On-demand drug release from tailored blended electrospun nanofibers

Amarjargal, Altangerel; Brunelli, Marzia; Fortunato, Giuseppino; Spano, Fabrizio; Kim, Cheol Sang

doi:10.1016/j.jddst.2019.04.004

Cited by 31 publications

(31 citation statements)

References 45 publications

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“…This approach can yield a wide range of drug release profiles, from very rapid release (in seconds) to sustained release over weeks or months. [37,38]. The main weakness of this approach is the commonly observed burst release phenomenon [39].…”

Section: Blend Electrospinningmentioning

confidence: 99%

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

et al. 2021

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Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.

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Section: Blend Electrospinningmentioning

confidence: 99%

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

et al. 2021

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“…Temperature-responsive drug-loaded electrospun NFs are produced from polymers with abruptly varying solubilities [37,81]. This is based on the competition between hydrophilic and hydrophobic molecules on the polymer chain [82,83]. The human body temperature has a restricted range and fluctuates during the day.…”

Section: Temperaturementioning

confidence: 99%

On-Demand Drug Delivery Systems Using Nanofibers

2021

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On-demand drug-delivery systems using nanofibers are extensively applicable for customized drug release based on target location and timing to achieve the desired therapeutic effects. A nanofiber formulation is typically created for a certain medication and changing the drug may have a significant impact on the release kinetics from the same delivery system. Nanofibers have several distinguishing features and properties, including the ease with which they may be manufactured, the variety of materials appropriate for processing into fibers, a large surface area, and a complex pore structure. Nanofibers with effective drug-loading capabilities, controllable release, and high stability have gained the interest of researchers owing to their potential applications in on-demand drug delivery systems. Based on their composition and drug-release characteristics, we review the numerous types of nanofibers from the most recent accessible studies. Nanofibers are classified based on their mechanism of drug release, as well as their structure and content. To achieve controlled drug release, a suitable polymer, large surface-to-volume ratio, and high porosity of the nanofiber mesh are necessary. The properties of nanofibers for modified drug release are categorized here as protracted, stimulus-activated, and biphasic. Swellable or degradable polymers are commonly utilized to alter drug release. In addition to the polymer used, the process and ambient conditions can have considerable impacts on the release characteristics of the nanofibers. The formulation of nanofibers is highly complicated and depends on many variables; nevertheless, numerous options are available to accomplish the desired nanofiber drug-release characteristics.

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“…Besides, it effectively enhances the drug design formulation for the medicine to release from the polymer by amending the balance between polymer and drug in the blend solution. Also, blending electrospun provides a longterm drug release system by drug encapsulation and drug dispersion into the fiber [125,126]. The main weakness of this approach is clearance and denaturation of protein/drug substances with their severe burst release phenomenon, which reduce the lifetime hydrophilic drugs during encapsulation [114].…”

Section: Figure 5 Schematic Represents the Different Drug Incorporation Approach Through Electrospinningmentioning

confidence: 99%

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Zare

Ramakrishna

2020

Proceedings of the 1st International Electronic Conference on Pharmaceutics

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Electrospinning is a powerful and cost-effective method that applies a strong electric field and polymer solution to fabricate versatile nanofiber using a wide array of raw materials for different biological applications. Electrospun nanofibers have developed as potential materials for the manufacturing of nanocarriers for therapeutic platforms due to controllable surface decoration, large surface areas, complex pore structure, good surface functionalization with high biocompatibility. The prominence of this technique is the possibility of merging low soluble drugs loaded in the nanofibers to enhance drug release and bioavailability. Incorporation of metal nanomaterials with electrocatalytic and/or plasmonic features into electrospun polymer nanofiber enhances thermodynamic and mechanical properties to obtain synergetic function and properties. This review comprehensively discusses an overview of theory of electrospinning, progress and concerns, and challenges currently face in fabricating efficient and effective drug delivery systems. Additionally, the drug-loaded into electrospun nanocarriers for drug delivery applications and insights into future prospects were explained.

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On-demand drug release from tailored blended electrospun nanofibers

Cited by 31 publications

References 45 publications

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

On-Demand Drug Delivery Systems Using Nanofibers

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

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