On the antifungal and antibacterial activity of some trisubstituted organogermanium, organotin and organolead compounds

Laboratory Evaluations of Wood Preservatives. VII. Effect of Chemical Structure on Toxicity of Organotin and Organolead Compounds to Wood-Destroying Fungi

“…No equally comprehensive tests of these fungicides against wood-destroying fungi in a wood medium have been reported elsewhere, but our results can validly be compared with the tests of the same materials against other fungi byKaars Sijpesteijn et al (1962), and of tests of a narrower range of compounds against wood-destroying fungi, in agar by Hof and Luijten (1959), Nishimoto and Fuse (1964), and Richardson (1964), and in wood by Fahlstrom (1958), Hof and Luijten (1959), Richardson (1968) and Levi (1969).…”

“…Kaars Sijpesteijn et al (1962) found that in their tests against microfungi in agar, there was a tendency for the optimum chain length for fungistatic activity to be longer with lead compounds than with the corresponding tin compounds. Our data are not sufficiently precise to demonstrate this with any certainty, but it is clear that, while such an effect might apply to Forties lividus and Poria monticola, a converse effect applies to Coniophora olivacea.…”

Studies in aryltin chemistry: part 7. Spectroscopic and fungicidal studies of somep-substituted tri-aryltin acetates, oxides and hydroxides

“…35 Four-coordinate R 3 GeX compunds are well known but trans-bidentate five-coordinate 'R 3 Ge' systems are very rare indeed. (b) More recently Bu 2 Sn(of)Br (Hof = 3-hydroxyflavone) has been used as a fluorescent probe of the F 1 F 0 -ATPase complex in both the membrane-bound and solubilized form.…”

Germanium: environmental occurrence, importance and speciation

“…These are compounds of the general formula R 3 GeX with R = Me, Et, Pr, Bu, Hex and Ph, and X = Cl or acetate which have been investigated for their antifungal or antibacterial effect. They have been found to have somewhat lower antimicrobial activity than the corresponding organotin compounds and to exhibit a narrower spectrum of applicability (Kaars Sijpesteijn et al 1962). On the other hand, particularly the organogermanium compounds with short carbon chain length appear to be less toxic for mammals than their corresponding organotin counterparts.…”