The purpose of this study is to assess the effects on air pollution that may derive from replacing a signal-controlled intersection with a roundabout, using a before-and-after approach. Based on field data collected with a test car instrumented with a Portable Emission Measurement System, the two intersection configurations were compared in terms of emissions of CO 2 , CO, and NO . The existence of significant differences in emissions between the two types of control was assessed by means of a statistical technique known as two-sample biaspect permutation test. In addition, focusing on trips carried out in peak traffic conditions, binary logistic regression models were developed to identify the factors that significantly affect vehicular emissions and to quantify their effect. The findings of our analyses show that emissions of CO 2 and CO are generally lower for the roundabout than for the signal-controlled intersection, while an opposite result arises for NO emissions. As far as other influential factors are concerned, trip direction (reflecting site-specific conditions) and driver behavior have a considerable impact on the emissions of all three pollutants.