On so‐called “multiple osteomata” of the tracheal mucous membrane

Muckleston, Harold S.

doi:10.1288/00005537-190912000-00001

Cited by 17 publications

(15 citation statements)

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“…In 1896, Von Schroetter documented the diagnosis in vivo for the first time by using a laryngeal mirror [12]. It was not until 1897 that the earliest bronchoscopic description of TO was firmly given by Killian.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study of Tracheobronchopathia Osteochondroplastica: Findings from a Large Chinese Cohort

Zhu

Huang

et al. 2014

PLoS ONE

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Background and Study AimsTracheobronchopathia osteochondroplastica (TO) is an uncommon disease of the tracheobronchial system that leads to narrowing of the airway lumen from cartilaginous and/or osseous submucosal nodules. The aim of this study is to perform a detailed review of this rare disease in a large cohort of patients with TO proven by fiberoptic bronchoscopy from China.Patients and MethodsRetrospective chart review was performed on 41,600 patients who underwent bronchoscopy in the Department of Respiratory Medicine of Changhai Hospital between January 2005 and December 2012. Cases of TO were identified based on characteristic features during bronchoscopic examination.Results22 cases of bronchoscopic TO were identified. Among whom one-half were male and the mean age was 47.45±10.91 years old. The most frequent symptoms at presentation were chronic cough (n = 14) and increased sputum production (n = 10). Radiographic abnormalities were observed in 3/18 patients and findings on computed tomography consistent with TO such as beaded intraluminal calcifications and/or increased luminal thickenings were observed in 18/22 patients. Patients were classified into the following categories based on the severity of bronchoscopic findings: Stage I (n = 2), Stage II (n = 6) and Stage III (n = 14). The result that bronchoscopic improvement was observed in 2 patients administered with inhaled corticosteroids suggested that resolution of this disease is possible.ConclusionsTO is a benign disease with slow progression, which could be roughly divided into 3 stages on the basis of the characteristic endoscopic features and histopathologic findings. Chronic inflammation was thought to be more important than the other existing plausible hypotheses in the course of TO. Inhaled corticosteroids might have some impact on patients at Stage I/II.

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Section: Discussionmentioning

confidence: 99%

A Clinical Study of Tracheobronchopathia Osteochondroplastica: Findings from a Large Chinese Cohort

Zhu

Huang

et al. 2014

PLoS ONE

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“…The English physician, Wilks (1857), was the first to give an account of 'ossific deposits in the larynx, trachea and bronchi' in a 38-year-old man who died of pulmonary tuberculosis. Further descriptions of the condition appeared (Muckleston, 1909), and Aschoff (1910) named it tracheopathia osteoplastica. In modern times Dalgaard (1947Dalgaard ( , 1955 once again drew attention to the condition.…”

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confidence: 99%

Tracheobronchopathia osteoplastica: Its relationship to primary tracheobronchial amyloidosis

Sakula

1968

Thorax

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“…He reported that the larynx, trachea, and bronchi were covered in small bony plates that were greatest in the anterior portion of the trachea and described as submucosal. 8,9 In 1896, Von Schroetter became the first to document lesions in a living patient using a laryngeal mirror. 7 While Wilks has generally been credited with the first case report, Rotikansky and Luschka reportedly described similar cases in 1855 and 1856, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…2 These diagnoses prompt a biopsy that identifies TPO, though most sources agree that bronchoscopy findings alone are diagnostic and no biopsy is required for classic TPO. 8,9 This notion seems counterintuitive when considering the anatomical configuration of the c-shaped tracheal rings. 3,6 While most studies report sparing of the posterior wall of the trachea, a few studies describe instances of posterior wall involvement.…”

Section: Discussionmentioning

confidence: 99%

“…3,6 While most studies report sparing of the posterior wall of the trachea, a few studies describe instances of posterior wall involvement. 9 Due to its rarity, nodules of the posterior wall warrant biopsy to rule out other more common etiologies with this presentation such as polychondritis, sarcoidosis, amyloidosis, and papillomatosis. However, TPO has also been described projecting from the interspaces of tracheal rings without cartilage connection.…”

Section: Discussionmentioning

confidence: 99%

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