On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization

Acosta, Gimena; Silva, Raúl Alejandro; Gil, Raúl A.; Gomez, Roxana; Fernández, Liliana Patricia

doi:10.1016/j.talanta.2012.11.045

Cited by 14 publications

(10 citation statements)

References 35 publications

(34 reference statements)

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“…Since most of the drugs in use are chiral, the pharmacological activity is limited to one of the enantiomers, while the other form can show unwanted side effects, antagonistic activities or even toxic effects. Hence, it is of great importance to separate the active components from the less active, inactive, or toxic enantiomers . Li et al.…”

Section: Gold Npsmentioning

confidence: 99%

Recent advances in nanomaterial‐based capillary electrophoresis

et al. 2019

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This review gives a summary of applications of different nanomateials, such as gold nanoparticles (AuNPs), carbon‐based nanoparticles, magnetic nanoparticles (MNPs), and nano‐sized metal organic frameworks (MOFs), in electrophoretic separations. This review also emphasizes the recent works in which nanoparticles (NPs) are used as pseudostationary phase (PSP) or immobilized on the capillary surface for enhancement of separation in CE, CEC, and microchips electrophoresis.

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Section: Gold Npsmentioning

confidence: 99%

Recent advances in nanomaterial‐based capillary electrophoresis

et al. 2019

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“…In order to minimize interferences by matrix effect, a mini-column (mC) of multiwalled carbon nanotubes (MWCNTs) as adsorbent material was used. It was previously activated following the procedure described by Acosta et al [19].…”

Section: The Propulsion System Consisted Of Two Peristaltic Pumps (Gimentioning

confidence: 99%

On-Line Photoinduced Fluorescence for Carbamazepine Determination after Multivariate Optimization

Henestrosa¹,

Peralta²,

Aragón³

et al. 2019

AJAC

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This work presents a simple and sensitive flow injection fluorimetric method for the determination of carbamazepine (CBZ) in pharmaceutical samples. It is based on the fluorescence signal measurement of the product generated by photoinduced (λ ex = 251 nm; λ em = 434 nm) using a flow injection manifold containing an on-line homemade photoreactor. In order to optimize the experimental setup, the variable conditions were studied using a multivariate optimization method, thus finding the set of optimum parameters according to the evaluated responses (sensitivity and sampling frequency) and minimizing the number of experiments performed. Under optimal experimental conditions, linear relationship with good correlation coefficient (0.9956) was found between the fluorescence intensity and CBZ concentration in the range of 0.13-40 µg•mL −1. The limit of detection was 0.04 µg•mL −1. The precision of the method was satisfactory; the values of relative standard deviations were better than 4.36%. The proposed method was validated and successfully applied to the determination of CBZ in pharmaceuticals with good accuracy; being the recovery values from 89.45%-112.20%.

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“…Tygon tubing (Middleton, WI, USA). In order to preconcentrate the analyte, a mini-column of multiwalled carbon nanotubes previously activated following the procedure described by Acosta et al [26] was used as adsorbent material. …”

Section: Accepted Manuscriptmentioning

confidence: 99%