On-line preconcentration techniques in determination of melatonin and its precursors/metabolites using micellar electrokinetic chromatography

Musijowski, Jacek; Poboży, Ewa; Trojanowicz, Marek

doi:10.1016/j.chroma.2005.11.063

Cited by 32 publications

(21 citation statements)

References 52 publications

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“…26 can be calculated from the data in Table 2. 28 or with multivariate optimization in HPLC (44 ng/mL) and CE (13 ng/mL). 29 Although more sensitive methods (1 pg/ mL) have been reported for the precursor of 6HM (M) as RIA in serum, 5a CG-MS in plasma and saliva 6a and LC-tandem MS using stable isotope dilution in human saliva, 7 these analyses involve costly equipment and solvents, in conjunction with complex pre-treatment processes.…”

Section: Analytical Performance Of the Supramolecular Methodsmentioning

confidence: 99%

Supramolecular analytical chemistry: spectrofluorimetric determination of 6-hydroxymelatonin with hydroxypropyl-β-cyclodextrin

Bracamonte¹,

Miñambres²,

Veglia³

2011

Arkivoc

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The effect of the addition of native (α, β and γ) and derivative (methyl-β and hydroxypropyl-β) cyclodextrins (CD) on the fluorescence of 6-hydroxymelatonin (6HM) in water solutions was studied. The fluorescence of the substrate in the presence of hydroxypropyl-β-CD (HPCD) showed the maximum enhancement and the association constant (K A , mol -1 L) was determined (60±2) and interpreted. The fluorescence quantum yield ratio between the complex and free substrate (φ 6HMCD /φ 6HM ) = 6.0±0.2 provides analytical advantages. On the basis of this supramolecular interaction, an alternative and sensitive spectrofluorimetric method for the determination of 6HM was developed with a detection limit of 0.71 ng mL -1 . The validation of the method was performed in urine samples with very good recoveries 95-109 %.

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Section: Analytical Performance Of the Supramolecular Methodsmentioning

confidence: 99%

Supramolecular analytical chemistry: spectrofluorimetric determination of 6-hydroxymelatonin with hydroxypropyl-β-cyclodextrin

Bracamonte¹,

Miñambres²,

Veglia³

2011

Arkivoc

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“…In general, indole and pyrrole show properties different from amines and anilines due to the delocalization of the lone pair of electrons of the nitrogen atom in the aromatic ring, which would be one of the explanations for the potential response here. Because the molecules with indole rings such as serotonin [2 -5], melatonin [8,9], indole alkaloid [10 -12], etc. play significant roles in our biological system, many researchers are focusing their attention on those molecules for sensing targets.…”

Section: Full Papermentioning

confidence: 99%

Potential Response of Monolayer‐Modified Indium Tin Oxide Electrodes to Indole Compounds

et al. 2010

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Potential response of indium tin oxide (ITO) electrode modified by treatment with disuccinimidyl suberate (DSS) was investigated to various target molecules. Distinctively, the DSS-modified ITO electrode exhibited a potential shift to the molecules possessing an indole group such as tryptophan, tryptamine and indole propionic acid, while little response to benzoic acid, phenylalanine, proline, proline amide, and arginine was observed. In addition, the combination of this specificity to indoles and enantioselective affinity of human serum albumin (HSA), which was additionally immobilized on the DSS-modified ITO electrode, brought about enantioselective potential response to tryptophan.

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“…Several analytical techniques have been developed for the simultaneous measurement of 5-HT and MT, liquid chromatography coupled to mass spectrometry and capillary electrophoresis with UV detection being most often used [16][17][18][19]. Although these methods can adequately monitor the levels of 5-HT and MT, they still require skilled personnel and sophisticated and expensive instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin

et al. 2015

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Single-walled carbon nanotubes (SWCNT), multiwalled carbon nanotubes (MWCNT) and graphene have been tested as carbon allotropes for the modification of carbon screen-printed electrodes (CSPEs) to simultaneously determine melatonin (MT) and serotonin (5-HT). Two groups of CSPEs, both 4 mm in diameter, were explored: The first includes commercial SWCNT, MWCNT and graphene, the second includes SWCNT, MWCNT, graphene oxide nanoribbons and reduced nanoribbons that were drop casted on the electrodes. The carbon nanomaterials enhanced the electroactive area in the following order: CSPE

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On-line preconcentration techniques in determination of melatonin and its precursors/metabolites using micellar electrokinetic chromatography

Cited by 32 publications

References 52 publications

Supramolecular analytical chemistry: spectrofluorimetric determination of 6-hydroxymelatonin with hydroxypropyl-β-cyclodextrin

Supramolecular analytical chemistry: spectrofluorimetric determination of 6-hydroxymelatonin with hydroxypropyl-β-cyclodextrin

Potential Response of Monolayer‐Modified Indium Tin Oxide Electrodes to Indole Compounds

Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin

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