On-chip testing of the speed of magnetic nano- and micro-particles under a calibrated magnetic gradient

Benhal, Prateek; Broda, Andrew; Najafali, Daniel; Malik, Pulkit; Mohammed, Ahmed M.; Ramaswamy, Bharath; Depireux, Didier A.; Shimoji, Mika; Shukoor, Mohammed Ibrahim; Shapiro, Benjamin

doi:10.1016/j.jmmm.2018.10.148

Cited by 16 publications

(12 citation statements)

References 67 publications

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“…An experimental study of the wide range of magnetic particle speeds under magnetic gradients was conducted in Benhal et al. ( 2019 ). Targeting times of 1 h of applying magnetic sources have been reported in in-vivo studies (Muthana et al., 2015 ; Al-Jamal et al., 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery

et al. 2020

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“…All of the particles seem to have displayed consistent trends: i.e., larger MNPs move faster; the particles at higher concentrations make longer needle like aggregates and move faster,; both speed and chain increase with time while yielding a final speed proportional to the square of particle diameter. 148 In a similar study, Geczy et al have revealed that the resulting particles, through the encapsulation of MNPs, were monosized, highly spherical, and exhibited superparamagnetic properties. The particles’ size regime and their magnetic responses have demonstrated potentials for in-vivo intravenous applications of magnetic targeting with maximum magnetic response without blocking an organ’s capillaries.…”

Section: Tumor-on-a-chip Platforms For Np-transport and Testingmentioning

confidence: 93%

The Potential of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer Based on Body Magnetic Field and Organ-on-the-Chip

Alavijeh

Barati

et al. 2019

Adv Pharm Bull

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Cancer is an abnormal cell growth which tends to proliferate in an uncontrolled way and, in some cases, leads to metastasis. If cancer is left untreated, it can immediately cause death. The use of magnetic nanoparticles (MNPs) as a drug delivery system will enable drugs to target tissues and cell types precisely. This study describes usual strategies and consideration for the synthesis of MNPs and incorporates payload drug on MNPs. They have advantages such as visual targeting and delivering which will be discussed in this review. In addition, we considered body magnetic field to make drug delivery process more effective and safer by the application of MNPs and tumor-on-chip.

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“…Recent studies have illustrated how MNP behavior in response to magnetic fields can be deeply investigated using 3D microfluidic systems. For example, Benhala et al have studied the movement of MNPs in response to an applied magnetic field on an on-chip system, and observed that all particles with a diameter size between 10 and 100 μm displayed the same trend; faster movement when larger in size, and slower movement when smaller [ 85 ]. Moreover, in another work by Geczy et al, it has been reported that MNPs are highly spherical in shape and exhibit superparamagnetic properties [ 86 ] ( Table 3 ).…”

Section: 3d In Vitro Platforms For Investigating Exogenous Stimuli-responsive Drug Delivery Systemsmentioning

confidence: 99%

The Effective Combination between 3D Cancer Models and Stimuli-Responsive Nanoscale Drug Delivery Systems

Foglietta

Serpe

Canaparo

2021

Cells

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Stimuli-responsive drug-delivery systems (DDSs) have emerged as a potential tool for applications in healthcare, mainly in the treatment of cancer where versatile nanocarriers are co-triggered by endogenous and exogenous stimuli. Two-dimensional (2D) cell cultures are the most important in vitro model used to evaluate the anticancer activity of these stimuli-responsive DDSs due to their easy manipulation and versatility. However, some limitations suggest that these in vitro models poorly predict the outcome of in vivo studies. One of the main drawbacks of 2D cell cultures is their inadequate representation of the 3D environment’s physiological complexity, which sees cells interact with each other and the extracellular matrix (ECM) according to their specific cellular organization. In this regard, 3D cancer models are a promising approach that can overcome the main shortcomings of 2D cancer cell cultures, as these in vitro models possess many peculiarities by which they mimic in vivo tumors, including physiologically relevant cell–cell and cell–ECM interactions. This is, in our opinion, even more relevant when a stimuli-responsive DDS is being investigated. In this review, we therefore report and discuss endogenous and exogenous stimuli-responsive DDSs whose effectiveness has been tested using 3D cancer cell cultures.

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On-chip testing of the speed of magnetic nano- and micro-particles under a calibrated magnetic gradient

Cited by 16 publications

References 67 publications

Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery

Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery

The Potential of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer Based on Body Magnetic Field and Organ-on-the-Chip

The Effective Combination between 3D Cancer Models and Stimuli-Responsive Nanoscale Drug Delivery Systems

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