On-line electrochemical derivatization combined with diode-array detection in flow-injection analysis

Opstal, M.A.J. van; Blauw, J.S.; Holthuis, J.J.M.; Bennekom, W.P. van; Bult, A.

doi:10.1016/s0003-2670(00)85900-0

Cited by 13 publications

(2 citation statements)

References 19 publications

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“…Analogously to photochemical reactions, electrochemical processes may also yield species more appropriate for detection. The approach involves redox processes under controlled potential at the electrodes, associated to spectrophotometric detection of the products, as demonstrated in the determination of pharmaceuticals in blood plasma [ 27 ]. The coulometric generation of reagents for chemical derivatization was also described [ 28 ].…”

Section: Chemical Derivatizationmentioning

confidence: 99%

Chemical Derivatization in Flow Analysis

Rocha

Zagatto

2022

Molecules

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Chemical derivatization for improving selectivity and/or sensitivity is a common practice in analytical chemistry. It is particularly attractive in flow analysis in view of its highly reproducible reagent addition(s) and controlled timing. Then, measurements without attaining the steady state, kinetic discrimination, exploitation of unstable reagents and/or products, as well as strategies compliant with Green Analytical Chemistry, have been efficiently exploited. Flow-based chemical derivatization has been accomplished by different approaches, most involving flow and manifold programming. Solid-phase reagents, novel strategies for sample insertion and reagent addition, as well as to increase sample residence time have been also exploited. However, the required alterations in flow rates and/or manifold geometry may lead to spurious signals (e.g., Schlieren effect) resulting in distorted peaks and a noisy/drifty baseline. These anomalies can be circumvented by a proper flow system design. In this review, these aspects are critically discussed mostly in relation to spectrophotometric and luminometric detection.

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Section: Chemical Derivatizationmentioning

confidence: 99%

Chemical Derivatization in Flow Analysis

Rocha

Zagatto

2022

Molecules

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“…On-line derivatization has been coupled with FIA systems and applied to chloride determination [143], bioanalysis in blood plasma [144], enantiomers drugs and other nucleophiles [145], secondary amines in nonaqueous solutions [146] and amino acid determination with on-line hydrolysis of proteins [147].…”

Section: Sampling Systemsmentioning

confidence: 99%

State of the art in on‐line techniques coupled to flow injection analysis FIA/on‐line‐ a critical review

Puchades

Maquieira

Atienza

et al. 1990

Journal of Analytical Methods in Chemistry

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Flow injection analysis (FIA) has emerged as an increasingly used laboratory tool in chemical analysis. Employment of the technique for on-line sample treatment and on-line measurement in chemical process control is a growing trend. This article reviews the recent applications of FlA. Most papers refer to on-line sample treatment. Although FIA is very well suited to continuous on-line process monitoring, few examples have been found in this areamost of them have been applied to water treatment or fermentation processes.

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Etoposide and teniposide

Holthuis

1988

Pharmaceutisch Weekblad Scientific Edition

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On-line electrochemical derivatization combined with diode-array detection in flow-injection analysis

Cited by 13 publications

References 19 publications

Chemical Derivatization in Flow Analysis

Chemical Derivatization in Flow Analysis

State of the art in on‐line techniques coupled to flow injection analysis FIA/on‐line‐ a critical review

Etoposide and teniposide

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