On pathogenesis of arterial hypertension in type 2 diabetes mellitus

Volkov, V S; Степанович, Волков Виолен; Rudenko, E V; Владимировна, Руденко Евгения; Rokkina, S A; Анатольевна, Роккина Светлана; Poselyugina, O. B.; Борисовна, Поселюгина Ольга

doi:10.14341/2072-0351-5635

Cited by 2 publications

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References 2 publications

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“…В настоящее время убедительно доказано, что гиперинсулинемия (ГИ), которая является практически облигатным проявлением СД-2, способствует реабсорбции натрия и воды в канальцах, накоплению Na и Ca внутри клетки, повышению активности симпатической нервной системы (СНС) [4,5]. К этому следует добавить, что согласно полученным результатам, больные СД-2 + АГ привычно потребляют в сутки от 10,5 до 17 г ПС [6]. При этом следует учесть, что половина больных СД является соль-чувствительными [2].…”

Section: результаты и обсуждениеunclassified

Comparative analysis of arteriolar Doppler ultrasound parameters in hypertensive patients with or without Type 2 diabetes mellitus

Volkov

Rudenko

Poselyugina

2012

Cardiovasc Ther Prev

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Aim.Using the Doppler ultrasound method, to describe functional status of arterioles in patients with essential arterial hypertension (AH) and individuals with Type 2 diabetes mellitus (DM-2) and concomitant AH.Material and methods.The study included 90 AH patients and 83 patients with DM-2 and AH. Systolic (Vs, cm/s), diastolic (Vd, cm/s), and mean (Vm, cm/s) arteriolar blood flow velocity was measured using the Miniplex Doppler device. The subsequent spontaneous changes in blood flow velocity were registered for one minute and presented as percentages.Results.The maximal blood flow velocity was observed in AH patients, followed by healthy controls and patients with DM-2 and AH. The Vs variation was the largest in healthy people, smaller in AH patients, and the smallest in participants with AH and DM-2. The maximal Vd variation was observed in AH patients, followed by patients with AH and DM-2 and healthy controls.Conclusion.The assessment of arteriolar blood flow velocity provides information about arteriolar tonus and its dynamics over time.

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Section: результаты и обсуждениеunclassified

Comparative analysis of arteriolar Doppler ultrasound parameters in hypertensive patients with or without Type 2 diabetes mellitus

Volkov

Rudenko

Poselyugina

2012

Cardiovasc Ther Prev

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Features of antihypertensive pharmacotherapy in patients with metabolic syndrome and diabetes mellitus

Vlyubchak

Дутова

Romanova

2021

SMJ

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The article describes the results of analyzing the available literature concerning specifics of pharmacotherapy for hypertension in elderly patients and patients with metabolic syndrome and diabetes mellitus. Authors present statistical data on the prevalence of hypertension among elderly patients and the incidence of obesity and diabetes in the Russian Federation. The paper highlights the characteristics of clinical course of hypertension in the older age group including the predominance of isolated systolic hypertension, vascular stiffness, and increased endothelial dysfunction. The need for administration of antihypertensive drugs to reduce the risk of complications and improve the quality of life even in older patients is confirmed. The analysis of data from numerous large studies allowed the authors to identify the main principles for selecting antihypertensive drugs in elderly patients. Slow calcium channel blockers, angiotensin converting enzyme inhibitors, and low-dose diuretics should be prescribed as first-line drugs. At the next stage of treatment, in case of unsatisfactory results of initial therapy, the addition of mineralocorticoid receptor antagonists, alpha-blockers, and selective imidazoline receptor agonists should be considered. The main approaches to antihypertensive therapy in patients with metabolic syndrome and diabetes mellitus are described. The authors note the fact of unfavorable impact of metabolic syndrome on cardiovascular system, which provides rationale for aggressive treatment of hypertension in such clinical cases where several drugs may be used to achieve a stable antihypertensive effect. Diuretics, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers are recommended as first-line antihypertensive pharmacotherapy in these patients. The authors argue in favour of the use of antihypertensive drug combinations in one dosage form as one of the effective ways to solve the problem of adherence to treatment in elderly patients and patients with concomitant metabolic disorders.

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On pathogenesis of arterial hypertension in type 2 diabetes mellitus

Cited by 2 publications

References 2 publications

Comparative analysis of arteriolar Doppler ultrasound parameters in hypertensive patients with or without Type 2 diabetes mellitus

Comparative analysis of arteriolar Doppler ultrasound parameters in hypertensive patients with or without Type 2 diabetes mellitus

Features of antihypertensive pharmacotherapy in patients with metabolic syndrome and diabetes mellitus

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