On-chip generation and detection of electrochemiluminescence

Fiaccabrino, G. C.; Rooij, N. F. de; Koudelka‐Hep, M.

doi:10.1016/s0003-2670(97)00689-2

Cited by 51 publications

(65 citation statements)

References 13 publications

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“…The redox cycle of the species in IDUA was proposed by Bard et al in 1986(Bard et al, 1986. Further applications using IDUA (Fiaccabrino et al, 1998;Sheppard et al, 1996) and the search for the parameters of IDUA (Min & Baeumner, 2004) also have been reported. Additionally, there is another new way to increase the sensitivity up to 50 times by nanopores (Muller et al, 2007).…”

Section: Reviews and Motivationsmentioning

confidence: 99%

Amperometric Enzyme-based Biosensors for Lowering the Interferences

Nien¹,

Chen²,

Ho³

2010

Intelligent and Biosensors

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Section: Reviews and Motivationsmentioning

confidence: 99%

Amperometric Enzyme-based Biosensors for Lowering the Interferences

Nien¹,

Chen²,

Ho³

2010

Intelligent and Biosensors

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“…The electrochemiluminescence (ECL) reaction of ruthenium(II) tris(2,2 0 -bipyridyl) (Rubpy 3 2 ) has emerged as a very attractive tool because of the favorable properties of the Rubpy 3 2 complex [1,2]. A miniaturized and integrated sensor for ECL-based analytical assays was recently developed in our group.…”

Section: Introductionmentioning

confidence: 99%

“…It can be operated in batch or¯ow injection analysis mode. These systems were, respectively, used for the measurements of Rubpy 3 2 [3] and codeine [4]. The development of a reagentless and regenerable ECL based sensor implies the con®nement of Rubpy 3 2 complex at the surface of the sensor.…”

Section: Introductionmentioning

confidence: 99%

“…These systems were, respectively, used for the measurements of Rubpy 3 2 [3] and codeine [4]. The development of a reagentless and regenerable ECL based sensor implies the con®nement of Rubpy 3 2 complex at the surface of the sensor. Such a development is complex since it requires to select a matrix allowing the noncovalent retention of Rubpy 3 2 complex with a minimum leaching.…”

Section: Introductionmentioning

confidence: 99%

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Reagentless Sensor Integrating Electrodes, Photodetector, and Immobilized Co-Substrate for Electrochemiluminescence-Based Assays

Michel¹,

Wal

Fiaccabrino

et al. 1999

Electroanalysis

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A reagentless and regenerable electrochemiluminescence sensor has been developed by immobilizing the Rubpy 3 2 complex at the surface of a miniaturized sensor combining the electrode transducer and the photodetector on the same silicon chip. The immobilization was performed following a two-step procedure. The complex was ®rst incorporated in a sol-gel matrix which was ground to a powder. The microparticles thus obtained were then entrapped in a polyhydroxyethyl methacrylate membrane. The sensor was characterized by performing codeine assays with standard and pharmaceutical samples. The detection limit for codeine was 20 mM and the sensitivity of the sensor represented 20 % of the value obtained when the cosubstrate was supplied in solution. The self-containment working time was determined to be 7 days of reproducible measurements.

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“…[1][2][3][4][5][6][7] Redox cycles are generated between the two working electrodes; they are called the generator and the collector, and are placed close to each other. The generator current increases when a suitable potential is applied to the collector (a dual-mode), compared to a single-mode when the collector is electrically open.…”

mentioning

confidence: 99%

A Planar Gas Sensor Combined with Interdigitated Array Electrodes

et al. 1999

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Interdigitated array (IDA) electrodes are used for the determination of components contained in aqueous solutions with high sensitivity. [1][2][3][4][5][6][7] Redox cycles are generated between the two working electrodes; they are called the generator and the collector, and are placed close to each other. The generator current increases when a suitable potential is applied to the collector (a dual-mode), compared to a single-mode when the collector is electrically open. In a previous study 8 , IDA electrodes were applied to gas detection for the first time. The electrodes were fabricated on a gas-permeable membrane in order to obtain good response to the gases (NO x ) through improved conventional photolithography. It was confirmed that the IDA electrodes are useful in a gas-detection system, as well as in solution systems. Generally, the gap and width of the electrodes should be small in order to generate a large number of redox cycles. However, it was difficult to fabricate fine patterns on the gas-permeable membrane, because the membrane was flexible and its surface was not flat. On the other hand, it is already possible to fabricate fine IDA patterns on a hard and flat substrate and are already being marketed. However, if these electrodes fabricated on substrate are set in an electrolyte solution, they do not come into contact with the membrane. Therefore, it is said that the sensitivity and response speed are poor. Accordingly, we experimented with a new method of applying IDA electrodes to a gas-sensing system. We call it a planar IDA gas sensor. A piece of filter paper containing an electrolyte solution was put on IDA electrodes, which were fabricated on a glass substrate. This gas sensor was very easy to construct. A similar planar sensor had been reported for amperometric sensing of oxygen.9 It was developed as a low-cost and disposable sensor, and applied to glucose sensing. A planar sensor is expected to be more useful in complicated detection systems i.e. using IDA electrodes, which was confirmed after being used in a hydrogen-detection system. ExperimentalPropylene carbonate (PC) was purchased from Nacalai Tesque Inc. Tetraethylammonium perchlorate (TEAP) was prepared from tetraethylammonium bromide and perchloric acid, both of which were obtained from Wako Chemical Co. The precipitate of TEAP was purified by recrystallization from water and stored in an evacuated desiccator after baking at 100˚C. A PC solution containing 0.1 M TEAP was prepared as an electrolyte.A planar IDA gas sensor was prepared based on available IDA electrodes (No. 2047 from BAS). The width and gap of the electrodes were 10 µm and 5 µm, respectively. The valid length of the electrode was 2 mm, and the number of electrodes was 65 pairs. Keywords Interdigitated array electrodes, redox cycles, hydrogen gas sensor Fig. 1 Structures of planar gas sensors combined with IDA electrodes. The IDA electrodes used were fabricated on a glass substrate. The bandwidth of the generator and the collector were 10 µm, and the gap between them wa...

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On-chip generation and detection of electrochemiluminescence

Cited by 51 publications

References 13 publications

Amperometric Enzyme-based Biosensors for Lowering the Interferences

Amperometric Enzyme-based Biosensors for Lowering the Interferences

Reagentless Sensor Integrating Electrodes, Photodetector, and Immobilized Co-Substrate for Electrochemiluminescence-Based Assays

A Planar Gas Sensor Combined with Interdigitated Array Electrodes

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