On Modulation of Cerebral Cholinergic Mechanisms by Endogenous Indoleamines and their Derivatives

Oderfeld-Nowak, B; Aprison, M. H.

doi:10.1007/978-1-4684-8643-8_74

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…The regulation of septohippocampal cholinergic neurons by catecholamines has been delineated by Robinson, Cheney & Costa, (1981) and Butcher, Woolf, Albanese & Butcher, (1981). Oderfeld-Nowak and Aprison (1981) have presented evidence that those same cholinergic mechanisms are modulated by serotonergic indolamines. The interaction between cholinergic hippocampal neurons and adrenergic mechanisms on the one hand, and cholinergic hippocampal neurons and serotonergic mechanisms on the other, are, however, independent of one another (Ladinsky, Consolo, Tirelli, Forloni & Segal, 1981).…”

Section: Cholinergic-aminergic Interactionsmentioning

confidence: 99%

Attention and Para‐Attentional Processing. Event‐Related Brain Potentials as Tests of a Model

Pribram

McGuinness²

1992

Annals of the New York Academy of Sciences

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In 1972 when we began to analyze the vast amount of material from the laboratories of physiological psychologists, we had only a vague conceptualization of what a model of attention might look like. We began where everyone else had, with the view that everything had something to do with "arousal" but with Lacey's (1967) warning in mind that all of the dependent variables might not actually be measuring aspects of the same process. With this warning in mind, we were forced by the data to organize them into a three-systems mode. Since the first publication of this model in 1975, we have found increasing amounts of evidence to support and extend it. This evidence is briefly reviewed in the present paper in terms of the techniques employed in various types of investigation. Further, the current review of data has made it possible to specify the para-attentional substrate (the extrinsic lemniscal primary projection systems) upon which the three systems described in the earlier model operate. The earlier model was based on psychophysiological, neurobehavioral and neurochemical analyses while the current specification results from the results of recordings of event-related brain electrical responses. The conclusions derived from these results can be summarized as follows: First. It has become possible to distinguish controlled attention from the para-attentional pre- and post-attentive automatic processes upon which controls operate. Second. The pre- and post-attentive processes appear to be coordinate with activity in the extrinsic lemniscal primary sensory projection systems. Processing in these systems is reflected in the early components of event-related brain electrical potentials. These extrinsic systems are, however, not just throughputs for further processing. Rather, they are sensitive to the history of reinforcement which the subject has experienced. The concept of a limited channel capacity must, therefore, be modified to encompass this ability of organisms to improve, through practice, their competence to process a great deal of information in parallel. Competence, not capacity, limits central processing span. Third. A set of intrinsic extralemniscal processing systems has been identified to operate via a tecto-tegmental pathway to the reticular nucleus of the thalamus. The later components (N2P3, etc.) of event-related potentials have been shown to reflect processing in these systems and those that control them. Activity in these systems has been related to targeted conscious awareness.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Cholinergic-aminergic Interactionsmentioning

confidence: 99%

Attention and Para‐Attentional Processing. Event‐Related Brain Potentials as Tests of a Model

Pribram

McGuinness²

1992

Annals of the New York Academy of Sciences

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“…Interestingly, several tricy-clic antidepressant compounds with structures similar to those of p-carbolines cause even stronger effects on both AChE (Caratsch and Waser, 1973;Michalek, 1973) and muscarinic receptor binding (Snyder and Yamamura, 1977;Bohman et al, 1981), indicating that this tricyclic stereochemistry is even more favourable for the observed effects. The indole ring itself seems to play a role in the structure of the subsite on the enzyme molecule, but not on the muscarinic receptor one, since indole derivatives like serotonin or tryptamine were found to be noncompetitive inhibitors of AChE (Oderfeld-Nowak and Aprison, 1981).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Studies on the Effect of β‐Carbolines on the Activities of Acetylcholinesterase and Choline Acetyltransferase and on the Muscarinic Receptor Binding of the Rat Brain

Skup

Oderfeld-Nowak

Rommelspacher³

1983

Journal of Neurochemistry

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Acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) activity and muscarinic receptor binding of homogenates from several brain structures were inhibited by beta-carbolines. The inhibition was of the noncompetitive type in the case of the enzyme and of the mixed type in the case of the receptor binding. This effect was most strongly manifested by pyridoindoles(harmane, norharmane), i.e., carbolines containing an aromatic C ring than by the corresponding piperidoindoles (tetrahydroharmane, tetrahydronorharmane), i.e., those with a reduced C ring. The activity of choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6) was not altered. These data are further evidence of the interactions between indoleamine derivatives and the cholinergic system. The results are discussed in terms of their possible biological significance.

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On Modulation of Cerebral Cholinergic Mechanisms by Endogenous Indoleamines and their Derivatives

Cited by 2 publications

References 47 publications

Attention and Para‐Attentional Processing. Event‐Related Brain Potentials as Tests of a Model

Attention and Para‐Attentional Processing. Event‐Related Brain Potentials as Tests of a Model

In Vitro Studies on the Effect of β‐Carbolines on the Activities of Acetylcholinesterase and Choline Acetyltransferase and on the Muscarinic Receptor Binding of the Rat Brain

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