We study the Cauchy problem of three-dimensional compressible non-isentropic magnetohydrodynamic (MHD) fluids in R 3 . Applying delicate energy estimates, initial layer analysis, and continuation theory, we establish the global existence and uniqueness of strong solutions, which may be of possibly large oscillations, provided that the initial data are of small total energy. In particular, both interior and far field vacuum states are allowed. This improves our previous work [23] where the initial quantity ρ 0 L ∞ + H 0 L 3 must be small enough and the viscosity coefficients should satisfy 3µ > λ. Furthermore, we also derive the algebraic decay estimates of the solution. To our best knowledge, this is the first result on time-decay rates of solutions to the Cauchy problem of multi-dimensional compressible non-isentropic MHD equations with vacuum.