach

2012

Polym. Bull.

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Molecularly imprinted thermoresponsive hydrogels for dopamine recognition were synthesized using N-isopropylacrylamide as the temperature-sensitive element, methacrylic acid or itaconic acid as functional monomer and N,N'-methylenebisacrylamide or ethylene glycol dimethacrylate as crosslinking agent. The stoichiometry of the template-functional monomer prepolymerization complexes was determined by 1 H NMR experiments according to the Job method of continuous variation as well as signal line width analysis. It was found that dopamine hydrochloride forms complexes with methacrylic acid and itaconic acid with 1:3 and 2:3 template to functional monomer stoichiometry, respectively. Hydrogels composed of itaconic acid and with appropriate template content revealed the highest efficiency of imprinting process and relatively high selectivity of dopamine hydrochloride rebinding in water near the phase transition temperature.

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“…Specific rebinding of the template occurs because the imprints are complementary to template surface properties, shape, and structure [1,2]. MIPs have demonstrated potential in a variety of fields where defined recognition is required, including separation [3,4], sensing [5][6][7], catalysis [8,9] and drug delivery [10]. Molecular imprinting has previously been applied to small molecules such as amino acids [11,12], toxins [13][14][15] and drugs [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Formation of protein molecular imprints within Langmuir monolayers: A quartz crystal microbalance study

Turner

Wright

Hlady

et al. 2007

Journal of Colloid and Interface Science

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Protein imprinting leading to enhanced rebinding of ferritin to ternary lipid monolayers is demonstrated using a quartz crystal microbalance. Monolayers consisting of cationic dioctadecyldimethylammonium bromide, non-ionic methyl stearate, and poly(ethylene glycol) bearing phospholipids were imprinted with ferritin at the air/water interface of a Langmuir-Blodgett trough and transferred hydrated to hydrophobic substrates for study. This immobilization was shown by fluorescence correlation spectroscopy to significantly hinder any further diffusion of lipids, while rebinding studies demonstrated up to a six-fold increase in ferritin adsorption to imprinted versus control monolayers. A diminished rebinding of ferritin to its imprint was observed through pH reduction to below the protein isoelectric point, demonstrating the electrostatic nature of the interaction. Rebinding to films where imprint pockets remained occupied by the template protein was also minimal. Studies with a smaller acidic protein revealed the importance of the steric influence of poly(ethylene glycol) in forming the protein binding pockets, as albumin-imprinted monolayers showed low binding of ferritin, while ferritin-imprinted monolayers readily accommodated albumin. The controllable structure-function relationship and limitations of this system are discussed with respect to the application of protein imprinting in sensor development as well as fundamental studies of proteins at dynamic interfaces.

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Molecularly imprinted polymers for drug delivery

Cited by 363 publications

References 96 publications

Molecularly Imprinted Polymers for α-Tocopherol Delivery

Molecularly Imprinted Polymers for α-Tocopherol Delivery

Molecularly imprinted hydrogels for application in aqueous environment

Formation of protein molecular imprints within Langmuir monolayers: A quartz crystal microbalance study

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