On-line microextraction of moxifloxacin using Fe₃O₄ nanoparticle-packed in-tube SPME

Abstract

In the current study, an in-tube solid phase microextraction (SPME) approach based on Fe3O4 nanoparticles packed tube for microextraction and detection of moxifloxacin has been reported. In this regard, the Fe3O4 nanoparticles (NPs) were prepared by a batch synthesis and were introduced into a stainless steel tube by a syringe. Afterward, a strong magnet was placed around the tube, so that the Fe3O4 NPs were retained in the tube and the tube was used in the in-tube SPME-HPLC for the analysis of moxifloxacin in urine samples, which sodium dodecyl sulfate (SDS) was used as bridging agent between the Fe3O4 NPs and moxifloxacin. The operational conditions such as uptake and release times, flow rate and pH of solution were investigated and optimized. According to our findings, the linear range and detection limit (S/N = 3) were 0.1-5000 and 0.03 µg L −1 , respectively. Simplicity and facile automation, rapid analysis, high sensitivity, wide linear range, and fully sorbent collection after analysis are the main advantages of the method.

Green synthesis of magnetic MOF@GO and MOF@CNT hybrid nanocomposites with high adsorption capacity towards organic pollutants

“…). The Fe3O4 MNPs were synthesized via chemical co-precipitation method according to the previous report [49].…”

“…Moreover, the incorporation of superparamagnetic iron (III) oxide nanoparticles (Fe3O4 MNPs) to the MOF@GO or MOF@CNT hybrid nanocomposites can be engineered for the magnetic separation and recovery of the absorbents [47][48][49].…”

Optimization of graphene polypyrrole for enhanced adsorption of moxifloxacin antibiotic: an experimental design approach and isotherm investigation

“…[3]. The other reported methods used a difficult method of preparation and long procedures [2]. A shorter time of contact with GRP-PPY-NP to save time and high efficiency also shows a benefit over the reported methods as they took more time for the process [33].…”

“…Removal of MXF from wastewater was previously reported using different adsorption methods. However, either a long process of preparation with high costs, time consumption, or high temperature such as non-eco-friendly methods were adopted such as biochars [3], metal-organic framework (MOF) [46], natural zeolite [33], in-tube solid-phase microextraction using stainless steel tube by a syringe loaded with Fe 3 O 4 nanoparticles [2], and removal by long synthesis process of NP [6], which considered complicated processes. The removal of other drugs by using different nanoparticles by adsorption was also performed but they didn't achieve the same results as the current work did.…”

Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview

“…Two analytical methods have been reported by the research group of Almadi for the determination of fluoroquinolones in human urine [146,147]. Magnetic nanoparticles functionalized with sodium dodecyl sulfate have been employed for in-tube SPME of moxifloxacin [146]. The authors concluded that the SDS molecules acted as a bridging agent between the analyte and the bare Fe 3 O 4 material, and thus an enhancement of its retention was observed.…”