On-chip micro-electromagnets for magnetic-based bio-molecules separation

Ramadan, Qasem; Samper, Victor; Poenar, Daniel Puiu; Chen, Yu

doi:10.1016/j.jmmm.2004.04.100

Cited by 81 publications

(48 citation statements)

References 16 publications

(18 reference statements)

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“…These two factors are affecting the sorting efficiency in a contrasting manner. From Biot-Savart law, we know that the magnetic flux density, B at distance R from the stripline is given by (Ramadan et al 2004):…”

Section: Resultsmentioning

confidence: 99%

An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching

Kong

Sugiarto

et al. 2010

Microfluid Nanofluid

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The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering currentcarrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz.

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Section: Resultsmentioning

confidence: 99%

An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching

Kong

Sugiarto

et al. 2010

Microfluid Nanofluid

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“…In microfluidic systems, both permanent magnets and/or electromagnets can be used. Passive magnetic [68] elements or electromagnets [69,70] are usually assembled in the wall of the microchannels to trap the magnetic particles at the surface of the microchannel.…”

Section: Magnetic Trappingmentioning

confidence: 99%

Circulating tumor-cell detection and capture using microfluidic devices

Hajba

Guttman

2014

TrAC Trends in Analytical Chemistry

111

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A B S T R A C TCirculating tumor cells (CTCs) in the bloodstream are considered good indicators of the presence of a primary tumor or even metastases. CTC capture has great importance in early detection of cancer, especially in identifying novel therapeutic routes for cancer patients by finding personalized druggable targets for the pharmaceutical industry. Recent developments in microfluidics and nanotechnology improved the capabilities of CTC detection and capture, including purity, selectivity and throughput. This article covers the recent technological improvements in microfluidics-based CTC-capture methods utilizing the physical and biochemical properties of CTCs. We critically review the most promising hydrodynamic, dielectrophoretic and magnetic force-based microfluidic CTC-capture devices.

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“…Photolithographic techniques enable fabrication of almost any desired MET geometry; as a result the geometry of an MET can be tuned for a specific application. Ramadan et al [18,[21][22][23][24][25][26][27] and Lee et al [20,28] have demonstrated customized MP traps which emphasize the effects of different MET geometries. Simulations of magnetic fields produced by different MET geometries have magnetic field profiles attributed to the shape of the MET and magnetic coupling between conductors or loops.…”

Section: Geometrymentioning

confidence: 99%

“…The thickness of this layer also provides a method to alter the local magnetic field to direct the motion of magnetic particles. Several reports have shown that the magnetic field and gradient changes as a function of distance (z) above the METs [18,21,28,29]. For a meander MET, for example, the magnetic field generated away from an adjacent pair of wires was partially cancelled by the fields generated by the two wires immediately next to the pair.…”

Section: Effect Of Insulation Thickness and Current Magnitudementioning

confidence: 99%

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Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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Microelectromagnetic traps (METs) have been used for almost two decades to manipulate magnetic fields. Different trap geometries have been shown to produce distinct magnetic fields and field gradients. Initially, microelectromagnetic traps were used mainly to separate and concentrate magnetic material at small scales. Recently such traps have been implemented for unique applications, for example filterless bioseparations, inductive heat generation, and biological detection. In this review, we describe recent reports in which MET geometry, current density, or external fields have been used. Descriptions of recent applications in which METs have been used to develop sensors, manipulate DNA, or block ion current are also provided.

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On-chip micro-electromagnets for magnetic-based bio-molecules separation

Cited by 81 publications

References 16 publications

An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching

An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching

Circulating tumor-cell detection and capture using microfluidic devices

Applications of microelectromagnetic traps

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