On-demand drug delivery of triptolide and celastrol by poly(lactic-co-glycolic acid) nanoparticle/triglycerol monostearate-18 hydrogel composite for rheumatoid arthritis treatment

Wang, Zefeng; Li, Ruixiang; Zhang, Jiange

doi:10.1007/s42114-022-00493-4

Cited by 25 publications

(18 citation statements)

References 55 publications

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“…Collagen-induced arthritis (CIA) mouse model was constructed according to the previous report. [36,43] The detailed process is as follows: Complete Freund's adjuvant (4 mg mL −1 ) and bovine type II collagen (2 mg mL −1 ) were well mixed (1:1, v/v) and injected subcutaneously into DBA/1 mice (50 µL per mouse). After 21 days, an emulsion of incomplete Freund's adjuvant and bovine type II collagen (2 mg mL −1 ) was again injected subcutaneously (50 µL per mouse) into the DBA/1 mice.…”

Section: Methodsmentioning

confidence: 99%

Folate Receptor‐Targeted NIR‐II Dual‐Model Nanoprobes for Multiscale Visualization of Macrophages in Rheumatoid Arthritis

Lan

Gao

et al. 2023

Adv Funct Materials

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation. Macrophages accelerate the pathological process of RA through the continuous cell accumulation and secretion of cytokines. Therefore, multiscale visualization of macrophages is of great significance for the early diagnosis of RA. In this work, folate receptor-targeted Cptnc-4F nanoprobes, named FA-CF-NPs, are developed for dual-model molecular imaging of macrophages in RA mouse models. FA-CF-NPs exhibit complementary imaging advantages with high fluorescence sensitivity and resolution in the second near-infrared window (NIR-II) and promising photoacoustic (PA) imaging contrast with deep tissue penetration. The high affinity of the folate ligand on the surface of FA-CF-NPs to macrophages with overexpressed folate receptors ensures the specific targeting function of the nanoprobes for imaging in vivo. FA-CF-NPs are employed to achieve NIR-II fluorescence imaging to accurately localize macrophages in the joint, obtaining a high signal-to-background ratio (SBR) of 15.5. Meanwhile, PA imaging is also performed to observe macrophage distribution in the longitudinal section of the whole joint. Moreover, macrophage infiltration is detected in the joint of RA mice with the absence of RA pathologies such as synovitis and cartilage loss. The results provide an opportunity for in vivo macrophage tracking and early diagnosis of RA.

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Section: Methodsmentioning

confidence: 99%

Folate Receptor‐Targeted NIR‐II Dual‐Model Nanoprobes for Multiscale Visualization of Macrophages in Rheumatoid Arthritis

Lan

Gao

et al. 2023

Adv Funct Materials

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“…Nanomaterials have the potential to be used to diagnose and treat various human diseases due to their unique ability to deliver therapeutic bioactive molecules to target sites [ 1 – 4 ]. Treatment strategies utilizing nanomaterials have demonstrated improved efficacy and safety when compared to conventional therapies [ 5 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Lopes¹,

Lopes²,

Pereira-Silva³

et al. 2023

Military Med Res

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A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nanomaterials with improved interfacial properties, superior cell targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production and application of exosomal membrane-coated nanomaterials. The structure, properties, and manner in which exosomes communicate with cells are first reviewed. This is followed by a discussion of the types of exosomes and their fabrication methods. We then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering, regenerative medicine, imaging, and the treatment of neurodegenerative diseases. Finally, we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

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“…As a chronic immune-mediated disease, rheumatoid arthritis (RA) is characterized by synovitis and destruction of articular cartilage [ 1 , 2 ]. Patients with RA are at higher risk for osteoporosis, cardiovascular disease and cancer, which results in significant social-economic problems [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Exosome inspired photo-triggered gelation hydrogel composite on modulating immune pathogenesis for treating rheumatoid arthritis

et al. 2023

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Although exosome therapy has been recognized as a promising strategy in the treatment of rheumatoid arthritis (RA), sustained modulation on RA specific pathogenesis and desirable protective effects for attenuating joint destruction still remain challenges. Here, silk fibroin hydrogel encapsulated with olfactory ecto-mesenchymal stem cell-derived exosomes (Exos@SFMA) was photo-crosslinked in situ to yield long-lasting therapeutic effect on modulating the immune microenvironment in RA. This in situ hydrogel system exhibited flexible mechanical properties and excellent biocompatibility for protecting tissue surfaces in joint. Moreover, the promising PD-L1 expression was identified on the exosomes, which potently suppressed Tfh cell polarization via inhibiting the PI3K/AKT pathway. Importantly, Exos@SFMA effectively relieved synovial inflammation and joint destruction by significantly reducing T follicular helper (Tfh) cell response and further suppressing the differentiation of germinal center (GC) B cells into plasma cells. Taken together, this exosome enhanced silk fibroin hydrogel provides an effective strategy for the treatment of RA and other autoimmune diseases.

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On-demand drug delivery of triptolide and celastrol by poly(lactic-co-glycolic acid) nanoparticle/triglycerol monostearate-18 hydrogel composite for rheumatoid arthritis treatment

Cited by 25 publications

References 55 publications

Folate Receptor‐Targeted NIR‐II Dual‐Model Nanoprobes for Multiscale Visualization of Macrophages in Rheumatoid Arthritis

Folate Receptor‐Targeted NIR‐II Dual‐Model Nanoprobes for Multiscale Visualization of Macrophages in Rheumatoid Arthritis

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Exosome inspired photo-triggered gelation hydrogel composite on modulating immune pathogenesis for treating rheumatoid arthritis

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